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PROTAMINE

PROTAMINE 구조식 이미지
카스 번호:
9012-00-4
상품명:
PROTAMINE
동의어(영문):
HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv
CBNumber:
CB9468351
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

PROTAMINE 속성

저장 조건
-20°C
용해도
H2O: clear

안전

WGK 독일 3
RTECS 번호 UK9440000
유해 물질 데이터 9012-00-4(Hazardous Substances Data)

PROTAMINE C화학적 특성, 용도, 생산

화학적 성질

Water soluble, producing basic solu- tions.

정의

protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.

정의

Simplest proteins, without sulfur, molecular weights about ~3000.

Mechanism of action

Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).

부작용

Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.

PROTAMINE 준비 용품 및 원자재

원자재

준비 용품


PROTAMINE 공급 업체

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