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L-페니실아민

L-페니실아민 구조식 이미지

카스 번호:: 1113-41-3

한글명:: L-페니실아민

동의어(한글):: L-페니실아민

상품명:: L-Penicillamine

동의어(영문):: l-valin;H-PEN-OH;3-MERCAPTO-L-VALINE;3,3-DIMETHYL-L-CYSTEINE;L-Pen-OH;L-(+)-B2;NSC 241261;3-Mercapto-;3-THIOL-VALINE;-Penicillamine

CBNumber:: CB6302922

분자식:: C5H11NO2S

포뮬러 무게:: 149.21

MOL 파일:: 1113-41-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 215

L-페니실아민 속성

녹는점: 206 °C (dec.)(lit.)

끓는 점: 251.8±35.0 °C(Predicted)

알파: 61.9 º (C=0.5 IN 1 M NAOH)

밀도: 1.113 (estimate)

굴절률: 63 ° (C=1, 1mol/L NaOH)

저장 조건: Keep in dark place,Inert atmosphere,Room temperature

용해도: 수성 염기(소량으로 용해), DMSO(약간 용해됨, 가열), 물(약간 용해됨)

산도 계수 (pKa): 2.13±0.12(Predicted)

물리적 상태: 결정성 분말

색상: 흰색에서 거의 흰색

optical activity: [α]24/D +61.9°, c = 0.5 in 1 M NaOH

Merck: 14,7088

BRN: 1722374

안정성: 흡습성

InChIKey: VVNCNSJFMMFHPL-GSVOUGTGSA-N

CAS 데이터베이스: 1113-41-3(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi,Xn
위험 카페고리 넘버	36/37/38-40-20/21/22
안전지침서	26-36-22-24/25
WGK 독일	2
RTECS 번호	YV9445500
HS 번호	29309090
독성	LD50 i.p. in rats: 350 mg/kg (Jaffe)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P305+P351+P338

눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	1
2		0

L-페니실아민 C화학적 특성, 용도, 생산

화학적 성질

white to almost white crystalline powder

용도

As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Indications

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.

정의

ChEBI: The L-enantiomer of penicillamine.

Mechanism of action

The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.

Pharmacology

Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.

Safety Profile

A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.

Purification Methods

Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-페니실아민 준비 용품 및 원자재

원자재

준비 용품

H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH

L-페니실아민 공급 업체

글로벌( 215)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091 +86-18616643091	info@rochipharma.com	China	246	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58

L-페니실아민 관련 검색:

L-(+)-발린 티오글리콜산 2-에틸헥실 머캡토아세트산 6-머캡토퓨린 3-메르캅토프로피온산 칼슘 티오글리콜산염 티오글리콜산 나트륨 DL-페니실아민 2-머캅토에탄올 페니실아민 멜라티온 L-페니실아민 (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL POTASSIUM THIOGLYCOLATE 3-mercapto-L-valine hydrochloride 3-(4-acetylphenyl)-2-aminopropanoic acid hydrochloride 3-METHOXY-L-PHENYLALANINE (S)-2-AMino-3-(3-iodophenyl)propanoic acid