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(S)-1-N-Boc-2-methylpiperazine

(S)-1-N-Boc-2-methylpiperazine 구조식 이미지

카스 번호:: 169447-70-5

상품명:: (S)-1-N-Boc-2-methylpiperazine

동의어(영문):: tert-butyl (S)-2-methylpiperazine-1-carboxylate;(R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-1-Boc-2-methl-piperazine;(S)-N-Boc-2-methylpiperazine;(R)-2-METHYL-1-BOC-PIPERAZINE;(S)-1-Boc-2-methyl-piperazine;(S)-N1-BOC-2-METHYLPIPERAZINE;1-Boc-2-(S)-Methyl Piperazine;(S)-1-N-BOC-2-METHYL PIPERAZINE

CBNumber:: CB9714476

분자식:: C10H20N2O2

포뮬러 무게:: 200.28

MOL 파일:: 169447-70-5.mol

속성

안전

용도

공급 업체 254

(S)-1-N-Boc-2-methylpiperazine 속성

녹는점: 43.0 to 47.0 °C

끓는 점: 268.7±15.0 °C(Predicted)

밀도: 0.997±0.06 g/cm3(Predicted)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: 메탄올에 용해됨

물리적 상태: powder to crystal

산도 계수 (pKa): 8.49±0.40(Predicted)

색상: 흰색에서 거의 흰색

InChI: InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1

InChIKey: DATRVIMZZZVHMP-QMMMGPOBSA-N

SMILES: N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C

CAS 데이터베이스: 169447-70-5(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

유엔번호(UN No.)	UN3077
HS 번호	2933599590

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H314	피부에 심한 화상과 눈에 손상을 일으킴	피부부식성 또는 자극성물질	구분 1A, B, C	위험		P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501

예방조치문구:

P260	분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.

(S)-1-N-Boc-2-methylpiperazine C화학적 특성, 용도, 생산

용도

(S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Synthesis

A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification.

(S)-1-N-Boc-2-methylpiperazine 준비 용품 및 원자재

원자재

(S)-1-BENZYL-3-METHYLPIPERAZINE-2,5-DIONE (S)-TERT-BUTYL 4-BENZYL-2-METHYLPIPERAZINE-1-CARBOXYLATE (S)-METHYL 2-(2-CHLOROACETAMIDO) PROPANOATE 2-(S)-METHYLPIPERAZINE-1,4-DICARBOXYLIC ACID 4-BENZYL ESTER 1-TER-BUTYL ESTER (S)-(+)-2-Methylpiperazine (S)-2-METHYL-4-BENZYLPIPERAZINE

준비 용품

FVQORRADVAYZAV-AWEZNQCLSA-N

(S)-1-N-Boc-2-methylpiperazine 공급 업체

글로벌( 254)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Purest Pharmaceuticl （Xi’an) Co,.LTD	+8613893405577	12829054@qq.com	China	74	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	724	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58

(S)-1-N-Boc-2-methylpiperazine 관련 검색:

t-부틸 퍼옥시벤조에이트 N-메틸피페라진 N-메틸-2-피롤리디논 N-메틸올아크릴아마이드 디이소뷰틸 프탈산 뷰틸파라벤 1-메틸이미다졸 N-메틸다이에탄올아민 N-메틸아세트아마이드 클로로탄산 이소부틸에스테르 (S)-1-Boc-2-isopropylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 2-Methylpiperazine 1-BENZHYDRYLPIPERAZINE (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER D-1-N-Boc-prolinamide (S)-(+)-N-TBOC-2-METHYLPIPERIDINE (S)-tert-butyl 4-aMinoazepane-1-carboxylate