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덱스트란

덱스트란
덱스트란 구조식 이미지
카스 번호:
9004-54-0
한글명:
덱스트란
동의어(한글):
덱스트란;알파-글루칸
상품명:
Dextran
동의어(영문):
LMD;LVD;LMWD;PL 1S;Hyskon;Hyscon;LU 122;MUCROSE;Onkotin;DEX 500
CBNumber:
CB8670298
분자식:
C17H32O10
포뮬러 무게:
396.42998
MOL 파일:
9004-54-0.mol

덱스트란 속성

녹는점
483 °C (decomp)
알파
198 º
굴절률
185 ° (C=6, H2O)
저장 조건
2-8°C
용해도
H2O: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow
물리적 상태
Solid
색상
White to slightly off-white
수소이온지수(pH)
2 - 10
수용성
Soluble in water, dimethyl sulfoxide, ethylene glycol and glycerol.
Merck
14,2948
안정성
Stable. Keep dry. Incompatible with strong oxidizing agents.
EPA
Dextran (9004-54-0)

안전

위험품 표기 Xn,Xi
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 24/25-37/39-36-26
WGK 독일 2
RTECS 번호 HH9230000
F 고인화성물질 3
TSCA Yes
HS 번호 39139000
독성 LD50 oral in rat: > 3gm/kg
기존화학 물질 KE-09622

덱스트란 MSDS


Dextran

덱스트란 C화학적 특성, 용도, 생산

개요

Dextrans are glucose polymers produced by bacteria linked in an α-1,6 chain and having an α-1,3 or α-1,4 branch about every fifth residue. The specific positioning of the branching varies by the bacterium producing it. The molecular weights of these chains generally are 40 or 70 kDa (dextran-40 and dextran-70, respectively), and the compounds work via an osmotic gradient similar to the colloids and hypertonic crystalloid solutions.
Dextrans have a longer intravascular residence time than albumin, which limits interstitial edema. As with the crystalloids and other colloids, the dextrans have no oxygen-carrying capacity. Furthermore, because they are bacterial products, the dextrans have the potential to be potent antigens and induce anaphylaxis.

화학적 성질

white crystals or powder

Originator

LMD 10%,Abbott,US,1967

용도

Dextran is a polysaccharide composed of glucose molecules used as an antithrombotic to reduce blood viscosity and as a volume expander in anemia. Studies show that it inhibits the mannose receptor-med iated clearance of tissue-type plasminogen activator (t-PA).

용도

also available in pharma grade

용도

exhibit borad spectrum of biological activities, with very low anticoagulant capacity: they activate lipoprotein elimination by lipase stimulation, inhibit cell proliferation in vascular wall, regulate transport of plasmatic proteins and inhibit depositi

용도

antiinflammatory veterinary drug

용도

dextran is a polysaccharide with water-binding properties. It is also used to control product viscosity. Some studies indicate a capacity to enhance the anti-aging activity of formulations containing weak acids, as well as to reduce possible skin irritation arising from such acids.

정의

dextran: A glutinous glucose polymerproduced by certain bacteria. Itcan be made by fermenting sucrose(cane sugar) and is used as a thickeningagent, as a stabilizer in ice cream,and as a substitute for plasma inblood transfusions. Esters with sulphuricacid yield sodium salts thatare employed as anticoagulant drugs.

Manufacturing Process

Sucrose is subjected to the action of the bacterium Leuconosfoc mesenteroides B 512 and the crude, high-molecular weight dextran thus formed is hydrolyzed and fractionated to an average molecular weight of about 40,000 as measured by light-scattering techniques.

상표명

Gentran 40 (Baxter Healthcare).

Therapeutic Function

Plasma extender

Mechanism of action

Safety Profile

Suspected carcinogen with experimental carcinogenic data. When heated to decomposition it emits acrid smoke and fumes. See also other DEXTRANS.

Veterinary Drugs and Treatments

Dextran 70 is a relatively low cost colloid for the adjunctive treatment of hypovolemic shock. Hetastarch is the more commonly employed synthetic colloid used today.

Purification Methods

Solutions of dextran keep indefinitely at room temperature if 0.2mL of Roccal (10% alkyldimethylbenzylammonium chloride) or 2mg phenyl mercuric acetate are added per 100mL solution. This inhibits mould growth. [Scott & Melvin Anal Biochem 25 1656 1953.]

덱스트란 준비 용품 및 원자재

원자재

준비 용품


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