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아세톤

아세톤
아세톤 구조식 이미지
카스 번호:
67-64-1
한글명:
아세톤
동의어(한글):
아세톤;디메틸포름알데히드;베타-케토프로판;프로파논엔;2-프로파논;디메틸케톤;디메틸케톤,2-프로파논;메틸케톤;피로아세트에테르;다이메틸 케톤;다이메틸포름알데하이드;메틸 케톤;피로아세트 에테르
상품명:
Acetone
동의어(영문):
aceton;Acetone;Sasetone;Propanon;(CH3)2CO;ai3-01238;AcetoneGr;ACETONE,NF;2-Propanon;Acetone oil
CBNumber:
CB3130928
분자식:
C3H6O
포뮬러 무게:
58.08
MOL 파일:
67-64-1.mol

아세톤 속성

녹는점
-94 °C(lit.)
끓는 점
56 °C760 mm Hg(lit.)
밀도
0.791 g/mL at 25 °C(lit.)
증기 밀도
2 (vs air)
증기압
184 mm Hg ( 20 °C)
굴절률
n20/D 1.359(lit.)
FEMA
3326 | ACETONE
인화점
1 °F
저장 조건
Store at RT.
용해도
Miscible with water and with ethanol (96 per cent).
산도 계수 (pKa)
19.3(at 25℃)
물리적 상태
Liquid
색상
Colorless, invisible vapor
Specific Gravity
0.79 (25/25℃)
수소이온지수(pH)
5-6 (395g/l, H2O, 20°C)
상대극성
0.355
냄새
Characteristic pungent odor detectable at 33 to 700 ppm (mean = 130 ppm)
Odor Threshold
42ppm
폭발한계
2.6-12.8%(V)
수용성
soluble
Merck
14,66
JECFA Number
139
BRN
63580
Henry's Law Constant
2.27 at 14.9 °C, 3.03 at 25 °C, 7.69 at 35.1 °C, 11.76 at 44.9 °C (Betterton, 1991)
노출 한도
TLV-TWA 1780 mg/m3 (750 ppm), STEL 2375 mg/m3 (ACGIH); 10 h–TWA 590 mg/m3 (250 ppm); IDLH 20,000 ppm (NIOSH).
CAS 데이터베이스
67-64-1(CAS DataBase Reference)
NIST
Acetone(67-64-1)
EPA
Acetone (67-64-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,Xi,T
위험 카페고리 넘버 11-36-66-67-39/23/24/25-23/24/25
안전지침서 9-16-26-45-36/37-7
유엔번호(UN No.) UN 1090 3/PG 2
WGK 독일 3
RTECS 번호 AL3150000
F 고인화성물질 3-10
자연 발화 온도 465 °C
TSCA Yes
위험 등급 3
포장분류 II
HS 번호 29141100
유해 물질 데이터 67-64-1(Hazardous Substances Data)
독성 LD50 in rats: 10.7 ml/kg orally (Smyth)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H336 졸음 또는 현기증을 일으킬 수 있음 특정표적장기 독성 물질(1회 노출);마취작용 구분 3 경고 P261, P271, P304+P340, P312,P403+P233, P405, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
3
1 0

아세톤 MSDS


Acetone

아세톤 C화학적 특성, 용도, 생산

용도

아세톤은 물질을 녹여 용액으로 만드는 매우 중요한 용매(Solvent)중 하나로 주로 아세톤은 플라스틱과 합성 섬유에 효과적인 용매로 사용되며, 2010년 세계 석유화학 보고서에 따르면 세계에서 제작되는 아세톤의 1/3이 용매로 사용되었습니다.
또한 유기 합성의 원료로도 사용되어 용매 또는 시너 등으로 사용되는 다이아세톤 알코올(Diacetone Alcohol)과 같은 화합물의 제작에도 사용되며, 실험실에서는 비커와 같은 유리 제품의 최종 세척전 잔류물과 고형물을 제거하기 위한 세정제로 많이 사용됩니다.
물, 알코올(Alcohol), 에테르(Ether) 등 대부분의 용매와 잘 섞이며, 실생활에서는 이와 같은 성질을 이용하여 페인트나 매니큐어와 같이 물로 세척되지 않는 물질을 세척하는데 사용됩니다.
아세톤은 인화성이 매우 강하기 때문에 불이 잘 붙으며, 폭발의 위험까지 있어 취급시 화기에 멀리 하는 것을 권장합니다.
또한 장기적인 피부 접촉이 있을 경우 심한 염증을 일으킬 수 있는 독성물질에 속합니다.

