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갈륨 니트레이트

갈륨 니트레이트
갈륨 니트레이트 구조식 이미지
카스 번호:
13494-90-1
한글명:
갈륨 니트레이트
동의어(한글):
갈륨니트레이트;갈륨니트레이트
상품명:
GALLIUM NITRATE
동의어(영문):
ganite;nsc-15200;Ga(NO3)3nH2O;Wln: ga N-o3*3;GALLIUM NITRATE;galliumtrinitrate;Gallium(Ⅲ) nitrate;GALLIUM (III) NITRATE;Nitricacid,galliumsalt;GALLIUM NITRATE, 99.9%
CBNumber:
CB3209552
분자식:
GaN3O9
포뮬러 무게:
255.74
MOL 파일:
13494-90-1.mol

갈륨 니트레이트 속성

녹는점
110°C (dec.)
물리적 상태
Liquid
수용성
It is soluble in water.
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 8-36/37/38
안전지침서 17-26-36/37/39
유엔번호(UN No.) 1477
TSCA Yes
위험 등급 5.1
포장분류 III
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H272 화재를 강렬하게 함; 산화제 산화성 액체;산화성 고체 구분 2
구분 3
위험
경고
P210, P220, P221P280, P370+P378,P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
예방조치문구:
P221 가연성 물질과 혼합되지 않도록 조치하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

갈륨 니트레이트 C화학적 특성, 용도, 생산

개요

Gallium nitrate, initially developed as an anticancer agent, was introduced by Fujisawa as an orphan drug for the treatment of cancer-related hypercalcemia and bone metastases that do not respond to adequate hydration. The compound acts specifically on bone by inhibiting calcium resorption and also possibly by stimulating bone formation. Compared with calcitonin and etidronate, gallium nitrate is more potent and substantially longer acting. Other potential uses could be in the treatment of osteoporosis and Paget’s disease.

화학적 성질

white; crystal(s) powder(s) [MER06]

Originator

Memorial Sloan-Kettering Cancer Center (U.S.A.)

용도

Regulator (calcium).

상표명

Ganite (Genta).

일반 설명

White crystals.

공기와 물의 반응

Deliquescent. Water soluble.

반응 프로필

Oxidizing agents, such as GALLIUM NITRATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water; dissolution dilutes but does not nullify the oxidizing power of such materials. Organic compounds, in general, have some reducing power and can in principle react with compounds in this class. Actual reactivity varies greatly with the identity of the organic compound. Inorganic oxidizing agents can react violently with active metals, cyanides, esters, and thiocyanates.

화재위험

Flash point data for GALLIUM NITRATE are not available, but GALLIUM NITRATE is probably combustible.

Pharmaceutical Applications

In clinical trials, gallium nitrate has proved to be highly active as an antitumour agent especially against non-Hodgkin’s lymphoma and bladder cancer. The cytotoxic activity of gallium nitrate has been demonstrated as single agent and as part of combination therapy, for example, together with fluorouracil. Gallium nitrate shows a relatively low toxicity and does not produce myelosuppression, which is a significant advantage over other traditional anticancer agents. Furthermore, it does not appear to show any cross-resistance with conventional chemotherapeutic agents.
These studies have also shown that gallium nitrate is able to decrease serum calcium levels in patients with tumour-induced hypercalcaemia. Subsequently, several studies have been carried out comparing traditional bisphosphonate drugs with gallium nitrate in their ability to decrease the calcium levels that are elevated as a result of cancer. Based on the clinical efficacy, gallium nitrate injections (GaniteTM) was granted approval by the FDA for the treatment of cancer-associated hypercalcaemia. Gallium nitrate is also believed to inhibit the bone turnover and therefore to decrease osteolysis, the active reabsorption of bone material, in patients with bone metastasis secondary to other cancers.

갈륨 니트레이트 준비 용품 및 원자재

원자재

준비 용품


갈륨 니트레이트 공급 업체

글로벌( 51)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30163 84
Shanghai Sunway Pharmaceutical Technology Co., Ltd +86 (21) 51613915
+86 (21) 51613951 sales@sunwaypharm.com China 9894 57
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
HBCChem, Inc. +1-510-219-6317
+1-650-486-1361 sales@hbcchem.com United States 10661 60
Forsman Scientific ( Beijing ) Co., Ltd. +86-10-6464 6565
+86-10-6464 6568 info@forsman.com.cn;salesd@forsman.com.cn China 691 58
Ganzhou Jiayuan Advanced Materials Co.,Ltd. 0797-2196836
hong.qi@jiaton.com China 199 55
Shandong XiYa Chemical Industry Co., Ltd 4008-626-111
0539-6365991 3229735657@qq.com China 26779 60
Guangdong wengjiang Chemical Reagent Co., Ltd. 13680067450 0751-2886750
0751-2886756 QQ:3001264886 3001264886@qq.com China 14310 58

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