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푸란

푸란
푸란 구조식 이미지
카스 번호:
110-00-9
한글명:
푸란
동의어(한글):
퓨란;푸란;다이바이닐 옥사이드;다이바이닐렌 옥사이드;옥사사이클로펜타다이엔
상품명:
Furan
동의어(영문):
ACF;OXOL;axole;Oxole;FURAN;tetrol;Furane;Pyrane;Tetrole;furan00
CBNumber:
CB9852796
분자식:
C4H4O
포뮬러 무게:
68.07
MOL 파일:
110-00-9.mol

푸란 속성

녹는점
-85.6 °C
끓는 점
67 °C10 mm Hg(lit.)
밀도
0.936 g/mL at 25 °C(lit.)
증기 밀도
2.35 (vs air)
증기압
1672 mm Hg ( 55 °C)
굴절률
n20/D 1.5070(lit.)
인화점
160 °F
저장 조건
Store below +30°C.
용해도
alcohols: freely soluble
물리적 상태
Liquid
색상
Clear colorless to yellow
Odor Threshold
9.9ppm
폭발한계
2.3-14.3%(V)
수용성
insoluble
감도
Air & Light Sensitive
Merck
14,4296
BRN
103221
안정성
Stable. Substances to be avoided include strong oxidising agents, acids, peroxides and oxygen. Highly flammable; can form explosive mixtures with air.
InChIKey
YLQBMQCUIZJEEH-UHFFFAOYSA-N
CAS 데이터베이스
110-00-9(CAS DataBase Reference)
NIST
Furan(110-00-9)
IARC
2B (Vol. 63) 1995
EPA
Furan (110-00-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F+
위험 카페고리 넘버 45-12-19-20/22-38-48/22-52/53-68
안전지침서 53-45-61-
유엔번호(UN No.) UN 2811 6.1/PG 2
WGK 독일 3
RTECS 번호 OB3870000
F 고인화성물질 8-9-23
자연 발화 온도 390 °C
TSCA Yes
HS 번호 2932 19 00
위험 등급 3
포장분류 I
유해 물질 데이터 110-00-9(Hazardous Substances Data)
독성 LC (in air) in rats: 30400 ppm (Henderson)
기존화학 물질 KE-17309
중점관리물질 필터링 별표2-33
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H224 극인화성 액체 및 증기 인화성 액체 구분 1 위험
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
H373 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음 특정 표적장기 독성 - 반복 노출 구분 2 경고 P260, P314, P501
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P273 환경으로 배출하지 마시오.
P281 요구되는 개인 보호구를 착용하시오
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
4
2 1

푸란 C화학적 특성, 용도, 생산

개요

Furan occurs naturally in oils distilled from rosin containing pinewood. In addition, many natural foods contain the furan ring structure and substituted furans may be formed through cooking of simple carbohydrates. Furan is also found in tobacco smoke as well as wood smoke and gas emissions from gasoline and diesel engines. Furan has also been detected in industrial effluents and can be emitted to the air from petroleum refineries and coal-mining and gasification plants.

화학적 성질

Furan is a cyclic dienic ether stabilized by benzene-like resonance. Because of its conjugated unsaturation and heterocyclic atom, furan will undergo many types of reactions. It is, therefore, of interest as a chemical intermediate for pharmaceuticals, insecticides and fine chemicals. The heterocyclic oxygen atom in a ring with conjugated unsaturation gives furan a combination of ether, aromatic and olefinic characteristics. This polyfunctionality permits it to undergo a variety of reactions. Compared to benzene, the furan ring has greater reactivity, and is more susceptible to cleavage, thus resembling the vinyl ethers. Like the vinyl ethers, the furan ring is cleaved by aqueous acids. This reaction is accompanied by resinification .

화학적 성질

Furan is a colorless liquid; turns brown on standing. Strong ethereal odor.

용도

Furan is a valuable chemical intermediate for pharmaceuticals, insecticides, and other organic compounds. The furan ring is cleaved by aqueous acid which can lead to polymer formation.

용도

Furan is a five-membered heterocyclic aromatic ring. Furan is used as a building block for the preparation of many heterocyclic compounds.

용도

In organic syntheses.

용도

Furan is used as an intermediate in organicsynthesis.

정의

A heterocyclic compound.

정의

A heterocyclic liquid organic compound. Its five-membered ring contains four carbon atoms and one oxygen atom. The structure is characteristic of some monosaccharide sugars (furanoses).

정의

furan: A colourless liquid compound,C4H4O; r.d. 0.94; m.p. –86°C;b.p. 31.4°C. It has a five-memberedring consisting of four CH2 groupsand one oxygen atom.