개요

Acetone is a flammable, colorless liquid with a pleasant odor. It is used widely as an organic solvent and in the chemical industry. It is the simplest ketone, which also goes by the name dimethyl ketone (DMK). Acetone was originally referred to as pyroacetic spirit because it was obtained from the destructive distillation of acetates and acetic acid.

화학적 성질

Acetone, CH3COCH3, also known as 2-propanone and dimethylketone, is a colorless, volatile,flammable liquid that boils at 56°C (133 OF). It is misciblewith water and is oftenused as a solventin the manufacture of lacquers and paints.

물리적 성질

Clear, colorless, liquid with a sweet, fragrant odor. Sweetish taste. Odor threshold concentrations ranged from 42 ppmv (Nagata and Takeuchi, 1990) to 100 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 48 mg/m3 (20 ppmv) and 78 mg/m3 (33 ppmv), respectively (Hellman and Small, 1974).

출처

Reported found in apple, pear, grape, pineapple, strawberry, raspberry, tomato, black currant, citrus, onion and potato; also reported found in cocoa leaves, in Mexican goosefoot and in the oils of coriander and lavender. In trace amounts it has been reportedly identified in the oil of bitter orange, in distilled wine and in coffee aroma

역사

The traditional method of producing acetone in the 19th century and the beginning of the 20th century was to distill acetates, particularly calcium acetate, Ca(C2H3O2)2.
Weizmann discovered a process to produce butyl alcohol and acetone from the bacterium Clostridium acetobutylicum in 1914. With England’s urgent demand for acetone, Winston Churchill (1874–1965) enlisted Weizmann to develop the Weizmann process for acetone production on an industrial scale. Fermentation and distillation techniques for acetone production were replaced starting in the 1950s with the cumene oxidation process . In this process, cumene is oxidized to cumene hydroperoxide, which is then decomposed using acid to acetone and phenol. This is the primary method used to produce phenol, and acetone is produced as a co-product in the process, with a yield of about 0.6:1 of acetone to phenol.

용도

Acetone is used in the chemical industry in numerous applications. The primary use of acetone is to produce acetone cyanohydrin, which is then used in the production of methyl methacrylate (MMA). Another use of acetone in the chemical industry is for bisphenol A (BPA). BPA results form the condensation reaction of acetone and phenol in the presence of an appropriate catalyst. BPA is used in polycarbonate plastics, polyurethanes, and epoxy resins. Polycarbonate plastics are tough and durable and are often used as a glass substitute.
In addition to its use as a chemical feedstock and intermediate, acetone is used extensively as an organic solvent in lacquers, varnishes, pharmaceuticals, and cosmetics. Nail polish remover is one of the most common products containing acetone. Acetone is used to stabilize acetylene for transport .

용도

Acetone is used in the manufacture of a largenumber of compounds, such as acetic acid,chloroform, mesityl oxide, and MIBK; in themanufacture of rayon, photographic films,and explosives; as a common solvent; inpaint and varnish removers; and for purifyingparaffins.

용도

Acetone′s luminesence intensity is dependent upon the solution components 1. The absorption of UV light by acetone, results in its photolysis and the production of radials 1.

용도

Solvent for fats, oils, waxes, resins, rubber, plastics, lacquers, varnishes, rubber cements. manufacture of methyl isobutyl ketone, mesityl oxide, acetic acid (ketene process), diacetone alcohol, chloroform, iodoform, bromoform, explosives, aeroplane dopes, rayon, photographic films, isoprene; storing acetylene gas (takes up about 24 times its vol of the gas); extraction of various principles from animal and plant substances; in paint and varnish removers; purifying paraffin; hardening and dehydrating tissues. Pharmaceutic aid (solvent).

