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L-(+)-발린

L-(+)-발린
L-(+)-발린 구조식 이미지
카스 번호:
72-18-4
한글명:
L-(+)-발린
동의어(한글):
L-(+)-발린;L-발린;발린
상품명:
L-Valine
동의어(영문):
L-VLA;Valin;L-Val;VALINE;2,3-D2);H-VAL-OH;L-VALINE;L-Val-OH;NSC 76038;VALINE, L-
CBNumber:
CB3381690
분자식:
C5H11NO2
포뮬러 무게:
117.15
MOL 파일:
72-18-4.mol

L-(+)-발린 속성

녹는점
295-300 °C (subl.)(lit.)
알파
28 º (c=8, 6N HCl)
밀도
1.23
굴절률
28 ° (C=8, HCl)
저장 조건
Store at RT.
용해도
H2O: 25 mg/mL
물리적 상태
powder
산도 계수 (pKa)
2.29(at 25℃)
색상
White
수소이온지수(pH)
5.5-6.5 (100g/l, H2O, 20℃)
optical activity
[α]20/D +27.0±0.5°, c = 5% in 5 M HCl
수용성
85 g/L (20 ºC)
최대 파장(λmax)
λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
Merck
14,9909
BRN
1721136
InChIKey
KZSNJWFQEVHDMF-BYPYZUCNSA-N
CAS 데이터베이스
72-18-4(CAS DataBase Reference)
NIST
Valine(72-18-4)

안전

위험품 표기 Xn
위험 카페고리 넘버 40
안전지침서 24/25-36-22
WGK 독일 3
RTECS 번호 YV9361000
TSCA Yes
HS 번호 29224995

L-(+)-발린 MSDS


2-Aminoisovaleric acid

L-(+)-발린 C화학적 특성, 용도, 생산

개요

Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.

화학적 성질

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.

용도

L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grai ns, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.

용도

valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.

정의

ChEBI: The L-enantiomer of valine.

Biosynthesis

Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.

Purification Methods

Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]

Nomenclature

According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.

L-(+)-발린 준비 용품 및 원자재

원자재

준비 용품


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