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Cephaloridine

Cephaloridine 구조식 이미지
카스 번호:
50-59-9
상품명:
Cephaloridine
동의어(영문):
Sefacin;Ceporin;Ceporan;Ceflorin;Keflodin;Keflordin;Cephaloridine;Cephaloridine II;Cephaloridine USP/EP/BP;CEFALORIDINE (ALPHA FORM) USP/EP/BP
CBNumber:
CB4875354
분자식:
C19H17N3O4S2
포뮬러 무게:
415.48
MOL 파일:
50-59-9.mol

Cephaloridine 속성

녹는점
184°C
알파
D +47.7° (c = 1.25 in water)
밀도
1.3230 (rough estimate)
굴절률
1.6390 (estimate)
저장 조건
2-8°C
산도 계수 (pKa)
3.2(at 25℃)
수용성
>20g/L(21 ºC)

안전

위험품 표기 Xn
위험 카페고리 넘버 42/43
안전지침서 22-36/37-45
유해 물질 데이터 50-59-9(Hazardous Substances Data)
독성 LD50 mice, rats (g/kg): >15, 2.5-4 orally; in monkeys (g/kg): >0.2 i.m. (Atkinson)

Cephaloridine C화학적 특성, 용도, 생산

Originator

Ceporin,Glaxo,UK,1964

용도

Antibacterial agent.

정의

ChEBI: A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.

Manufacturing Process

7-Aminocephalosporanic acid (5.00 g) which passed through a 100-mesh sieve was suspended in boiling ethyl acetate (200 ml), and 2-thienylacetyl chloride (Cagniant, Bull. Soc. Chim. France, 1949, 847) (4.42 g, 1.5 equiv.) was added in ethyl acetate (20 ml). The mixture was boiled under reflux for 40 minutes, cooled, and filtered. Aniline (5.03 ml) was added, and after 1 hour the mixture was extracted with 3% sodium hydrogen carbonate solution (1 x 150 ml, 2 x 100 ml, 1 x 50 ml) and the alkaline extracts washed with ethyl acetate (3 x 100 ml). The aqueous solution was acidified to pH 1.2, and extracted with ethyl acetate (2 x 150 ml). The ethyl acetate extract was washed with water (4 x 40 ml), dried (MgSO4), and concentrated in vacuo to low volume. The crude 7-2'-thienylacetamidocephalosporanic acid (2.5 g) which separated was collected by filtration. Evaporation of the filtrate gave a further 2.68 g (71%) of the product, which was purified by crystallization from ethyl acetate, then aqueous acetone, MP 150°C to 157°C (decomp.).
7-2'-Thienylacetamidocephalosporanic acid (7.0 g) was suspended in water (60 ml) and stirred with pyridine (7 ml) until the acid dissolved. The resulting solution (pH 5.9) was kept at 35°C for 3 days, then filtered and extracted with methylene chloride (4 x 60 ml). The methylene chloride extract was back-extracted with a little water and the total aqueous solutions were then percolated through a column of Dowex 1 x 8 resin, (100 to 200 mesh, 150 g) in the acetate form at pH 4.3. The column was washed with water until the optical rotation of the eluate fell to zero and the eluate (500 ml) was freeze-dried. The residual white solid was dissolved in the minimum volume of methanol and after a few minutes the pyridine derivative crystallized; this is the cephaloridine product.

상표명

Kefloridin (Lilly); Loridine (Lilly);Cepalorin;Faredina;Latorex;Lauridin.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Cefaloridine, a semi-synthetic cephalosporin antibiotic, was introduced into medicine in 1964 for the treatment of bacterial infections. It is considered to be the most toxic of the cephalosporins, and for this reason is now seldom used. Nevertheless, it still remains available in certain countries and the World Health Organization is not aware of restrictive actions taken elsewhere.

위험도

Moderately to very toxic.

Cephaloridine 준비 용품 및 원자재

원자재

준비 용품


Cephaloridine 공급 업체

글로벌( 19)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
BOC Sciences
16314854226
inquiry@bocsci.com United States 19674 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 info@dycnchem.com CHINA 52932 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 waley188@sohu.com China 12341 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
+86 21 50676805 China 9914 58
Anhui kuer Bioengineering Co., Ltd 13810511747 0551-65171243-
kuer@kuerhuaxue.com China 2921 55
Aikon International Limited 13611564524 025-58851090-
(6)02557626880 lwan@aikonchem.com China 13907 58

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