용도

acetone is a solvent considered to be non-comedogenic and occasionally used in skin toners. It is primarily used in nail polish remover. It could be drying and very irritating to the skin depending on the concentration and frequency of use.

정의

ChEBI: A methyl ketone that consists of propane bearing an oxo group at C2.

생산 방법

Acetone can also be produced from isopropanol using several methods, but the main methodis by catalytic dehydrogenation.

생산 방법

Acetone is obtained by fermentation as a by-product of n-butyl alcohol manufacture, or by chemical synthesis from isopropyl alcohol; from cumene as a by-product in phenol manufacture; or from propane as a by-product of oxidation-cracking.

화학 반응

Acetone reacts with many chemicals in a marked manner: (1) with phosphorus pentachloride, yields acetone chloride (CH3)2CCl2, (2) with hydrogen chloride dry, yields both mesityl oxide CH3COCH:C(CH3)2, liquid, bp 132 °C, and phorone (CH3)2C:CHCOCH : C(CH3)2, yellow solid, mp 28 °C, (3) with concentrated H2SO4, yields mesitylene C6H3(CH3)3 (1,3,5), (4) with NH3, yields acetone amines, e.g., diacetoneamine C6H12ONH, (5) with HCN, yields acetone cyanohydrin (CH3)2CHOH·CN, readily converted into alpha-hydroxy acid (CH3)2CHOH·COOH, (6) with sodium hydrogen sulfite, forms acetonesodiumbisulfite (CH3)2 COH·SO3Na white solid, from which acetone is readily recoverable by treatment with sodium carbonate solution, with hydroxylamine hydrochloride, forms acetoxime (CH3)2C:NOH, solid, mp 60 °C, with phenylhydrazine, yields acetonephenyl-hydrazone (CH3)2C:NNHC6H5·H2O, solid,mp 16 °C, anhydrous compound,mp42 °C, (9)with semicarbazide, forms acetonesemicarbazone (CH3)C:NNHCONH2, solid, mp 189 °C, with magnesium methyl iodide in anhydrous ether (“Grignard’s solution”), yields, after reaction with H2O, trimethylcarbinol (CH3)3COH, a tertiary alcohol, with ethyl thioalcohol and hydrogen chloride dry, yields mercaptol (CH3)2C(SC2H5)2, with hypochlorite, hypobromite, or hypoiodite solution, yields chloroform CHCl3, bromoform CHBr3 or iodoformCHI3, respectively, (13)with mostreducing agents, forms isopropyl alcohol (CH3)2CHOH, a secondary alcohol, but with sodium amalgam forms pinacone (CH3)2COH·COH(CH3)2 with sodium dichromate and H2SO4, forms acetic acid CH3COOH plus CO2. When acetone vapor is passed through a tube at a dull red heat, ketene CH2:CO and methane CH4 are formed.

Aroma threshold values

Detection: 40 to 476 ppm

일반 설명

A clear colorless liquid with a sweetish odor. Flash point 0°F. Less dense than water. Vapors are heavier than air. Used as a solvent in paint and nail polish removers.

공기와 물의 반응

Highly flammable. Water soluble.

반응 프로필

Acetone was reported that a mixture of Acetone and chloroform, in a residue bottle, exploded. Since addition of Acetone to chloroform in the presence of base will result in a highly exothermic reaction, Acetone is thought that a base was in the bottle [MCA Case History 1661. 1970]. Also, Nitrosyl chloride, sealed in a tube with a residue of Acetone in the presence of platinum catalyst, gave an explosive reaction [Chem. Eng. News 35(43):60. 1967]. The reaction of nitrosyl perchlorate and Acetone ignites and explodes. Explosions occur with mixtures of nitrosyl perchlorate and primary amine [Ann. Chem. 42:2031. 1909]. Reacts violently with nitric acid. Also causes exothermic reaction when in contact with aldehydes.

