Ethyl 1,3-dithiane-2-carboxylate
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Ethyl 1,3-dithiane-2-carboxylate 속성
- 녹는점
- 19-21°C
- 끓는 점
- 75-77 °C/0.2 mmHg (lit.)
- 밀도
- 1.22 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.539(lit.)
- 인화점
- 130 °F
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 물리적 상태
- 투명한 액체
- 색상
- Colorless to Light yellow to Light orange
- 수용성
- 물과 약간 섞임.
- BRN
- 1424352
- InChI
- InChI=1S/C7H12O2S2/c1-2-9-6(8)7-10-4-3-5-11-7/h7H,2-5H2,1H3
- InChIKey
- ANEDZEVDORCLPM-UHFFFAOYSA-N
- SMILES
- S1CCCSC1C(OCC)=O
- CAS 데이터베이스
- 20462-00-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험 카페고리 넘버 | 10 | ||
|---|---|---|---|
| 안전지침서 | 26-36/37/39-45 | ||
| 유엔번호(UN No.) | UN 3272 3/PG 3 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 9-13 | ||
| 위험 등급 | 3 | ||
| 포장분류 | III | ||
| HS 번호 | 29349990 |
Ethyl 1,3-dithiane-2-carboxylate C화학적 특성, 용도, 생산
화학적 성질
clear yellowish liquid용도
Ethyl 1,3-dithiane-2-carboxylate is used in syn-selective aldol reactions. It undergoes asymmetric oxidation to give trans bis-sulfoxide. It is used to generate carbanon, which finds application in the preparation of alfa- keto esters.제조 방법
To a solution of BF3. Et2O (57.5 mL, 0.454 mmol) in CHC13 (180 mL) heated at reflux was added dropwise, over a 1h period, a solution of 1,3-propanedithiol (22.7 mL, 0.227 mmol), followed by ethyl diethoxyacetate (40 g, 0.227 mmol) in CHCl3 (40 mL). The resulting mixture was heated for 30 minutes, and then cooled to rt. The cooled solution was washed 2 times with water, once with saturated aqueous NaHC03, and then re-washed with water. The combined organic phases were dried over MgS04, then evaporated to give 41 g (94%) of Ethyl 1,3-dithiane-2-carboxylate as a yellow oi. Yield: 94%일반 설명
Ethyl 1,3-dithiane-2-carboxylate is an α-keto acid equivalent and bulky equivalent of acetate. It participates in syn-selective aldol reactions. It can be prepared from the reaction of ethyl diethoxyacetate and 1,3-propanedithiol in the presence of BF3/Et2O. Asymmetric oxidation of ethyl 1,3-dithiane-2-carboxylate by Modena protocol has been reported to afford trans bis-sulfoxide in 60% yield. Carbanion from ethyl 1,3-dithiane-2-carboxylate may be employed for the preparation of α-keto esters.Purification Methods
Dissolve the ester in CHCl3, wash with aqueous K2CO3, twice with H2O, dry over MgSO4, filter, evaporate and distil the residue. [Eliel & Hartman J Org Chem 37 505 1972, Seebach Synthesis 1 17 1969, Beilstein 19/7 V 227.]Ethyl 1,3-dithiane-2-carboxylate 준비 용품 및 원자재
원자재
Acetic acid, 2,2-dihydroxy-, ethyl ester
에틸 트리클로로아세테이트
디에톡시아세트에틸에스테르
1,3-프로판디티올
ETHYL DICHLOROACETATE
준비 용품
Ethyl 1,3-dithiane-2-carboxylate 공급 업체
글로벌( 120)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | +8613601750004 |
lizhi@pharoschem.com | China | 439 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shanghai Rlavie Technology Co ltd | +86-021-67759270 +8617717059219 |
sales@rlavie.com | China | 1030 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |