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아목시실린

아목시실린
아목시실린 구조식 이미지
카스 번호:
26787-78-0
한글명:
아목시실린
동의어(한글):
아목시실린;아목시실린(AMOXICILLIN)
상품명:
Amoxicillin
동의어(영문):
ampc;sumox;amoxi;Amopen;amolin;amoxil;Optium;Trimox;Utimox;piramox
CBNumber:
CB3690305
분자식:
C16H19N3O5S
포뮬러 무게:
365.4
MOL 파일:
26787-78-0.mol

아목시실린 속성

녹는점
140 °C
끓는 점
743.2±60.0 °C(Predicted)
밀도
1.54±0.1 g/cm3(Predicted)
저장 조건
2-8°C
용해도
Do you have solubility information on this product that you would like to share
산도 계수 (pKa)
pKa 2.4 (Uncertain)
물리적 상태
solid
Merck
13,582
BRN
7507120
안정성
Stable. Incompatible with strong oxidizing agents.
InChIKey
LSQZJLSUYDQPKJ-UWFZAAFLSA-N
CAS 데이터베이스
26787-78-0(CAS DataBase Reference)
EPA
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- (26787-78-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 42/43
안전지침서 22-36/37
WGK 독일 2
RTECS 번호 XH8300000
HS 번호 29411000
유해 물질 데이터 26787-78-0(Hazardous Substances Data)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P342+P311 호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.

아목시실린 MSDS


Amoxicillin

아목시실린 C화학적 특성, 용도, 생산

화학적 성질

solid

용도

Antibacterial;Bacterial transpeptidase inhibitor

정의

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.

상표명

Amoxil (GlaxoSmithKline); Dispermox (Ranbaxy); Larotid (GlaxoSmithKline); Trimox (Apothecon) [Name previously used: Amoxycillin.].

Antimicrobial activity

The antibacterial spectrum is identical to that of ampicillin and there are few differences in antibacterial activity . Like ampicillin, amoxicillin is unstable to most β-lactamases. It has useful activity against Helicobacter pylori (<1% resistance), and is included in most combination regimens for the treatment of H. pylori infections.

원료

There is complete cross-resistance with ampicillin. Its action against many β-lactamase-producing strains can be restored by co-administration with β-lactamase inhibitors.

색상 색인 번호

Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.

Pharmacokinetics

Oral absorption: 75–90%
Cmax 500 mg oral: 5.5–7.6 mg/L after 1–2 h
500 mg intramuscular: c. 14 mg/L after 1–2 h
Plasma half-life: 1 h
Volume of distribution: 0.3 L/kg
Plasma protein binding: 17–20%
Absorption and distribution
Oral absorption produces over twice the peak concentration achieved by comparable doses of ampicillin, allowing less frequent dosing intervals. Absorption is unaffected by food. It is well-distributed in multiple body fluids, including pleural, peritoneal and middle ear fluid. It does not penetrate well into the CSF.
Metabolism and excretion
Some 10–25% is converted to the penicilloic acid. Between 50% and 70% of unchanged drug is recovered in the urine in the first 6 h after a dose of 250 mg. Plasma levels are elevated and prolonged by the administration of probenecid.

Clinical Use

Amoxicillin, 6-[D-(-)-α-amino-p- hydroxyphenylacetamido]penicillanic acid (Amoxil, Larotid, Polymox), a semisyntheticpenicillin introduced in 1974, is simply the p-hydroxyanalog of ampicillin, prepared by acylation of 6-APA with phydroxyphenylglycine.Its antibacterial spectrum is nearly identical with that ofampicillin, and like ampicillin, it is resistant to acid, susceptibleto alkaline and β-lactamase hydrolysis, andweakly protein bound. Early clinical reports indicated thatorally administered amoxicillin possesses significantadvantages over ampicillin, including more complete GIabsorption to give higher plasma and urine levels, lessdiarrhea, and little or no effect of food on absorption.50Thus, amoxicillin has largely replaced ampicillin for thetreatment of certain systemic and urinary tract infectionsfor which oral administration is desirable. Amoxicillin isreportedly less effective than ampicillin in the treatment ofbacillary dysentery, presumably because of its greater GIabsorption. Considerable evidence suggests that oral absorptionof α-aminobenzyl–substituted penicillins (e.g.,ampicillin and amoxicillin) and cephalosporins is, at leastin part, carrier mediated, thus explaining their generallysuperior oral activity.Amoxicillin is a fine, white to off-white, crystallinepowder that is sparingly soluble in water. It is available invarious oral dosage forms. Aqueous suspensions are stablefor 1 week at room temperature.

Clinical Use

Isolates should be tested for susceptibility before use, especially for serious infections.
Ear, nose and throat infections other than pharyngitis, which may mask glandular fever
Tracheobronchitis, bronchitis, pneumonia
Genitourinary tract infections, including gonorrhea
Infections of skin and soft tissues due to streptococci and susceptible staphylococci
Helicobacter pylori infection (in combination with a proton pump inhibitor and at least one other antimicrobial agent such as clarithromycin)
Prophylaxis of endocarditis in patients undergoing dental treatment and other procedures

부작용

Amoxicillin is generally well tolerated, side effects being those common to penicillins, but including non-allergic rashes in patients with glandular fever. As the drug is well absorbed, diarrhea is generally infrequent and rarely sufficiently severe to require withdrawal of treatment.

Veterinary Drugs and Treatments

Amoxicillin/potassium clavulanate tablets and oral suspension products are approved for use in dogs and cats for the treatment of urinary tract, skin and soft tissue infections caused by susceptible organisms. It is also indicated for canine periodontal disease due to susceptible strains of bacteria.

Veterinary Drugs and Treatments

The aminopenicillins have been used for a wide range of infections in various species. FDA-approved indications/species, as well as non-approved uses, are listed in the Dosages section below.

아목시실린 준비 용품 및 원자재

원자재

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