글리세릴 모노스테아레이트

글리세릴 모노스테아레이트
글리세릴 모노스테아레이트 구조식 이미지
카스 번호:
31566-31-1
한글명:
글리세릴 모노스테아레이트
동의어(한글):
글리세릴모노스테아레이트;글리세릴모노스테아레이트(GLYCERYLMONOSTEARATE)
상품명:
Glyceryl monostearate
동의어(영문):
GLYCERYL STEARATE;GLYCEROL MONOSTEARATE;GMS;Monostearin;GLYCERYL STEARATE SE;1-STEAROYL-RAC-GLYCEROL;1-MONOSTEARIN;Glycerol Monostearate HPMC;admul;DL-ALPHA-STEARIN
CBNumber:
CB7234695
분자식:
C21H42O4
포뮬러 무게:
358.56
MOL 파일:
31566-31-1.mol

글리세릴 모노스테아레이트 속성

녹는점
78-81 °C
끓는 점
410.96°C (rough estimate)
밀도
0.9700
굴절률
1.4400 (estimate)
저장 조건
Sealed in dry,Store in freezer, under -20°C
용해도
Soluble in hot ethanol, ether, chloroform, hot acetone, mineral oil, and fixed oils. Practically insoluble in water, but may be dispersed in water with the aid of a small amount of soap or other surfactant.
물리적 상태
가루
색상
순백색 또는 크림색의 왁스 같은 고체
냄새
희미한 냄새
수용성
뜨거운 유기 용매에 용해됩니다.뜨거운 물에 용해됩니다. 에탄올에 약간 용해됩니다. 지방족 용매에 불용성.
Merck
14,4489
노출 한도
ACGIH: TWA 10 mg/m3; TWA 3 mg/m3
InChI
InChI=1S/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H3
InChIKey
VBICKXHEKHSIBG-UHFFFAOYSA-N
SMILES
C(OCC(CO)O)(=O)CCCCCCCCCCCCCCCCC
CAS 데이터베이스
31566-31-1(CAS DataBase Reference)
EPA
Glyceryl monostearate (31566-31-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
WGK 독일 1
TSCA Yes
HS 번호 2918199890
독성 LD50 ipr-mus: 200 mg/kg NTIS** AD277-689
기존화학 물질 KE-26398
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
NFPA 704
1
0 0

글리세릴 모노스테아레이트 C화학적 특성, 용도, 생산

개요

§184.1324(a) Glyceryl monostearate, also known as monostearin, is a mixture of variable proportions of glyceryl monostearate (C21H42O4), and glyceryl esters of fatty acids present in commercial stearic acid. Glyceryl monostearate is prepared by glycerolysis of certain fats or oils that are derived from edible sources or by esterification, with glycerin, of stearic acid that is derived from edible sources.

화학적 성질

While the names glyceryl monostearate and mono- and diglycerides are used for a variety of esters of long-chain fatty acids, the esters fall into two distinct grades:
40–55 percent monoglycerides The PhEur 6.0 describes glyceryl monostearate 40–55 as a mixture of monoacylglycerols, mostly monostearoylglycerol, together with quantities of di- and triacylglycerols. It contains 40–55% of monoacylglycerols, 30–45% of diacylglycerols, and 5–15% of triacylglycerols. This PhEur grade corresponds to mono- and di-glycerides USP– NF, which has similar specifications (not less than 40% monoglycerides).
90 percent monoglycerides The USP32–NF27 describes glyceryl monostearate as consisting of not less than 90% of monoglycerides of saturated fatty acids, chiefly glyceryl monostearate (C21H42O4) and glyceryl monopalmitate (C19H38O4).
The commercial products are mixtures of variable proportions of glyceryl monostearate and glyceryl monopalmitate.
Glyceryl monostearate is a white to cream-colored, wax-like solid in the form of beads, flakes, or powder. It is waxy to the touch and has a slight fatty odor and taste.

용도

Commercially, glyceryl monostearate is synthesized from mono triglycerides, diglycerides, and triglycerides of palmitic acid and stearic acid. Glycerol monostearate is often used as an emulsifier to stabilize the product and prevent separation. It is found in many personal care products such as moisturizers, eye creams, sunscreens, cosmetics, and hand creams. Glycerol monostearate is also used as a preservative.

용도

glyceryl monostearate (glycerin monostearate; glyceryl stearate) is widely used in cosmetics. It is an emulsifying and solubilizing ingredient, dispersing agent, emollient, formula stabilizer, and surface-action agent. employed in baby creams, face masks, foundation, and hand lotions, it is often derived from hydrogenated soybean oil. glyceryl monostearate has little or no G toxicity.

생산 방법

Glyceryl monostearate is prepared by the reaction of glycerin with triglycerides from animal or vegetable sources, producing a mixture of monoglycerides and diglycerides. The diglycerides may be further reacted to produce the 90% monoglyceride grade. Another process involves reaction of glycerol with stearoyl chloride.
The starting materials are not pure substances and therefore the products obtained from the processes contain a mixture of esters, including palmitate and oleate. Consequently, the composition, and therefore the physical properties, of glyceryl monostearate may vary considerably depending on the manufacturer.

정의

An intermediate chemical.

Pharmaceutical Applications

The many varieties of glyceryl monostearate are used as nonionic emulsifiers, stabilizers, emollients, and plasticizers in a variety of food, pharmaceutical, and cosmetic applications. It acts as an effective stabilizer, that is, as a mutual solvent for polar and nonpolar compounds that may form water-in-oil or oil-in-water emulsions.These properties also make it useful as a dispersing agent for pigments in oils or solids in fats, or as a solvent for phospholipids, such as lecithin.
Glyceryl monostearate has also been used in a novel fluidized hot-melt granulation technique for the production of granules and tablets.
Glyceryl monostearate is a lubricant for tablet manufacturing and may be used to form sustained-release matrices for solid dosage forms. Sustained-release applications include the formulation of pellets for tablets or suppositories, and the preparation of a veterinary bolus. Glyceryl monostearate has also been used as a matrix ingredient for a biodegradable, implantable, controlledrelease dosage form.
When using glyceryl monostearate in a formulation, the possibility of polymorph formation should be considered. The aform is dispersible and foamy, useful as an emulsifying agent or preservative. The denser, more stable, b-form is suitable for wax matrices. This application has been used to mask the flavor of clarithromycin in a pediatric formulation.

Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Safety

Glyceryl monostearate is widely used in cosmetics, foods, and oral and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, IP): 0.2 g/kg

저장

If stored at warm temperatures, glyceryl monostearate increases in acid value upon aging owing to the saponification of the ester with trace amounts of water. Effective antioxidants may be added, such as butylated hydroxytoluene and propyl gallate.
Glyceryl monostearate should be stored in a tightly closed container in a cool, dry place, and protected from light.

비 호환성

The self-emulsifying grades of glyceryl monostearate are incompatible with acidic substances.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules and tablets; ophthalmic, otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
If glyceryl monostearate is produced from animal fats (tallow), there may be additional regulatory requirements that the source be free of contamination from bovine spongiform encephalopathy.

글리세릴 모노스테아레이트 준비 용품 및 원자재

원자재

준비 용품


글리세릴 모노스테아레이트 공급 업체

글로벌( 494)공급 업체
공급자 전화 이메일 국가 제품 수 이점
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 50002 58
Hebei Yime New Material Technology Co., Ltd.
+86-66697723 +86-17703311139
admin@china-yime.com China 562 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666
sales@hbmojin.com China 12409 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024
hibo06@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763
info@tnjchem.com China 2989 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1011 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29919 58

글리세릴 모노스테아레이트 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved