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에틸 사이아노아세테이트

에틸 사이아노아세테이트
에틸 사이아노아세테이트 구조식 이미지
카스 번호:
105-56-6
한글명:
에틸 사이아노아세테이트
동의어(한글):
시안초산에틸;에틸시아노아세트산;에틸사이아노아세테이트;에틸시아노아세트산;에틸 사이아노아세테이트;아세트산, 사이아노-, 에틸 에스터;에틸 사이아노에타노에이트
상품명:
Ethyl cyanoacetate
동의어(영문):
ECYA;CL079;usafkf-25;USAF kf-25;NCCH2COOC2H5;Cyanessigester;Ethylcyanacetat;Ethylcyanoacetat;ethylcyanacetate;2-cyanobutanoate
CBNumber:
CB9852660
분자식:
C5H7NO2
포뮬러 무게:
113.11
MOL 파일:
105-56-6.mol

에틸 사이아노아세테이트 속성

녹는점
-22 °C (lit.)
끓는 점
208-210 °C (lit.)
밀도
1.063 g/mL at 25 °C (lit.)
증기 밀도
3.9 (vs air)
증기압
1 mm Hg ( 67.8 °C)
굴절률
n20/D 1.418(lit.)
인화점
>230 °F
저장 조건
Store below +30°C.
용해도
20g/l
물리적 상태
Liquid
산도 계수 (pKa)
3.19±0.10(Predicted)
색상
Clear
수용성
20 g/L (20 ºC)
Merck
14,3786
BRN
605871
CAS 데이터베이스
105-56-6(CAS DataBase Reference)
NIST
Acetic acid, cyano-, ethyl ester(105-56-6)
EPA
Ethyl cyanoacetate (105-56-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 20/21/22-36/38
안전지침서 36/37-37/39-26
유엔번호(UN No.) 3276
WGK 독일 1
RTECS 번호 AG4110000
F 고인화성물질 10
자연 발화 온도 460 °C
TSCA Yes
HS 번호 2926 90 70
유해 물질 데이터 105-56-6(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 2000 mg/kg
기존화학 물질 KE-09030
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
1
1 1

에틸 사이아노아세테이트 MSDS


Ethyl 2-cyanoacetate

에틸 사이아노아세테이트 C화학적 특성, 용도, 생산

개요

Ethyl cyanoacetate is the ethyl ester of cyanoacetic acid. Ethyl cyanoacetate hydrolizes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol (and so it does under most physiological and environmental conditions), while in acid pH the half life is considerably longer.
Knoevenagel condensation of ethyl cyanoacetate with aldehyde is reported. Microwave enhanced Knoevenegal condensation reaction of ethyl cyanoacetate with an aldehyde, P2O5, piperidine and chlorobenzene is reported.

화학적 성질

Ethyl cyanoacetate is a colorless to straw colored liquid with a mild pleasant odor

용도

Reagent used in labelled pyrimidine and purine synthesis. Ethyl cyanoacetate is an ester. It may be used in the synthesis of ethyl glyoxylate.It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.

주요 응용

Ethyl cyanoacetate may be used in the synthesis of ethyl glyoxylate. It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.

제조 방법

Ethyl cyanoacetate can be prepared by the action of sodium or potassium cyanide on ethyl chloroacetate, and by the action of sodium cyanide on sodium chloroacetate, followed by esterification.

일반 설명

A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 210°F. May be toxic by ingestion. Used to make other chemicals.

공기와 물의 반응

Slightly soluble in water.

반응 프로필

Ethyl cyanoacetate is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

위험도

Toxic by ingestion and inhalation.

건강위험

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

화재위험

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

oison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Combustible when exposed to heat or flame; can react with oxidzing materials. Wdl react with water or steam to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN-. See also NITRILES.

잠재적 노출

A nitrile used to manufacture dyes, pharmaceuticals, and other chemicals.

운송 방법

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Purification Methods

Shake the ester several times with aqueous 10% Na2CO3, wash it well with water, dry with Na2SO4 and fractionally distil it. [Beilstein 2 IV 1889.]

비 호환성

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Reacts with moisture, water, and steam, forming toxic fumes.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

에틸 사이아노아세테이트 준비 용품 및 원자재

원자재

준비 용품

5-CYANO-6-HYDROXY-4-METHOXYMETHYL-2-METHYLPYRIDINE ETHYL 2-CYANO-3-METHYL-2-PENTENOATE ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE 트리암테렌 2-(4,6-diamino-1,3,5-triazin-2-yl)acetic acid 알로퓨리놀 2-Amino-4-trifluoromethylbenzonitrile 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER 1-ETHYL-1-METHYLSUCCINIC ACID Disperse Yellow S-3GL 6-AMINO-2-METHYLTHIO-3-METHYLURACIL 1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE 6-Aminouracil 2-CHLORO-4-METHYLQUINOLINE-3-CARBONITRILE ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 6-AMINO-2-MERCAPTO-PYRIMIDIN-4-OL Ethyl α-cyanoacrylate instantaneous adhesive 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 3-AMINO-2,2-DIMETHYL-1-PROPANOL 2-AMINO-5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE 히드로염화 아밀로리드 5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 6-Amino-1-methyluracil 2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE 6-CHLORO-5-CYANO-4-METHOXYMETHYL-3-NITRO-2-PICOLINE 4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE GUANINE SULFATE 다카바진 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 6-AMINO-1-METHYL-5-NITROSOURACIL 6-AMINO-3-METHYLURACIL Ethyl 3-ethoxy-3-iminopropionate hydrochloride 5,6-Diamino-1-methyluracil

에틸 사이아노아세테이트 공급 업체

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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
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+8618017249410 +86-021-57951555
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
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career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1714 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

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