Maprotiline
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Maprotiline 속성
- 녹는점
- 92-94°
- 끓는 점
- 410.26°C (rough estimate)
- 밀도
- 0.9801 (rough estimate)
- 굴절률
- 1.4900 (estimate)
- 산도 계수 (pKa)
- pKa 10.5±0.2(H2O t=25.0) (Uncertain)
- 수용성
- 833.4ug/L(22.5ºC)
- CAS 데이터베이스
- 10262-69-8(CAS DataBase Reference)
안전
| 유엔번호(UN No.) | 3249 | ||
|---|---|---|---|
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| 독성 | LD50 oral in rat: 760mg/kg |
Maprotiline C화학적 특성, 용도, 생산
용도
Maprotiline disrupts neuronal reuptake of monoamines in the CNS and possesses moderate tranquilizing and cholinergic activity. It improves mood significantly and relieves feelings of fear. Maprotiline is used in various forms of depression accompanied by a feeling of fear and irritability.Mechanism of action
Maprotiline is slowly but completely absorbed from the GI tract, and like the other TCAs, it is metabolized by the polymorphic CYP2D6 and CYP2C19 isoforms in the liver, primarily to pharmacologically active N-desmethylmaprotiline and to maprotiline-N-oxide.Maprotiline is distributed into breast milk at concentrations similar to those found at steady state in maternal blood. The elimination half-life of maprotiline averages 43 hours (60–90 hours for its N-desmethyl metabolite).Maprotiline shares the toxic potentials of the TCAs, and the usual precautions of TCA administration should be observed.Clinical Use
Maprotiline is a secondary amine dibenzobicyclooctadiene (a tetracyclic antidepressant) that differs structurally from the TCAs by having an ethylene bridge in its central ring, resulting in a rigid bicyclomolecular skeleton .Maprotiline exhibits the highest affinity and selectivity for the NE transporter. Its antidepressant mechanism of action is similar to that of desipramine, with an onset of action of up to 2 to 3 weeks.
부작용
Although most of the TCAs have been reported to induce seizures, it is generally recognized that maprotiline may be associated with a higher incidence of dose-dependent seizures compared with the other secondary TCAs. Maprotiline has been reported to produce sedation in depressed patients and to reduce aggressive behavior in animals. Maprotiline also shares the anticholinergic and cardiovascular effects of the secondary TCAs and may cause electrocardiographic changes, tachycardia, and postural hypotension.Maprotiline 준비 용품 및 원자재
원자재
안트라센
메틸아민
3-ANTHRACEN-9-YL-PROPIONIC ACID
에틸렌
수소화 리튬알미늄
염화 티오닐
N-Methyl-9,10-ethanoanthracene-9(10H)-propionamide
9,10-Ethanoanthracene-9(10H)-propionic acid
안트론
준비 용품
Maprotiline 공급 업체
글로벌( 46)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9116 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 |
peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32360 | 55 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 17825480238 |
3008233717@qq.com | China | 9844 | 12 |