염산구아니딘
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염산구아니딘 속성
- 녹는점
- 180-185 °C(lit.)
- 밀도
- 1.18 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.465
- 저장 조건
- room temp
- 용해도
- H2O: 6 M, 투명, 무색
- 물리적 상태
- 크리스탈
- 색상
- 흰색에서 약간 노란색
- 수소이온지수(pH)
- 4.5-5.5 (100g/l, H2O, 20℃)
- 냄새
- 냄새 없는
- pH 범위
- 4.5 - 6.0 at 573 g/l at 25 °C
- 수용성
- 2280g/L(20℃)
- 감도
- Hygroscopic
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.040
λ: 280 nm Amax: 0.025
- Merck
- 14,4562
- BRN
- 3591990
- 안정성
- 안정적인. 흡습성. 강한 산화제와 호환되지 않습니다.
- InChIKey
- PJJJBBJSCAKJQF-UHFFFAOYSA-N
- CAS 데이터베이스
- 50-01-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/38 | ||
안전지침서 | 26-36-22 | ||
WGK 독일 | 1 | ||
RTECS 번호 | MF4300000 | ||
F 고인화성물질 | 3-10 | ||
TSCA | Yes | ||
HS 번호 | 29252000 | ||
독성 | LD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg | ||
기존화학 물질 | KE-18111 |
염산구아니딘 C화학적 특성, 용도, 생산
물성
3개의 질소원자에 의해 결합되고, 산성의 양전하가 분산되어 안정화되므로 구아니딘은 강한 염기성을 나타낸다 (pKa = 12.5). 생리적 조건에서는 양성자화된 +1가의 양이온으로 존재한다.개요
구아니딘(guanidine)은 구조식이 HN=C(NH2)2의 구조를 가진 유기 화합물이다. 강한 염기성을 가진 결정성의 고체로, 구아닌을 분해해 얻을 수있다. 또한 단백질의 대사에 의해 생성되고 소변 중에서도 검출된다.용도
플라스틱이나 폭약의 원료로 사용된다. 또한 수소결합 을 만들기 쉬운 성질때문에 염산이나 소금에 의해 단백질이 변성되는 것을 방지하는데 사용된다 (GdmCl로 알려져 있다). 화석연료의 대체연료로 이용하는 연구도 진행되고있다. 유도체는 유기합성을 통해 강한 염기로 사용된다.화학적 성질
Guanidine hydrochloride, a strong organic base, appears as white crystal powder or yellowish lumps that are almost insoluble in acetone, benzene, and ether. In physiological pH, it exists primarily as guanidium ions. It is a natural byproduct of protein metabolism found in urine and is commonly used in protein denaturation in laboratory research.용도
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.제조 방법
The process for preparing guanidine hydrochloride is as follows:Step 1: Fritting - Combine dicyandiamide and ammonium chloride in a reactor with a 1:1.27 weight ratio and carry out a frit reaction at 170-230°C to obtain crude guanidine hydrochloride.
Step 2: Dissolving - Dissolve the crude guanidine hydrochloride in water at a 1:1 ratio at normal temperature. Then, add ammonium salt alkaloid in an amount determined by the ammonium salt content in the crude guanidine hydrochloride.
Step 3: Filtering - Remove raw materials and reaction by-products with filtration.
Step 4: Dehydrating - Dehydrate the filtered ground mother liquor at a high temperature.
Step 5: Crystallizing - Cool the supersaturated solution, concentrate, and crystallize to obtain high-purity guanidine hydrochloride.
Step 6: Repeat steps 2-5 and add dicyandiamide in the reactor with the guanidine hydrochloride to carry out frit reaction at 170-230°C for 3-4 hours to obtain even higher purity guanidine hydrochloride. This step can be repeated several times if needed.
Step 7: To obtain higher purity guanidine hydrochloride, subject the guanidine hydrochloride obtained in step 5 to steps 2-5 again, with the water ratio in step 2 adjusted to 1.5:1. This step can be repeated numerous times as required.
정의
ChEBI: Guanidine Hydrochloride is an aminocarboxamidine, the parent compound of the guanidines. It is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism.일반 설명
Guanidine hydrochloride (GdnHCl) is a well-known protein and enzyme denaturant. It is a small molecule and hydroscopic in nature. It is used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.위험도
Toxic by ingestion, evolves hydrogen chloride fumes on heating.Purification Methods
Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.]염산구아니딘 준비 용품 및 원자재
원자재
준비 용품
2-Amino-5-nitropyrimidine
2,5-Diamino-4,6-dichloropyrimidine
구아니딘 탄산염
5-AMINO-2-FLUOROPYRIMIDINE
shark soft bone preparation
2-Amino-4-chloro-6-methylpyrimidine
2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
2-Amino-6-hydroxypyrimidin-4(3H)-one ,97%
2,4-디아미노-1,3,5-트리아진
5-Amino-2-chloropyrimidine
2-Amino-5-pyrimidinecarboxyaldehyde
히드로염화 아밀로리드
9-ETHYLGUANINE
2-Aminopyrimidine
7-(TRIFLUOROMETHYL)-3-IODOIMIDAZO[1,2-A]PYRIMIDINE
6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE
포르마미딘 하이드로클로라이드
3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine
2-amino-6-chloropyrimidin-4(3H)-one
2-Chloro-5-nitropyrimidine
2-Amino-6-methyl-4-pyrimidinol
GUANINE SULFATE
구아니딘포스페이트
2-AMINO-6-HYDROXY-PYRIMIDINE-4-CARBOXYLIC ACID
2,4-디아미노피리미딘
2-Aminopyrimidine-5-carboxylic acid
ISOXANTHOPTERIN
염산구아니딘 공급 업체
글로벌( 838)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 |
dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
Jiangsu Boquan Biotechnology Co., Ltd. | +86-18168774353 |
boquanshengwu003@boquansw.com | China | 248 | 58 |
XuZhou Magic Biotechnology Co., Ltd. | +undefined13921770081 |
SVP01@magicbiotech.cn | China | 92 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 931 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12465 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
염산구아니딘 관련 검색:
구아니딘 나이트레이트 L-(+)-아르기닌 모노수화염화물 염산 메트포르민 클로르헥시딘 포르마미딘 하이드로클로라이드 4-구아니디노벤조산 염화수소산염 염화 암모늄 및 포름알데히드가 포함된 시아노구아니딘 폴리머 1,3-디아미노구아니딘 모노하이드로클로라이드 염산구아니딘
Topotecan hydrochloride
[(2,6-DICHLOROPHENYL)ACETYL]GUANIDINE HYDROCHLORIDE
Guanidinium sulphate
Cyclohexylamine hydrochloride
BuforMin Hydrochloride
2,6-DICHLOROPHENYLACETAMIDE
Benzeneacetamide, N-(aminoiminomethyl)-2-chloro-
2,6-DICHLOROPHENYLACETIC ACID METHYL ESTER
2,6-Dichlorophenylacetic acid