Salmeterol xinafoate
- CAS No.
- 94749-08-3
- Chemical Name:
- Salmeterol xinafoate
- Synonyms
- 1-Hydroxy-2-naphthoate;Serevent;Salmeterol hydroxynaphthoate;Salmeterol Xinafoate (1609603);Arial;SN 408;Siduomi;GR 3343G;GR-33343G;Salmetedur
- CBNumber:
- CB2751968
- Molecular Formula:
- C36H45NO7
- Molecular Weight:
- 603.74
- MDL Number:
- MFCD00897708
- MOL File:
- 94749-08-3.mol
- MSDS File:
- SDS
Melting point | 137-138°C |
---|---|
storage temp. | 2-8°C |
solubility | H2O: slightly soluble |
form | solid |
color | white |
Merck | 14,8337 |
InChIKey | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
CAS DataBase Reference | 94749-08-3(CAS DataBase Reference) |
FDA UNII | 6EW8Q962A5 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P280-P271 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 22-24/25-36-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | QJ1970500 | |||||||||
HS Code | 2922504500 | |||||||||
NFPA 704 |
|
Salmeterol xinafoate price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S5068 | Salmeterol xinafoate ≥98% (HPLC), solid | 94749-08-3 | 10mg | $225 | 2024-03-01 | Buy |
Sigma-Aldrich | 1609603 | Salmeterol xinafoate United States Pharmacopeia (USP) Reference Standard | 94749-08-3 | 150mg | $1070 | 2024-03-01 | Buy |
TCI Chemical | A3190 | Salmeterol Xinafoate >98.0%(HPLC)(T) | 94749-08-3 | 250mg | $69 | 2024-03-01 | Buy |
TCI Chemical | A3190 | Salmeterol Xinafoate >98.0%(HPLC)(T) | 94749-08-3 | 1g | $188 | 2024-03-01 | Buy |
Cayman Chemical | 16009 | Salmeterol xinafoate ≥98% | 94749-08-3 | 10mg | $110 | 2024-03-01 | Buy |
Salmeterol xinafoate Chemical Properties,Uses,Production
Description
Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to be the first bronchodilator with significant anti-inflammatory activity and hence could complement prophylactic corticosteroid therapy.
Description
Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM. Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation. Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.
Chemical Properties
White to Off-White Solid
Originator
Glaxo (United Kingdom)
Uses
Bronchodilator; Beta2-adrenoceptor agonist
Uses
Smooth wheezing anti-inflammatory
Uses
A β2-Adrenergic agonist. Structural analog of Albuterol (A514500).
Uses
A ?-Adrenergic agonist. Structural analog of albuterol
Application
Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).
Definition
ChEBI: Salmeterol xinafoate is a naphthoic acid.
brand name
Serevent (GlaxoSmithKline).
Biochem/physiol Actions
β2-adrenoceptor agonist.
storage
Desiccate at RT
Salmeterol xinafoate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shandong Risen-Sun Pharmaceutical Co., Ltd | +86-15552509998 +86-15621883869 | liutf@jewim.com.cn | China | 251 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9357 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
View Lastest Price from Salmeterol xinafoate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Salmeterol xinafoate
94749-08-3
|
US $0.00 / KG | 1KG | 99% | 20 TONS | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2024-08-27 | Salmeterol xinafoate
94749-08-3
|
US $55.00-550.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2021-07-13 | Salmeterol xinafoate
94749-08-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Salmeterol xinafoate
94749-08-3
- US $0.00 / KG
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
- Salmeterol xinafoate
94749-08-3
- US $55.00-550.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
- Salmeterol xinafoate
94749-08-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd