살부타몰 C화학적 특성, 용도, 생산
물성
Albuterol Sulfate 또는 Albuterol은 Salbutamol으로도 알려져 있습니다. 스테로이드 호르몬 알부 테롤 설페이트는 보통 기관지 평활근에 대한 직접 효과에 대한 흡입 경로에 의해 제공됩니다. 이것은 일반적으로 정량 흡입기 (MDI), 분무기 또는 기타 독점적 인 전달 장치 (예 : Rotahaler 또는 Autohaler)를 통해 이루어집니다. 이러한 형태의 전달에서 salbutamol의 최대 효과는 투여 후 5 ~ 20 분 이내에 발생할 수 있지만 일부 완화는 즉시 나타납니다. 또한 정맥 주사로 투여 할 수 있습니다. 기관지 천식, 천식 기관지염, 폐기종, 환자의 기관지 경련 치료에 사용됩니다.
개요
Salbutamol 또는 albuterol은 천식 및 만성 폐색 성 폐 질환과 같은 상태에서 기관지 경련의 완화에 사용되는 단기 작용 β2-adrenergic receptor agonist입니다. 그것은 다른 상표 이름 중 Ventolin으로 판매됩니다.
Salbutamol은 1968 년에 판매 될 첫 번째 선택적 β2 수용체 작용제였습니다.이 제품은 Allent & Hanburys가 Ventolin이라는 브랜드로 처음 판매되었습니다. 이 약물은 즉각적인 성공을 거두어 그 이후로 천식 치료에 사용되었습니다.
용도
살부타몰(INN: salbutamol) 또는 알부테롤(USAN: albuterol)은 빠르게 반응하는 교감신경β2수용체작용제이며 천식과 만성 폐쇄성 폐질환과 같은 기관지 경련을 가라앉히는 데에 쓰인다.
개요
Albuterol is a β2-adrenergic sympathomimetic amine with pharmacological similarities to
terbutaline. It has almost no effect on β1-adrenoreceptors of the heart. It has expressed
broncholytic effects—prevention or relief of bronchi spasms, lowering respiratory tract
resistance, and increasing the vital capacity of the lungs.
화학적 성질
solid
용도
immune suppressant, antineoplastic, antiviral
정의
ChEBI: A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma
and chronic obstructive pulmonary disease (COPD).
Biological Functions
Levalbuterol is the R-(–)-isomer of albuterol and is available only in solution to be administered via nebulizer. Because it is the active isomer, the dose is fourfold less than that of albuterol. Pirbuterol is the pyridine isostere of albuterol. It has pharmacokinetics similar to albuterol but is half as potent at the β2-receptor. Pirbuterol is only available as an inhaler, whereas albuterol comes in tablet, syrup, solution, and aerosol formulations.
일반 설명
Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020. Salbutamol is classified under the β-agonist group of chemicals which are known to possess powerful pharmacological activities.
Clinical Use
Albuterol has the N-t-butyl and a salicyl alcohol phenyl ring, which gives it optimal β2-selectivity. It is resistant to COMT and slowly metabolized by MAO, giving it good oral bioavailability. Its onset by inhalation is within 5 minutes, with a duration of action between 4 and 8 hours. It currently is the drug of choice for relief of the acute bronchospasm of an asthmatic attack.
부작용
Adverse effects of pirbuterol are nervousness, tremor, and headache, which is less than the profile for albuterol, which adds nausea, vomiting, dizziness, hypertension, insomnia, tachycardia, and palpitations.
환경귀착
Tachycardia occurs as a reflex to the drop in mean arterial
pressure (MAP) or as a result of b-1 stimulus. b-Adrenergic
receptors in the locus coeruleus also regulate norepinephrineinduced
inhibitory effects, resulting in agitation, restlessness,
and hand tremor. Stimulation of nonpulmonary b2 receptors
may lead to an increase in heart rate, QTc interval prolongation,
nonspecific T-wave changes, skeletal muscle tremor, and slight
increases in blood glucose and nonesterified fatty acids. Hypokalemia
is more pronounced in patients receiving intravenous
albuterol. Hypotension is also known to occur mostly in overdose.
The buildup of cyclic AMP in the liver stimulates glycogenolysis
and an increase in serum glucose.
In skeletal muscle, this process results in increased lactate
production. Direct stimulus of sodium/potassium ATPase in
skeletal muscle produces a shift of potassium from the extracellular
space to the intracellular space. Relaxation of smooth
muscle produces a dilation of the vasculature supplying skeletal
muscle, which results in a drop in diastolic and MAP.Myocardial ischemia and infarction have been associated with
excessive tachycardia in elderly patients. The skin may be warm
and pink with evidence of diaphoresis.
살부타몰 준비 용품 및 원자재
원자재
준비 용품
