Valspodar

Valspodar 구조식 이미지
카스 번호:
121584-18-7
상품명:
Valspodar
동의어(영문):
Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
CBNumber:
CB71116624
분자식:
C63H111N11O12
포뮬러 무게:
1214.62
MOL 파일:
121584-18-7.mol

Valspodar 속성

녹는점
143-145°C
알파
D20 -255.1° (c = 0.5 in CHCl3)
끓는 점
1290.1±65.0 °C(Predicted)
밀도
1.015±0.06 g/cm3(Predicted)
저장 조건
-20°C
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)
12.45±0.70(Predicted)
물리적 상태
가루
색상
흰색에서 베이지색
InChIKey
YJDYDFNKCBANTM-QCWCSKBGSA-N

안전

WGK 독일 3

Valspodar C화학적 특성, 용도, 생산

개요

PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.

화학적 성질

White Solid

용도

Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.

Cytotoxicity

Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].

Valspodar 준비 용품 및 원자재

원자재

준비 용품


Valspodar 공급 업체

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