나이트로푸란토인
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나이트로푸란토인 속성
- 녹는점
- 268°C
- 끓는 점
- 380.75°C (rough estimate)
- 밀도
- 1.5824 (rough estimate)
- 굴절률
- 1.6700 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- DMF: 용해성50mg/mL
- 산도 계수 (pKa)
- 7.2(at 25℃)
- 물리적 상태
- 수정 같은
- 색상
- 노란색
- 수용성
- 19&C에서 <0.01g/100mL
- 감도
- Light Sensitive & Hygroscopic
- 최대 파장(λmax)
- 358nm(MeOH)(lit.)
- Merck
- 14,6599
- BRN
- 893207
- BCS Class
- 2
- 안정성
- 안정성 안정적이지만 빛에 민감합니다. 타기 쉬운. 강한 산화제, 강알칼리, 강산과 호환되지 않습니다. 스테인레스 스틸 및 알루미늄을 제외한 대부분의 금속과 접촉하면 분해됩니다.
- CAS 데이터베이스
- 67-20-9(CAS DataBase Reference)
- IARC
- 3 (Vol. 50) 1990
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-42/43 | ||
안전지침서 | 22-36/37-45 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | MU2800000 | ||
TSCA | Yes | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 67-20-9(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 604mg/kg |
나이트로푸란토인 C화학적 특성, 용도, 생산
화학적 성질
lemon yellow crystalline powderIndications
Like nitrofurazone, nitrofurantoin is an effective drug that acts on a number of Grampositive and Gram-negative microorganisms (staphylococci, streptococci, dysentery bacillus, colon bacillus, paratyphoid bacillus, and others). It is primarily used for treating infectious diseases of the urinary tract (pyelitis, pyelonephritis, cystitis, urethritis). Synonyms of this drug are furadonin, ituran, phenurin, urolong, cistofuran, nitrofurin, and many others.정의
ChEBI: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.Antimicrobial activity
It is active against almost all the common urinary pathogens, except Proteus mirabilis. It is bactericidal.It antagonizes the activity of nalidixic acid and other quinolones in vitro, but this combination is unlikely to be used clinically.
원료
Surprisingly for an agent that has been used for so long, resistance remains uncommon. R-factor-mediated resistance has been reported, but this appears to be very unusual. The mechanism of resistance seems to be a decreased nitroreductase activity in the target organism.There is cross-resistance within the nitrofuran group, but none with antibiotics of other chemical classes.
일반 설명
Odorless lemon yellow crystals or fine yellow powder. Bitter taste.공기와 물의 반응
Insoluble in water.반응 프로필
Nitrofurantoin is sensitive to light. Nitrofurantoin is incompatible with alkalis. Nitrofurantoin is also incompatible with strong oxidizers and strong acids. Nitrofurantoin decomposes on contact with metals other than stainless steel and aluminum.위험도
Questionable carcinogen.화재위험
Flash point data for Nitrofurantoin are not available; however, Nitrofurantoin is probably combustible.Pharmaceutical Applications
A synthetic compound available only for oral administration. There are three formulations, differing in their crystalline nature: microcrystalline, macrocrystalline, and a delayedrelease preparation containing a combination of the two. The macrocrystalline form is said to be less liable to give rise to the most common adverse event, nausea. However, pharmacokinetic and clinical trial evidence for this assertion is not very strong.It is slightly soluble in water (c. 200 mg/L) but more so in dilute alkali. Solubility in ethanol is modest (500 mg/L), but the compound dissolves very well in dimethylformamide (80 g/L). If packaged in light-resistant containers and kept at room temperature, it is stable for more than 5 years. The yellow solution should be kept in the dark.
Clinical Use
Acute dysuria and frequencyBacteriuria in pregnancy
Prophylaxis of recurrent cystitis (reduced dosage)
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects: peripheral motor nerve recording changes, ataxia, changes in urine composition, and hemolysis with or without anemia. Human reproductive effects by ingestion: spermatogenesis. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.나이트로푸란토인 준비 용품 및 원자재
원자재
하이드라진 수화물
Acetone semicarbazone
아세톤
Semicarbazide
5-니트로푸르푸릴리덴 디(아세테이트)
푸르푸랄
모노클로로초산에틸
1-아미노하이단토인
NIFUROXIME
헵탄알
준비 용품
나이트로푸란토인 공급 업체
글로벌( 469)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5866 | 58 |
Zibo Shiji Zhonglian Medical Technology Co., Ltd. | 15069388126 15069388126 |
sales@sjzlpharm.com | China | 65 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
나이트로푸란토인 관련 검색:
푸란 나이트로푸란토인
Ciprofloxacin hydrochloride
Levofloxacin HCL Capsule
nifurtoinol
nifurfoline
2-NP-AMOZ
1-AMINOHYDANTOIN
NITROFURANTOIN, SODIUM SALT,nitrofurantoin sodium
Nitrofurantoin1-Hydrate,Nitrofurantoin monohydrate
1-AMINO-IMIDAZOLIDIN-2,4-DIONE
1-AMINO-IMIDAZOLIDIN-2,4-DIONE (AHD)
3-AMINO-5-MORPHOLIN-4-YLMETHYL-OXAZOLIDIN-2-ONE-D5
FU
NITROFURANTOIN RELATED COMPOUND A (25 MG) (N-(AMINOCARBONYL)-N-[([5-NITRO-2-FURANYL]-METHY- LENE)-AMINO]-GLYCINE)
NITROFURANTOIN RELATED COMPOUND A (25 MG) (N-(AMINOCARBONYL)-N-[([5-NITRO-2-FURANYL]-METHY-LENE)-AMINO]-GLYCINE)