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Protamine Produkt Beschreibung

PROTAMINE Struktur
9012-00-4
CAS-Nr.
9012-00-4
Bezeichnung:
Protamine
Englisch Name:
PROTAMINE
Synonyma:
HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv
CBNumber:
CB9468351
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Protamine Eigenschaften

storage temp. 
-20°C
Löslichkeit
H2O: clear

Sicherheit

WGK Germany  3
RTECS-Nr. UK9440000
Giftige Stoffe Daten 9012-00-4(Hazardous Substances Data)

Protamine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Water soluble, producing basic solu- tions.

Definition

protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.

Definition

Simplest proteins, without sulfur, molecular weights about ~3000.

Mechanism of action

Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).

Nebenwirkungen

Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.

Protamine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Protamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 36)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5429 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29989 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9483 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD. 86-029-85456576
86-029-85456576-808 daisy_wang@vip.163.com China 293 55
Wuhan Dahua Pharmaceutical Co., Ltd. 027-59262863 13277907145 QQ:3091977954
027-59420980 dh.luna@whdhwy.com China 4957 58
Hubei Jusheng Technology Co.,Ltd 18871490274 027-59599241-
027-59599241 1400878000@qq.com;1400868000@qq.com China 9841 58
Sigma-Aldrich 800-8193336 021-61415566-
orderCN@merckgroup.com;orderCN@merckgroup.com China 48786 80
Wuhan Runzeweiye Technology Co., Ltd. 15172337137
027-50779735 runzeweiye999@163.com; China 804 55

9012-00-4(Protamine)Verwandte Suche:


  • protamines
  • PROTAMINE
  • protamine free base grade iv
  • protamine from salmon
  • HSDB 3251
  • PROTAMINE USP/EP/BP
  • 9012-00-4
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