코르티존
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코르티존 속성
- 녹는점
- 223-228 °C (dec.)(lit.)
- 알파
- D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
- 끓는 점
- 412.46°C (rough estimate)
- 밀도
- 1.28±0.1 g/cm3 (20 ºC 760 Torr)
- 굴절률
- 210 ° (C=1, EtOH)
- 인화점
- 9℃
- 저장 조건
- -20°C Freezer
- 용해도
- Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Ethanol (Slightly, Heated)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 12.37±0.60(Predicted)
- 색상
- 흰색에서 옅은 베이지까지
- 수용성
- 229.9mg/L(25℃)
- Merck
- 2539
- LogP
- 1.470
- CAS 데이터베이스
- 53-06-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,T,Xn | ||
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위험 카페고리 넘버 | 11-23/24/25-39/23/24/25-63 | ||
안전지침서 | 22-24/25-45-36/37-16-7 | ||
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK 독일 | 3 | ||
RTECS 번호 | GM9020000 | ||
F 고인화성물질 | 18 | ||
HS 번호 | 2937210000 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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코르티존 C화학적 특성, 용도, 생산
화학적 성질
Off-White Crystalline Powder용도
Cortisone is used for inflammatory processes, allergies, and adrenal insufficiency.정의
ChEBI: A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.일반 설명
Cortisone is a corticosteroid produced in the adrenal glands. Cortisone is administered for short term pain relief and to reduce swelling from inflammation. This Certified Spiking Solution? is applicable in LC-MS/MS applications for endocrinology, clinical chemistry and neonatal screening.위험도
Damaging side effects, e.g., sodium retention from ingestion.Pharmacokinetics
Following oral administration, cortisone acetate and hydrocortisone acetate are completely and rapidly deacetylated by first-pass metabolism. Much of the oral cortisone, however, is inactivated by oxidative metabolism before it can be converted to hydrocortisone in the liver. The pharmacokinetics for hydrocortisone acetate is indistinguishable from that of orally administered hydrocortisone. Oral hydrocortisone is completely absorbed, with a bioavailability of greater than 95% and a half-life of 1 to 2 hours (23).Clinical Use
Cortisone is administered orally or by intramuscular (IM) injection as its 21-acetate (cortisone acetate).Cortisone acetate or hydrocortisone usually is the corticosteroid of choice for replacement therapy in patients with adrenocortical insufficiency, because these drugs have both glucocorticoid and mineralocorticoid properties.신진 대사
The metabolism of hydrocortisone has been previously described. Cortisone acetate is slowly absorbed from IM injection sites over a period of 24 to 48 hours and is reserved for patients who are unable to take the drug orally. The acetate ester derivative demonstrates increased stability and has a longer duration of action when administered by IM injection. Thus, smaller doses can be used. Similarly, hydrocortisone may be dispensed as its 21-acetate (hydrocortisone acetate), which is superior to cortisone acetate when injected intra-articularly.Purification Methods
Crystallise cortisone from 95% EtOH or acetone. The UV has 14,000 M-1cm -1 at 237nm (EtOH). [Beilstein 8 IV 3480, Hems J Pharm Pharmacol 5 409 1953, Beilstein 8 IV 3480.]코르티존 준비 용품 및 원자재
원자재
준비 용품
코르티존 공급 업체
글로벌( 226)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
코르티존 관련 검색:
히드로코르티손 프레드니솔론-21-아세트산 프레드니손 라이히슈타인 물질 S 히드로코르티손 아세트산 코르티손-21-아세트산
4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE
Hydrocortisone-17-butyrate
Benazepril
Prednisone 21-acetate
5-Bromo-2,3-difluorophenol
11-DEHYDROCORTICOSTERONE
11-KETOPROGESTERONE
CORTISONE 21-HEMISUCCINATE
4-Pregnene-17,21-diol-3,11,20-trione 21-sulphate,sodium salt
CORTISONE GLUCURONIDE,CORTISONE-21BETA-GLUCURONIDE
4-PREGNEN-17,21-DIOL-3,11,20-TRIONE SULPHATE, TRIETHYL AMMONIUM SALT
CORTISONE MESYLATE