건강위험

The acute toxicity of acetone is low. Acetone is primarily a central nervous system depressant at high concentrations (greater than 12,000 ppm). Unacclimated volunteers exposed to 500 ppm acetone experienced eye and nasal irritation, but it has been reported that 1000 ppm for an 8-hour day produced no effects other than slight transient irritation to eyes, nose, and throat. Therefore there are good warning properties for those unaccustomed to working with acetone; however, frequent use of acetone seems to cause accommodation to its slight irritating properties. Acetone is practically nontoxic by ingestion. A case of a man swallowing 200 mL of acetone resulted in his becoming stuporous after 1 hour and then comatose; he regained consciousness 12 hour later. Acetone is slightly irritating to the skin, and prolonged contact may cause dermatitis. Liquid acetone produces moderate transient eye irritation. Acetone has not been found to be carcinogenic in animal tests or to have effects on reproduction or fertility.

화재위험

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

인화성 및 폭발성

Acetone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Acetone vapor forms explosive mixtures with air at concentrations of 2 to 13% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acetone fires.

Pharmaceutical Applications

Acetone is used as a solvent or cosolvent in topical preparations, and as an aid in wet granulation.It has also been used when formulating tablets with water-sensitive active ingredients, or to solvate poorly water-soluble binders in a wet granulation process. Acetone has also been used in the formulation of microspheres to enhance drug release.Owing to its low boiling point, acetone has been used to extract thermolabile substances from crude drugs.

공업 용도

Acetone is valuable solvent component in acrylic/nitrocellulose automotive lacquers. Acetone is the solvent of choice in film coatings operations which use vinylidene chloride-acrylonitrile copolymer formulations.Other ketones that may be used in these film coating operations include methyl isobutyl ketone, ethyl n-amyl ketone, and diisobutyl ketone.Acetone, blends of MIBK and MEK, methyl namyl ketone, ethyl n-amyl ketone, and diisobutyl ketone are all useful solvents for vinyl resin copolymers. The presence of one of the slower evaporating ketones in the solvent blend prevents quick drying, improves flow, and gives blush resistance to the coating. Acetone is also used as a resin thinner in polyester resins and as a clean up solvent for the resin reactor kettle.In solvents industry, Acetone is a component of solvent blends in urethane, nitrile rubber, and neoprene industrial adhesives.Acetone is the primary solvent in resin-type adhesives and pressure sensitive chlorinated rubber adhesives. Acetone also can be used to extract fats, oils, waxes, and resins from natural products, to dewax lubricating oils, and to extract certain essential oils.Acetone is also an important chemical intermediate in the preparation of several oxygenated solvents including the ketones, diacetone alcohol, mesityl oxide, methyl isobutyl ketone, and isophorone.

Safety Profile

Moderately toxic by various routes. A skin and severe eye irritant. Human systemic effects by inhalation: changes in EEG, changes in carbohydrate metabolism, nasal effects, conjunctiva irritation, respiratory system effects, nausea and vomiting, and muscle weakness. Human systemic effects by ingestion: coma, kidney damage, and metabolic changes. Narcotic in high concentration. In industry, no injurious effects have been reported other than skin irritation resulting from its defatting action, or headache from prolonged inhalation. Experimental reproductive effects. A common air contaminant. Highly flammable liquid. Dangerous disaster hazard due to fire and explosion hazard; can react vigorously with oxidizing materials. Potentially explosive reaction with nitric acid + sulfuric acid, bromine trifluoride, nitrosyl chloride + platinum, nitrosyl perchlorate, chromyl chloride, thiotrithiazyl perchlorate, and (2,4,6-trichloro-l,3,5triazine + water). Reacts to form explosive peroxide products with 2-methyl-1,3butadiene, hydrogen peroxide, and peroxomonosulfuric acid. Ignites on contact with activated carbon, chromium trioxide, dioxygen difluoride + carbon dioxide, and potassium-tert-butoxide. Reacts violently with bromoform, chloroform + alkalies, bromine, and sulfur dichloride. Incompatible with CrO, (nitric + acetic acid), NOCl, nitryl perchlorate, permonosulfuric acid, NaOBr, (sulfuric acid + potassium dichromate), (tho-diglycol + hydrogen peroxide), trichloromelamine, air, HNO3, chloroform, and H2SO4. To fight fire, use Con, dry chemical, alcohol foam. Used in production of drugs of abuse

