Levamisole hydrochloride
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Levamisole hydrochloride 속성
- 녹는점
- 266-267 °C(lit.)
- 알파
- -128 º (c=5, H2O)
- 굴절률
- -126 ° (C=1, H2O)
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- 물에 잘 녹고, 에탄올(96%)에 녹고, 염화메틸렌에는 약간 녹습니다.
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 거의 흰색
- 수용성
- 210g/L(20℃)
- Merck
- 14,5459
- BRN
- 4358988
- BCS Class
- 3/1
- 안정성
- 흡습성
- InChI
- InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/s3
- InChIKey
- LAZPBGZRMVRFKY-HNCPQSOCSA-N
- SMILES
- [C@H]1(N=C2SCCN2C1)C1=CC=CC=C1.Cl |&1:0,r|
- LogP
- 1.845 (est)
- CAS 데이터베이스
- 16595-80-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xn,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-20/21/22-39/23/24/25-23/24/25-11 | ||
| 안전지침서 | 36/37/39-45-28A-36-36/37-16 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NJ5960000 | ||
| F 고인화성물질 | 10 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29349990 | ||
| 기존화학 물질 | KE-33497 |
Levamisole hydrochloride C화학적 특성, 용도, 생산
화학적 성질
White to light yellow crystalline powder, odorless, bitter taste. Melting point 227-229℃. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform and aether; insoluble in acetone. Stable under acidic conditions, but easy to decompose and fail under alkaline conditions.용도
Levamisole hydrochloride is an anthelmintic. The activity of levamisole is about twice as high as that of abscisicidal, and the toxicity and side effects are lower. Levamisole can cause muscle paralysis of roundworms and then excrete them in the feces. It is mainly used as an anti-worm and anti-hookworm.용도
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.제조 방법
Levamisole hydrochloride was prepared from racemic tetraimidazole by splitting, alkali analysis and acidification into salt.Dibenzoyl-D-tartaric acid is boiled in water for 40min, hydrolyzed and neutralized with sodium hydroxide solution to pH 7.5, and then added to racemic tetraimidazole. The levamisole is precipitated by generating salt with bisbenzoyl-tartaric acid. After separation, add sodium hydroxide solution to PH=9 and decompose levamisole. Then dissolved in dilute hydrochloric acid solution, after decolorization by activated carbon, the filtrate was concentrated nearly dry, and crystallized by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride.
Mode of action
Levamisole is a cholinergic receptor agonist and elicits spastic muscle paralysis due to prolonged activation of the excitatory nicotinic acetylcholine receptors (nAChR) on nematode body wall muscle.Toxicity evaluation
Symptoms of levamisole toxicity mimic organophosphate toxicity (salivation, lacrimation, urination and defecation, hyperesthesia, seizures and irritability). There is no antidote for levamisole toxicity.The World Health Organization reviewed hematological studies in animals and humans and derived acceptable daily intake for levamisole as 0.006 mg/kg body weight. This suggests a person can ingest 0.36 mg of levamisole/day over a lifetime without any appreciable risk.
levamisole
Levamisole hydrochloride 준비 용품 및 원자재
원자재
(1S)-(+)-Camphor-10-sulphonic acid
(+)-디벤조닐-D-주석산
레바미졸
물
DL-Tetramisole BP(V)98
Benzene
Dilute hydrochloric acid
주석산 염
수산화나트륨
염산
에틸렌 디브롬
수산화칼륨
준비 용품
Levamisole hydrochloride 공급 업체
글로벌( 663)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 |
info@longyupharma.com | China | 2531 | 58 |
| Lihe Pharm Technology（Wuhan）Co.,Ltd | +8618071517867 |
info@lihepharma.com | China | 194 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 |
admin@whrchem.com | China | 164 | 58 |
| Taiyuan CJ Trading Co., Ltd | +86-18536636121 |
anna@lianxuchemical.com | China | 8 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Levamisole hydrochloride 관련 검색:
벤조티아졸 2-메틸-4-이소티아졸린-3-온 레바미졸 하이드록시 트라이페닐주석 포스티아제이트 2-메르캅토벤조티아졸 이미다졸 2-멜캅토에틸아민 수화염화물 (R)-(+)-알파-메틸벤질아민
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