스테아릴 알코올
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스테아릴 알코올 속성
- 녹는점
- 56-59 °C (lit.)
- 끓는 점
- 210 °C15 mm Hg
- 밀도
- 0.812 g/mL at 25 °C (lit.)
- 증기 밀도
- 9.3 (vs air)
- 증기압
- <0.01 mm Hg ( 38 °C)
- 굴절률
- 1.4356 (estimate)
- 인화점
- 185°C
- 저장 조건
- 2-8°C
- 용해도
- 메탄올: 용해성10mg/mL, 투명, 무색
- 물리적 상태
- 플레이크
- 산도 계수 (pKa)
- 15.20±0.10(Predicted)
- Specific Gravity
- 0.812
- 색상
- 하얀색
- 냄새
- wh. unctuous flakes or gran., faint odor, bland taste
- 폭발한계
- ~8%
- 수용성
- 불용성
- Merck
- 14,8805
- BRN
- 1362907
- Dielectric constant
- 3.4(58℃)
- LogP
- 7.4
- CAS 데이터베이스
- 112-92-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 24/25 | ||
---|---|---|---|
유엔번호(UN No.) | UN 1986 | ||
WGK 독일 | - | ||
RTECS 번호 | RG2010000 | ||
자연 발화 온도 | 842 °F | ||
TSCA | Yes | ||
HS 번호 | 29051700 | ||
유해 물질 데이터 | 112-92-5(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: > 2000 mg/kg | ||
기존화학 물질 | KE-26419 |
스테아릴 알코올 C화학적 특성, 용도, 생산
화학적 성질
Stearyl alcohol, or 1-octadecanol, is an organic compound classified as a saturated fatty alcohol with the formula CH3(CH2)16CH2OH. It occurs as hard, white, waxy pieces, flakes, or granules, which have a slight characteristic odor and a bland taste. It is soluble in alcohol, acetone, and ether, but insoluble in water. Furthermore, it is combustible.용도
1-Octadecanol is used as a surfactant in cosmetics. It effectively moisturizes hands and face with pheohydrane, which is a complex derived from the microalgae Chlorella Vulgaris and hydrolyzed algin found in sea water. It is a saturated alcohol of high purity and can substitute for cetyl alcohol in pharmaceutical dispensing, in cosmetic creams, for emulsions, textile oils and finishes, as antifoam agent, lubricant, viscosity agent, builder, and chemical raw material.제조 방법
1-Octadecanol is prepared commercially via Ziegler aluminum alkyl hydrolysis or the catalytic, high-pressure hydrogenation of stearyl acid, followed by filtration and distillation. It may also be derived from natural fats and oils.주요 응용
1-Octadecanol is a long chain primary alcohol that is used in the production of emulsions, textile oils, antifoam agents, and lubricants. Other large scale applications include the manufacture of alkyl amines, tertiary amines, ethoxylates, halides/mercaptans, and polymerization stabilizers. It generally occurs as a mixture of solid alcohols whose primary constituent is 1-octadecanol. It occurs naturally in sperm whale oil and has been isolated from the hyperthermophilic bacterium Pyrococcus furiosus.1-Octadecanol has been used to model the plant epicuticular wax layer for an investigation by differential scanning calorimetry and Fourier transform infrared spectroscopy.
The use of 1-octadecanol to prepare microsphere formulations for such compounds as paclitaxel and indomethacin has been described.
생산 방법
Historically, stearyl alcohol was prepared from sperm whale oil but is now largely prepared synthetically by reduction of ethyl stearate with lithium aluminum hydride.정의
ChEBI: Octadecan-1-ol is a long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms. It has a role as a plant metabolite, a human metabolite and an algal metabolite. It is a long-chain primary fatty alcohol, a fatty alcohol 18:0 and a primary alcohol. It derives from a hydride of an octadecane.일반 설명
Mixed monolayers of 1-octadecanol and ethylene glycol monooctadecyl ether were studied to investigate their evaporation suppressing performance. The rate dependence of the collapse pressure for an octadecanolmonolayer using axisymmetric drop shape analysis has been investigated.건강위험
Mildly toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. A skin and eye irritant.화재위험
Flammable when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.Pharmaceutical Applications
1-Octadecanol is used in cosmetics and topical pharmaceutical creams and ointments as a stiffening agent. By increasing the viscosity of an emulsion, stearyl alcohol increases its stability. 1-Octadecanol also has some emollient and weak emulsifying properties, and is used to increase the water-holding capacity of ointments, e.g. petrolatum. In addition, 1-Octadecanol has been used in controlled-release tablets, suppositories, and microspheres.It has also been investigated for use as a transdermal penetration enhancer.Safety
Stearyl alcohol is generally considered to be an innocuous, nontoxic material. However, adverse reactions to stearyl alcohol present in topical preparations have been reported. These include contact urticaria and hypersensitivity reactions, which are possibly due to impurities contained in stearyl alcohol rather than stearyl alcohol itself.The probable lethal oral human dose is greater than 15 g/kg.
LD50 (rat, oral): 20 g/kg
Synthesis
1-Octadecanol is synthesized from Stearic acid, which may be obtained by saponification of Tallow, or hydrogenation of Cottonseed oil, from Castor oil or from other natural oils.저장
Stearyl alcohol is stable to acids and alkalis and does not usually become rancid. It should be stored in a well-closed container in a cool, dry place.Purification Methods
Crystallise octadecanol from MeOH, or dry Et2O and *C6H6, then fractionally distil it in vacuo. Also purify it by column chromatography. Free it from cetyl alcohol by zone refining. [Beilstein 1 IV 1888.]비 호환성
Incompatible with strong oxidizing agents and strong acids.참고 문헌
[1] P. SELVIN THOMAS. Electrical properties of natural rubber nanocomposites: effect of 1-octadecanol functionalization of carbon nanotubes[J]. Journal of Materials Science, 2011. DOI:10.1007/s10853-011-6174-4[2] DIANA N. H. TRAN. Molecular Interactions behind the Synergistic Effect in Mixed Monolayers of 1-Octadecanol and Ethylene Glycol Monooctadecyl Ether[J]. The Journal of Physical Chemistry B, 2013. DOI:10.1021/jp401027c
[3] Rowe, R.C., Sheskey, P.J., & Quinn, M. (1994). Handbook of Pharmaceutical Excipients.
스테아릴 알코올 준비 용품 및 원자재
원자재
준비 용품
STEARYL TARTRATE
티오디프로피온산 디스테아릴
데실 알코올
염화 디메틸디옥타데실암모늄
사이클릭 네오펜탄테트라일비스(옥타데실 포스파이트)
옥타데센(1-)
N,N-디메틸-1-옥타데칸아민
스테아트라이모늄클로라이드
1-브로모옥타데칸
demulsifier KN-1
Antifoaming agent DEF
스테아릴모노글리세리딜구연산염
스테아릴-β-(3,5-디-t-부틸-4-하이드록시페닐)프로피오네이트
P-TOLUENESULFONIC ACID N-OCTADECYL ESTER
바틸알코올
Cation hydroxy silicone oil emulsion
softener DOD
Fatty alcohol polyoxyethylene ether
스테아릴 알코올 공급 업체
글로벌( 533)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 |
overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 874 | 58 |
Shandong Dexiang International Trade Co., Ltd | +8615662695772 |
2476434775@qq.com | China | 998 | 58 |
Wuhan Boyuan Import & Export Co., LTD | +8615175982296 |
Mike@whby-chem.com | China | 33 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Nanjing Deda New Material Technology Co., Ltd | +8613223293093 |
bella@njdeda.com | China | 80 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 253 | 58 |