6-히드록시피리딘-2-카르복시산
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6-히드록시피리딘-2-카르복시산 속성
- 녹는점
- 270 °C (dec.) (lit.)
- 끓는 점
- 436.0±45.0 °C(Predicted)
- 밀도
- 1.451±0.06 g/cm3(Predicted)
- 저장 조건
- Inert atmosphere,Room Temperature
- 산도 계수 (pKa)
- 3.29±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 노란색에서 갈색으로
- BRN
- 115842
- InChIKey
- VRCWSYYXUCKEED-UHFFFAOYSA-N
- CAS 데이터베이스
- 19621-92-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
6-히드록시피리딘-2-카르복시산 C화학적 특성, 용도, 생산
화학적 성질
Light yellow Cryst용도
6-Hydroxypyridine-2-carboxylic acid may be used in the preparation of ruthenium(II) complex, [RuH(CO)(6-OH-py-2-COO)(PPh3)2].일반 설명
6-Hydroxypyridine-2-carboxylic acid (6HPA, 6-Hydroxypicolinic acid) is a picolinic acid derivative. It has been reported to exhibit enol-keto tautomerism. It is a chelating ligand exhibiting potential complexing ability (via N,O-chelation or N,O,O-chelation). Intramolecular proton transfer (IPT) in tautomeric forms of 6HPA has been investigated by density functional theory (DFT) calculations.Synthesis
6-Hydroxypicolinic acid is prepared by the reaction of 2-Bromo-6-hydroxypyridine and Carbon Dioxide. The specific synthesis steps are as follows:To a solution of 2-bromo-6-hydroxypyridine (0.76 g, 4.4 mmol,1.0 equiv.) in dry THF (20 mL) at 0 C was added a 2 M solution of -PrMgCl in THF (2.2 mL,4.4 mmol, 1.0 equiv.) during 5 min. The clear solution was stirred at that temperature for anadditional 5 min, and a 2.5 M solution of n-BuLi in hexanes (3.5 mL, 8.8 mmol, 2.0 equiv.) wasadded dropwise during 5min, while maintaining the temperature below 20 C. The resultingmixture was stirred at that temperature for 0.5 h, dry CO2 (0.20 g, 1.0 equiv.) was added to20 C. The resulting mixture was warmed to 20 C in 0.5 h and quenched with water (6 mL).After stirring the mixture below 20 C for 10 min, the phases were separated and the water phasewas extracted one additional time with ethyl acetate. The resulting suspension was allowed to reachroom temperature and fitered through a mbox0.5 1 cm pad of silica gel eluted with 10 mL of ethylacetate. The ?ltrate was concentrated and the residue was puri?ed by ash chromatography on silicagel (eluent: petroleum ether/ethyl acetate = 10:1) to afford product 3m as off-white solid, 0.56 g (yield: 93percent) , m.p.: 275–277 C. 1H-NMR (600 MHz, DMSO) 7.56 (dd, J = 8.9, 7.0 Hz, 1H), 6.97 (d, J = 6.8 Hz,1H), 6.65 (d, J = 9.0 Hz, 1H). 13C-NMR (151 MHz, DMSO) 163.28, 162.67, 140.51, 137.97, 123.88, 110.42.
6-히드록시피리딘-2-카르복시산 준비 용품 및 원자재
원자재
무수초산
과산화 수소
Methyl picolinate
아세트산(빙초산)
2H-PYRAN-2-ONE-6-CARBOXYLIC ACID
2-Bromo-6-hydroxypyridine
피콜린산
다이피콜린산
이산화탄소
준비 용품
6-히드록시피리딘-2-카르복시산 공급 업체
글로벌( 279)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
6-히드록시피리딘-2-카르복시산 관련 검색:
피콜리네이트 크롬(III) 2,5-피리딘디카르복시산 퀴놀린산 3-피리딘올 2,6-루티딘 피콜린산 시트라진산 6-히드록시피리딘-2-카르복시산
2-Bromo-5-nitropyridine
2-Chloro-3-hydroxypyridine
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Trolox
5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID
6-METHOXYPYRIDINE-2-CARBOXYLIC ACID
6-METHOXY-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER
2,6-DICHLORO-3-HYDROXYPYRIDINE-4-CARBOXYLIC ACID
2-Hydroxy-5-nitronicotinic acid
3-HYDROXYPICOLINIC ACID METHYL ESTER