Safety

Acetone is considered moderately toxic, and is a skin irritant and severe eye irritant. Skin irritation has been reported due to its defatting action, and prolonged inhalation may result in headaches. Inhalation of acetone can produce systemic effects such as conjunctival irritation, respiratory system effects, nausea, and vomiting.
LD50 (mouse, oral): 3.0 g/kg
LD50 (mouse, IP): 1.297 g/kg
LD50 (rabbit, oral): 5.340 g/kg
LD50 (rabbit, skin): 0.2 g/kg
LD50 (rat, IV): 5.5 g/kg
LD50 (rat, oral): 5.8 g/kg

Chemical Synthesis

By fermentation, or by chemical synthesis from isopropanol, cumene or propane

잠재적 노출

It is used as a solvent in nail polish remover and many other chemicals. Used in the production of lubricating oils and as an intermediate in the manufacture of chloroform and of various pharmaceuticals and pesticides.

Source

Naturally occurs in blood and urine in small concentrations. Reported in cigarette smoke (1,100 ppm) and gasoline exhaust (2.3 to 14.0 ppm) (quoted, Verschueren, 1983).
Acetone occurs naturally in many plant species including cuneate Turkish savory (Satureja cuneifolia), catmint (Nepeta racemosa), Guveyoto (Origanum sipyleum), and Topukcayi shoots (Micromeria myrtifolia) at concentrations of 20, 2, 2, and 0.1, respectively (Baser et al., 1992, 1993; Ozek et al., 1992; Tumen, 1991). Acetone was also detected in Turkish calamint (Calamintha nepeta ssp. glandulosa) (Kirimer et al., 1992), pineapples, cauliflower leaves, tea leaves, West Indian lemongrass, jimsonweed, soybeans, carrots, bay leaves, hop flowers, apples, tomatoes, water mint leaves, alfalfa, pears, rice plants, white mulberries, clover-pepper, and roses (Duke, 1992). Acetone also was emitted from many forest plant species (Isidorov et al., 1985).
Acetone was detected in diesel fuel at a concentration of 22,000 μg/g (Schauer et al., 1999). Identified as an oxidative degradation product in the headspace of a used engine oil (10–30W) after 4,080 miles (Levermore et al., 2001). Acetone also was detected in automobile exhaust at concentrations ranging from 0.09 to 4.50 mg/m3 (Grimaldi et al., 1996) and in cigarette smoke at concentrations ranging from 498 to 869 mg/m3 (Euler et al., 1996).
Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered automobiles with and without catalytic converters were 1.19 and 42 mg/km, respectively (Schauer et al., 2002).
Vereecken and Peeters (2000) reported that acetone is formed from the reaction of α-pinene and OH radicals in the atmosphere. This reaction resulted in an acetone yield of 8.5% which is consistent with available experimental data.
Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of acetone were 749 mg/kg of pine burned, 462 mg/kg of oak burned, and 79 mg/kg of eucalyptus burned.