일반 설명

Furan is a stable, colourless chemical liquid. It is highly flammable and forms explosive mixtures with air. It is incompatible with many other chemical substances, for example, strong oxidising agents, acids, peroxides, and oxygen. Furan is produced commercially by decarbonylation of furfural. It is used mainly in the production of tetrahydrofuran, thiophene, and pyrrole. It also occurs naturally in certain woods and during the combustion of coal and is found in engine exhausts, wood smoke, and tobacco smoke.

공기와 물의 반응

Highly flammable. When uninhibited, Furan forms explosive peroxides on exposure to air. Insoluble in water.

반응 프로필

Furan is sensitive to heat and may turn brown upon standing. Furan may be light sensitive. When uninhibited, Furan forms explosive peroxides on exposure to air. Furan may react with oxidizers, acids, peroxides and oxygen. Furan resinifies on evaporation or when in contact with mineral acids, but Furan is stable in alkalis. .

위험도

Flammable, dangerous fire risk, flammable limits 2–24%, forms peroxides on exposure to air. Absorbed by skin. Possible carcinogen.

건강위험

The vapors are narcotic. Acute exposure to Furan by inhalation may involve both reversible and irreversible changes. Acute exposure by ingestion or skin absorption, as well as chronic exposure, are associated with high toxicity.

건강위험

Furan is a highly toxic compound. Inhalationof its vapors can cause acute pulmonaryedema and lung damage. The intraperitonealLD50 value in rodents is between 5 and7 mg/kg. The inhalation LC50 value in micefor a 1-hour exposure is 120 mg/m3.

화재위험

Very dangerous, upon exposure to heat or flame. Furan may form unstable peroxides on exposure to air. Contact with acids can initiate a violent, heat producing reaction. Avoid acids, oxidizing agents. Upon standing in air, Furan may form unstable peroxides.

Safety Profile

Confirmed carcinogen. Poison by inhalation and intraperitoneal routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. A narcotic. Mutation data reported. The exposure concentration limit of 10 ppm together with its low boiling point requires that adequate ventilation be provided in areas where ths chemical is handled. Contact with liquid must be avoided since this chemical can be absorbed through the skin. Washing thoroughly with soap and water followed by prolonged rinsing should be done immedlatelp after accidental contact. A very dangerous fire hazard when exposed to heat or flame; can react with oxidzing materials. Unstabdized, it may form unstable peroxides on exposure to air and should always be tested before ddlation. Washing with an aqueous solution of ferrous sulfate slightly acidified with sodum bisulfate will remove these peroxides. Confirm by test. Contact with acids can initiate a violent exothermic reaction. Moderate explosion hazard when exposed to flame. Furan's low bohg point makes it easy to obtain explosive concentrations of the vapor in inadequately ventilated areas. To fight fire, use CO2, dr). chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also PEROXIDES.

잠재적 노출

Furan is used as a chemical intermedi ate in the production of herbicides and pharmaceuticals; for making tetrahydrofuran; in formation of lacquers; as a sol vent for resins in organic synthesis, especially for pyrrole, thiophene.

Carcinogenicity

Furan is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

환경귀착

Furan may be released to the environment as a waste industrial product or from unintentional or accidental releases. If released to soil, it is expected to volatilize. If released to water, furan is not expected to adsorb to suspended particles and sediment and is likely to volatilize to ambient air. Sulfate-reducing bacteria can degrade furan. However, under nonsulfate-reducing conditions, biodegradation in soil and water is expected to be slow. In the air, furan will exist as a vapor and will be subject to degradation by reacting with hydroxyl radicals.

운송 방법

UN2389 Furan, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Shake it with aqueous 5% KOH, dry it with CaSO4 or Na2SO4, then distil it under nitrogen, from KOH or sodium, immediately before use. A trace of hydroquinone could be added as an inhibitor of oxidation. [Beilstein 17 H 27, 17 I 16, 17 II 34, 17/1 V 291.]

Toxicity evaluation

Furan can cause eye, skin, and mucus membrane irritation, burning sensation and, in severe cases, corrosion. If inhaled, furan may produce pulmonary edema and bronchiolar necrosis. When absorbed, furan can cause central nervous system (CNS) depression to the point of narcosis and tonic seizures.
Furan is metabolized by the cytochrome P450 enzymes in the liver and other tissues. Furan is metabolized to cis-2- butene-1,4-dial. This active metabolite is acutely toxic to liver cells. The furan ring undergoes oxidative cleavage and forms highly reactive furan radical cations or epoxides, which react directly with cellular nucleophiles. These reactive metabolites may react directly with deoxyribonucleic acid (DNA) or with cellular proteins to produce disruption of cellular functions and cell death. Chronic cell death and regeneration produced by chronic furan exposure may be a significant factor in the carcinogenicity potential of the chemical. In addition, there is some evidence to suggest that the reactive metabolites of furan may induce mutations in cellular genes.

비 호환성

May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, amines, strong bases, reducing agents. Unless stabilized with an inhibitor, air exposure forms unstable peroxides.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern ing storage, transportation, treatment, and waste disposal.

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