나린진
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나린진 속성
- 녹는점
- 166 °C
- 알파
- -91 º (c=1, C2H5OH)
- 끓는 점
- 559.35°C (rough estimate)
- 밀도
- 1.3285 (rough estimate)
- 증기압
- 2.25Pa at 20℃
- 굴절률
- -84 ° (C=2, EtOH)
- 저장 조건
- 2-8°C
- 용해도
- DMSO : 1 mg/mL (1.72 mM; Need ultrasonic)H2O : 1 mg/mL (1.72 mM; ultrasonic and warming and heat to 80°C)
- 물리적 상태
- 수정 같은
- 산도 계수 (pKa)
- 7.17±0.40(Predicted)
- 색상
- 회백색
- optical activity
- [α]20/D 80±10°, c = 1% in ethanol
- 수용성
- 물, 알코올, 아세톤 및 따뜻한 아세트산에 용해됩니다.
- Merck
- 14,6425
- BRN
- 102012
- LogP
- -0.44 at 20℃
- CAS 데이터베이스
- 10236-47-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38 | ||
안전지침서 | 22-24/25-36-26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QN6340000 | ||
F 고인화성물질 | 3 | ||
TSCA | Yes | ||
HS 번호 | 29389090 |
나린진 C화학적 특성, 용도, 생산
순도시험
(1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.
(3) 잔류용매 : 이 품목을 「파프리카추출색소」의 순도시험 (5)에 따라 시험할 때, 메탄올 50ppm 이하이어야 한다.
확인시험
(1) 이 품목 5mg에 50% 에탄올 10mL를 가하여 녹이고 염화제이철용액(1→500)을 1∼2방울을 가하였을 때 그 액은 갈색을 나타낸다.
(2) 이 품목 5mg에 수산화나트륨시액 5mL를 가하고 용해시켰을 때 그 액은 등황∼황색을 나타낸다.
(3) 이 품목 10mg에 물 500mL를 가하여 녹인 액은 파장 280∼285nm에서 극대흡수부가 있다.
정량법
이 품목을 105℃에 3시간 건조시킨 후 약 0.2g을 정밀히 달아 50% 에탄올에 녹인 후 정확히 100mL로 한다. 이 액을 0.45㎛ 필터에 여과시킨 후, 이 액 1mL을 정확히 취하여 물을 가하여 100mL로 한 것을 시험용액으로 사용한다. 물을 대조액으로 하여 280nm에서의 흡광도를 측정하여 다음 계산식에 따라 함량을 계산한다.
A : 시험용액의 흡광도
정의
이 품목은 운향과 귤(Citrus paradisi MACF.) 등의 과피, 과즙 또는 종자를 물 또는 상온의 에탄올 또는 메탄올로 추출하고 분리 정제하여 얻어지는 것으로서 그 성분은 나린진이다.
개요
Naringin is also called naringoside, hesperidin, and isohesperidin. It is a pale yellow flavanone compound extracted from immature or nearly mature outer layer of C. paradisi Macfad which belongs to Citrus grandis (L.) Osbeck. It tastes bitter and is naturally existed in the skin and flesh of Rutaceae like grapefruit, mandarin orange, and orange. It is also one of the active ingredients in many traditional Chinese medi cines like Rhizoma Drynariae, Immature Bitter Orange, Fructus Aurantii, and Exocarpium Citri Grandis. The contents of naringin in different plants vary greatly with the category and origin, and the content of naringin is high in immature fruits . In terms of traditional Chinese medicine, the flavor of grapefruit is sweet and sour, and the nature is cold; the flavors of its peel are sweet, pungent, and bitter, and the nature of its peel is warm. Both the pulp and the peel of grapefruit have the bio logical function including reducing phlegm, helping digestion, relieving abdominal distention, and fast diaphragm. And they are mainly used for the treatment of cough with asthma, sense of suppression in the chest, coldness and pain in abdomen, dys peptic retention, and hernia.화학적 성질
beige to yellowish powder물리적 성질
Appearance: white to light yellow crystalline powder. Solubility: soluble in metha nol, ethanol, acetone, acetic acid, dilute alkali solution, and hot water and insoluble in nonpolar solvent like petroleum benzin, ether, benzene, and chloroform. Melting역사
Naringin is mainly existed in the peel of grapefruit, lime, and their varieties; it has multiple biological activities and is widely applied in the fields of medicine, food, and cosmetics. In the 1930s, Harvey and Rygg obtained naringin through the method of isolation and extraction. They also established a colorimetric method for the determination of naringin, which laid the foundation for the following researches . Booth and other researchers conducted the systematic researches on the narin gin metabolites . In the 1960s, Hagen and other researchers established a fluores cence chromatography method for the determination naringin . In addition, the biological activity of naringin was evaluated. It was observed to improve ascites, experimental pulmonary edema, peritonitis, and oxygenation . At present, the extraction methods of naringin are hot water extraction, alkali extraction, and acid precipitation and organic solvent extraction. A series of pharmacological activity studies have been conducted and demonstrated its various biological activities .용도
Naringoside is a metabolite of Naringin (N378980), a major flavonoid found in grapefruit juice. It has antioxidant, lipid lowering, and anticancer activities. It is also an inhibitor of cytochrome P450 enzymes, affecting drug metabolism and thus drug absorption in humans.정의
ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosi ic linkage.일반 설명
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KGClinical Use
It was used for the treatment of bacterial infection, calm, and cancer preventionPurification Methods
This bitter principle from grape juice crystallises from water to give the hydrate with 6-8 H2O which when dried at 110o gives the dihydrate. Its solubility in H2O is 0.1% at 40o and 10% at 75o. The 2,4-dinitrophenylhydrazone crystallises from aqueous dioxane with m 246-247o [Douglass et al. J Am Chem Soc 73 4023 1951]. [Pulley & von Loesecke J Am Chem Soc 61 175 1939, Beilstein 18 III/IV 2637, 18 V 528.]나린진 준비 용품 및 원자재
원자재
준비 용품
나린진 공급 업체
글로벌( 600)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jiurui Biology Chemistry Co.,Ltd. | +86-0744-8561603 +8619974416182 |
sales11@jiuruibiochem.com | China | 26 | 58 |
Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 |
info@staherb.cn | China | 1025 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 |
gao490372054@gamil.com | China | 1250 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2990 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12465 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
BINBO BIOLOGICAL CO.,LTD | +8618629063126 |
info@binbobiological.com | China | 346 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
나린진 관련 검색:
살리신 메틸헤스페리딘 비타민 P
Naringenin
Naringin dihydrochalcone
Hesperetin
Icariin
Naringenin 7-O-β-D-Glucuronide
(Mixture of Diastereomers)
(+/-)-Naringenin
NARINGENIN CHALCONE
Naringenin trimethyl ether
NARINGENIN
Naringin D4
4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-METHOXY-
7-METHOXYFLAVANONE
Phloretin
NARIRUTIN
Neosperidin dihydrochalcone