환경귀착

Biological. Following a lag time of 20 to 25 h, acetone degraded in activated sludge (30 mg/L) at a rate constant ranging from 0.016 to 0.020/h (Urano and Kato, 1986). Soil bacteria can mineralize acetone to carbon dioxide (Taylor et al., 1980). Bridié et al. (1979) reported BOD and COD values of 1.85 and 1.92 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. Similarly, Heukelekian and Rand (1955) reported a 5-d BOD value of 0.85 g/g which is 38.5% of the ThOD value of 2.52 g/g. Waggy et al. (1994) reported 5, 15, and 28-d BOD values of 14, 74, and 74%, respectively. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM acetone) and ThOD were 1.52 and 38.0%, respectively (Vaishnav et al., 1987).
Photolytic. Photolysis of acetone in air yields carbon monoxide and free radicals, but in isopropanol, pinacol is formed (Calvert and Pitts, 1966). Photolysis of acetone vapor with nitrogen dioxide via a mercury lamp gave peroxyacetyl nitrate as the major product with smaller quantities of methyl nitrate (Warneck and Zerbach, 1992).
Chemical/Physical. Hypochlorite ions, formed by the chlorination of water for disinfection purposes, may react with acetone to form chloroform. This reaction is expected to be significant within the pH range of 6 to 7 (Stevens et al., 1976).

저장

Acetone should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

운송 방법

UN1090 Acetone, Hazard Class: 3; Labels: 3-Flammable liquid

Purification Methods

The commercial preparation of acetone by catalytic dehydrogenation of isopropyl alcohol gives relatively pure material. Analytical reagent quality generally contains less than 1% of organic impurities but may have up to about 1% of H2O. Dry acetone is appreciably hygroscopic. The main organic impurity in acetone is mesityl oxide, formed by aldol condensation. It can be dried with anhydrous CaSO4, K2CO3 or type 4A Linde molecular sieves, and then distilled. Silica gel and alumina, or mildly acidic or basic desiccants cause acetone to undergo the aldol condensation, so that its water content is increased by passage through these reagents. This also occurs to some extent when P2O5 or sodium amalgam is used. Anhydrous MgSO4 is an inefficient drying agent, and CaCl2 forms an addition compound. Drierite (anhydrous CaSO4) offers minimum acid and base catalysis for aldol formation and is the recommended drying agent for this solvent [Coetzee & Siao Inorg Chem 14 2 1987, Riddick & Bunger Organic Solvents Wiley-Interscience, N.Y., 3rd edn, 1970]. Acetone can be shaken with Drierite (25g/L) for several hours before it is decanted and distilled from fresh Drierite (10g/L) through an efficient column, maintaining atmospheric contact through a Drierite drying tube. The equilibrium water content is about 10-2M. Anhydrous Mg(ClO4)2 should not be used as drying agent because of the risk of EXPLOSION with acetone vapour. Organic impurities have been removed from acetone by adding 4g of AgNO3 in 30mL of water to 1L of acetone, followed by 10mL of M NaOH, shaking for 10minutes, filtering, drying with anhydrous CaSO4 and distilling [Werner Analyst (London) 58 335 1933]. Alternatively, successive small portions of KMnO4 have been added to acetone at reflux, until the violet colour persists, followed by drying and distilling. Refluxing with chromium trioxide (CrO3) has also been used. Methanol has been removed from acetone by azeotropic distillation (at 35o) with methyl bromide, and treatment with acetyl chloride. Small amounts of acetone can be purified as the NaI addition compound, by dissolving 100g of finely powdered NaI in 400g of boiling acetone, then cooling in ice and salt to -8o. Crystals of NaI.3Me2CO are filtered off and, on warming in a flask, acetone distils off readily. [This method is more convenient than the one using the bisulfite addition compound.] It has also been purified by gas chromatography on a 20% free fatty acid phthalate (on Chromosorb P) column at 100o. For efficiency of desiccants in drying acetone see Burfield and Smithers [J Org Chem 43 3966 1978]. The water content of acetone can be determined by a modified Karl Fischer titration [Koupparis & Malmstadt Anal Chem 54 1914 1982]. [Beilstein 1 IV 3180.] Rapid procedure: Dry over anhydrous CaSO4 and distil.

비 호환성

Acetone reacts violently with oxidizing agents, chlorinated solvents, and alkali mixtures. It reacts vigorously with sulfur dichloride, potassium t-butoxide, and hexachloromelamine. Acetone should not be used as a solvent for iodine, as it forms a volatile compound that is extremely irritating to the eyes.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.

Regulatory Status

Included in the FDA Inactive Ingredients Database (inhalation solution; oral tablets; topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

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