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텔라프리비르

텔라프리비르
텔라프리비르 구조식 이미지
카스 번호:
402957-28-2
한글명:
텔라프리비르
동의어(한글):
텔라프리비르
상품명:
Telaprevir
동의어(영문):
CS-61;VX-950;MP-424;CS-1855;Incivek;LY-570310;Telaprevir;tellaprevir;Telaprevir-d4;Telaprevir, >=98%
CBNumber:
CB41519837
분자식:
C36H53N7O6
포뮬러 무게:
679.85
MOL 파일:
402957-28-2.mol

텔라프리비르 속성

밀도
1.25
산도 계수 (pKa)
11.84±0.20(Predicted)

안전

안전지침서 24/25
HS 번호 29339900

텔라프리비르 C화학적 특성, 용도, 생산

개요

The hepatitis C virus (HCV) protease inhibitor telaprevir (VX-950, MP- 424,LY-570310) was approved by the U.S. FDA in May 2011 for the treatment of genotype 1 chronic HCV infection in adult patients in combination with peginterferon alfa and ribavirin (PR). Telaprevir and boceprevir (vide supra) are the first two HCV protease inhibitors to be approved for treatment of HCV infection. Telaprevir is a HCV NS3-4A protease inhibitor that exerts its antiviral effect by blocking the release of nonstructural viral proteins from a polyprotein precursor. Telaprevir is a potent inhibitor of the protease (IC50=10 nM) and is active in cell culture (HCV 1b replicon assay, EC50=354 nM). Telaprevir was identified from efforts to truncate a decamer peptide inhibitor derived from the natural substrate NS5A-5B and was guided by structure-based design. The ketoamide group of telaprevir forms a covalent, reversible bond with the active site serine hydroxyl of the protease and compensates for the loss of affinity resulting from truncation of the peptide. Despite the presence of the reactive keto-amide group, telaprevir is >500-fold less potent against other serine proteases. Synthesis of the key octahydrocyclopenta[c]pyrrole-1-carboxylic acid fragment of telaprevir is achieved by a-deprotonation of Boc-protected 3-azabicyclo[3.3.0]nonane followed by reaction with CO2 and resolution of the racemic acid. Alternatively, deprotonation is carried out in the presence of a chiral amine to give the enantiomerically enriched acid.

화학적 성질

Telaprevir is White Solid

Originator

Eli Lilly (United States)

용도

A labelled peptidomimetic inhibitor of hepatitis C virus protease.

용도

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease.

용도

Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.

정의

ChEBI: An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used f r treatment of chronic hepatitis C virus genotype 1 infection.

상표명

Incivek

텔라프리비르 준비 용품 및 원자재

원자재

준비 용품


텔라프리비르 공급 업체

글로벌( 204)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3274 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58

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