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황산 스트렙토마이신

황산 스트렙토마이신
황산 스트렙토마이신 구조식 이미지
카스 번호:
3810-74-0
한글명:
황산 스트렙토마이신
동의어(한글):
황산스트렙토마이신;황산스트렙토마이신염;황산스트렙토마이신염(STREPTOMYCINSULFATESALT)
상품명:
Streptomycin sulfate
동의어(영문):
as-15;Gerox;Strycin;Strepto;Verstrep;strepcin;strepvet;vetstrep;Hortocyna;Strep-sol
CBNumber:
CB4290144
분자식:
C42H84N14O36S3
포뮬러 무게:
1457.38
MOL 파일:
3810-74-0.mol

황산 스트렙토마이신 속성

알파
-79~-88°(20℃/D)(c=1,H2O)(calculated on the dried basis)
밀도
1.2302 (rough estimate)
굴절률
-85 ° (C=1, H2O)
저장 조건
2-8°C
용해도
H2O: 0.1 g/mL, clear
물리적 상태
powder
색상
white to off-white
수소이온지수(pH)
pH (100g/l, 25℃) : 4.5~7.0
수용성
>=0.01 g/100 mL at 18 ºC
Merck
14,8826
BRN
3894995
안정성
Stable. Incompatible with strong oxidizing agents.
InChIKey
QTENRWWVYAAPBI-YZTFXSNBSA-N
EPA
D-Streptamine, O-2-deoxy-2-(methylamino)-. alpha.-L-glucopyranosyl-( 1.fwdarw.2)-O-5-deoxy-3-C- formyl-.alpha.-L-lyxofuranosyl-( 1.fwdarw.4)-N,N'-bis( aminoiminomethyl)-, sulfate (2:3) (salt)(3810-74-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38-63-42/43
안전지침서 26-36-36/37-45-22-60
WGK 독일 3
RTECS 번호 WK4990000
F 고인화성물질 3
TSCA Yes
HS 번호 29412000
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.

황산 스트렙토마이신 MSDS


O-2-Deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1->4)-N,N'-bis(aminoiminomethyl)-streptamine sulfate (2:3)

황산 스트렙토마이신 C화학적 특성, 용도, 생산

화학적 성질

White to off-white powder

용도

Antibiotic substance produced by aerobic fermentation. Antibacterial (tuberculostatic).

용도

Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis.

용도

Triacetine

상표명

Strycin (Bristol-Myers Squibb).

일반 설명

An antibacterial. White to light gray or pale buff powder with faint amine-like odor.

공기와 물의 반응

Hygroscopic. Water soluble.

반응 프로필

Streptomycin sulfate is a medicinal amino saccharide.

건강위험

SYMPTOMS: Symptoms of exposure to Streptomycin sulfate include skin rashes, eosinophilia, blood dyscrasias, stomatitis, anaphylactic shock, pruritus, scaling, and fever.

화재위험

Flash point data for Streptomycin sulfate are not available, however Streptomycin sulfate is probably combustible.

Clinical Use

Streptomycin sulfate is a white, odorless powder that is hygroscopicbut stable toward light and air. It is freely solublein water, forming solutions that are slightly acidic or nearlyneutral. It is very slightly soluble in alcohol and is insolublein most other organic solvents. Acid hydrolysis yields streptidineand streptobiosamine, the compound that is a combinationof L-streptose and N-methyl-L-glucosamine.
Streptomycin acts as a triacidic base through the effectof its two strongly basic guanidino groups and the moreweakly basic methylamino group. Aqueous solutions maybe stored at room temperature for 1 week without any lossof potency, but they are most stable if the pH is between 4.5and 7.0. The solutions decompose if sterilized by heating,so sterile solutions are prepared by adding sterile distilledwater to the sterile powder. The early salts of streptomycincontained impurities that were difficult to remove andcaused a histamine-like reaction. By forming a complexwith calcium chloride, it was possible to free the streptomycinfrom these impurities and to obtain a product thatwas generally well tolerated.
The organism that produces streptomycin, S. griseus, alsoproduces several other antibiotic compounds: hydroxystreptomycin,mannisidostreptomycin, and cycloheximide (q.v.).Of these, only cycloheximide has achieved importance as amedicinally useful substance. The term streptomycin A hasbeen used to refer to what is commonly called streptomycin,and mannisidostreptomycin has been called streptomycin B.Hydroxystreptomycin differs from streptomycin in having ahydroxyl group in place of one of the hydrogen atoms of thestreptose methyl group. Mannisidostreptomycin has a mannoseresidue attached in glycosidic linkage through the hydroxylgroup at C-4 of the N-methyl-L-glucosamine moiety.The work of Dyer et al. to establish the stereochemicalstructure of streptomycin has been completed, and confirmedwith the total synthesis of streptomycin and dihydrostreptomycinby Japanese scientists.

Safety Profile

Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Human systemic effects by intraperitoneal route: flaccid paralysis without anesthesia, motor activity changes and pulmonary changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also STREPTOMYCIN and SULFATES.

Purification Methods

The sulfate is recrystallised from H2O/EtOH, washed with a little EtOH, Et2O and dried in a vacuum. [UV and IR: Grove & Randall Antibiotics Monographs 2 163 1855, Heuser et al. J Am Chem Soc 75 4013 1953, Kuehl et al. J Am Chem Soc 68 1460 1946, Regna et al. J Biol Chem 165 631 1946.] During protein synthesis it inhibits initiation and causes misreading of mRNA [Zierhut et al. Eur J Biochem 98 577 1979, Chandra & Gray Methods Enzymol 184 70 1990]. [Beilstein 18/11 V 82.]

황산 스트렙토마이신 준비 용품 및 원자재

원자재

준비 용품


황산 스트렙토마이신 공급 업체

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0371-55170693
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Mainchem Co., Ltd.
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PI & PI BIOTECH INC.
020-81716320
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Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
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02783214688 bruce@xrdchem.cn CHINA 539 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2540 58

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