페니실아민
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페니실아민 속성
- 녹는점
- 210 °C (dec.)(lit.)
- 끓는 점
- 251.8±35.0 °C(Predicted)
- 알파
- -65 º (c=5, 1M NaOH, on dry)
- 밀도
- 1.113 (estimate)
- 굴절률
- -63 ° (C=1, 1mol/L NaOH)
- 저장 조건
- 2-8°C
- 용해도
- H2O: 가용성100mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa 7.83±0.01(H2O,t =37±0.05,I=0.15)(Approximate)
- 색상
- 흰색에서 거의 흰색
- optical activity
- -6325 (pyridine), L-form: +6325 (1 mol dm-3 NaOH)
- 수용성
- 11.1g/100mL(20℃)
- Merck
- 14,7088
- BRN
- 1722375
- BCS Class
- 3
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- VVNCNSJFMMFHPL-VKHMYHEASA-N
- CAS 데이터베이스
- 52-67-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
위험품 표기 | Xi,T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-40-20/21/22 | ||
안전지침서 | 26-36-24/25-22 | ||
WGK 독일 | 2 | ||
RTECS 번호 | YV9425000 | ||
위험 참고 사항 | Toxic | ||
HS 번호 | 29309016 | ||
유해 물질 데이터 | 52-67-5(Hazardous Substances Data) | ||
독성 | LD50 in rats (mg/kg): >10000 orally, >660 i.p. (Jaffe) | ||
기존화학 물질 | KE-23114 |
페니실아민 C화학적 특성, 용도, 생산
개요
Penicillamine is an orally bioavailable copper chelator and penicillin degradation product. It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels. Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene. Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME and 7-nitroindazole . Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.화학적 성질
White to off-white crystalline powder용도
As a Penicillin metabolite, D-(-)-Penicillamin can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.정의
ChEBI: An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.일반 설명
D-Penicillamine contains a β-lactam chemical structure.Safety Profile
Poison by intraperitoneal route. Moderately toxic by subcutaneous and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by ingestion: agranulocytosis, dermatitis, fever, hemorrhage, increased body temperature, dermatitis, leukopenia, proteinuria, thrombocytopenia. Human teratogenic effects by an unspecified route: developmental abnormalities of the craniofacial areas, skin, and skin appendages, and body wall. Experimental reproductive effects. Questionable human carcinogen producing leukemia. Mutation data reported. Used in the treatment of rheumatoid arthritis, metal poisonings, and cystinuria. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.Synthesis
d-penicillamine can be synthesized in a multistep process that begins with heating isobutyraldehyde, pyridine, sulfur, and ammonia in benzene to form 5,5-dimethyl-2- isopropyl-?3-thiazoline. Treatment with hydrogen cyanide gives 4-cyano-5,5-dimethyl- 2-isopropylthiazolidine, which on acid hydrolysis gives d,l-penicillamine hydrochloride. Resolution is accomplished by conversion of the racemate to d,l-3-formyl- 2,2,5,5-tetramethylthiazolidine-4-carboxylic acid by treatment first with acetone, then with acetic formic anhydride. The enantiomers are separated in the usual manner, using, for example, l-lysine or d-(?)- threo-1-(4-nitrophenyl)-2-aminopropane-1,3- diol. Acidification liberates d-3-formyl- 2,2,5,5-tetramethylthiazolidine-4-carboxylic acid, which is hydrolyzed with hydrochloric acid to yield d-penicillamine hydrochloride. Neutralization with ethanolic triethylamine affords d-penicillamine.Purification Methods
The melting point of D-(-)-penicillamine depends on the rate of heating (m 202-206o is obtained by starting at 195o and heating at 2o/minute). It is soluble in H2O and alcohols but insoluble in Et2O, CHCl3, CCl4 and hydrocarbon solvents. Purify it by dissolving it in MeOH and adding Et2O slowly. Dry it in vacuo and store it under N2. [Weight et al. Angew Chem, Int Ed (English) 14 330 1975, Cornforth in The Chemistry of Penicillin (Clarke, Johnson and Robinson eds) Princeton Univ Press, 455 1949, Review: Chain et al. Antibiotics (Oxford University Press) 2 1949, Polymorphism: Vidler J Pharm Pharmacol 28 663 1976]. The D-S-benzyl derivative has m 197-198o (from H2O), [] D 17 -20o (c 1, N NaOH), -70o (N HCl). [Beilstein 4 IV 3228.]페니실아민 준비 용품 및 원자재
원자재
페니실린 G 칼륨
페닐히드라진
수산화나트륨
염화수은(II)
황화 수소
4-Thiazolidinecarboxylic acid, 5,5-dimethyl-2-[2-oxo-1-[(phenylacetyl)amino]-2-[(2-phenylethyl)amino]ethyl]-, [2R-[2α(R*),4β]]- (9CI)
4-Thiazolidinecarboxylic acid, 5,5-dimethyl-2-[[(2-phenylacetyl)amino]methyl]-, (2R,4S)-
2-아미노티오페놀
1,4-벤젠다이아민
준비 용품
페니실아민 공급 업체
글로벌( 353)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
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Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
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Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
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career henan chemical co | +86-0371-86658258 +8613203830695 |
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.GZ HONESTCHEM CO.,LTD | +86-15013270415 |
honestchemical@foxmail.com | China | 246 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7621 | 58 |
페니실아민 관련 검색:
페니실린 G 칼륨 메틸아크릴로일옥시에틸 포프폴린 콜린 페니실아민 암피실린 나트륨 암피실린 무수산염 6-아미노페니실란 산 페니실린 V 칼륨 D-디페니실아민 디설파이드 아목시실린
PENITREM A
Nafcillin sodium salt monohydrate
Mezlocillin
Dicloxacillin sodium
OXACILLIN SODIUM
7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID
Cloxacillin-13C4 SodiuM Salt
Penicillin G
(S)-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID