Melanotan 1

Melanotan 1 구조식 이미지
카스 번호:
75921-69-6
상품명:
Melanotan 1
동의어(영문):
NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber:
CB4252333
분자식:
C78H111N21O19
포뮬러 무게:
1646.85
MOL 파일:
75921-69-6.mol

Melanotan 1 속성

밀도
1.46±0.1 g/cm3(Predicted)
RTECS 번호
OS1830200
저장 조건
−20°C
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
4.43±0.10(Predicted)
수용성
Soluble to 0.60 mg/ml in sterile water
시퀀스
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey
UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS 데이터베이스
75921-69-6(CAS DataBase Reference)

안전

WGK 독일 3

Melanotan 1 C화학적 특성, 용도, 생산

용도

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

일반 설명

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

부작용

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

Melanotan 1 준비 용품 및 원자재

원자재

준비 용품


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