Chlortetracycline hydrochloride
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Chlortetracycline hydrochloride 속성
- 녹는점
- 210-215 °C (dec.)(lit.)
- 알파
- D23 -240°
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 용해도
- 1M NaOH: 용해성50mg/mL
- 물리적 상태
- 가루
- 색상
- 희미한 노란색에서 노란색까지
- 산도 계수 (pKa)
- 3.3(at 25℃)
- 수용성
- 물에 용해됨
- 감도
- Light Sensitive
- Merck
- 13,2211
- BRN
- 3858364
- CAS 데이터베이스
- 64-72-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | QI7800000 | ||
위험 등급 | 3 | ||
HS 번호 | 29413020 | ||
독성 | LD50 orally in rats: 10300 mg/kg (Goldenthal) |
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Chlortetracycline hydrochloride MSDS
[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
Chlortetracycline hydrochloride C화학적 특성, 용도, 생산
개요
Chlortetracycline was found in the culture broth of Streptomyces aureofaciens by Duggar et al. of Lederle Laboratories in 1948 and named aureomycin. It shows a wider range of antibiotic activity than the earlier antibiotics, penicillins, and streptomycins and as great as that of chloramphenicol. Its activity covers grampositive and gram-negative bacteria as well as Rickettsia and Chlamydiae. Chlortetracycline has been replaced by other tetracyclines in clinical use and is used now used as a feed additive to promote the growth of livestock.화학적 성질
Yellow Solid용도
Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.일반 설명
Chlortetracycline (Aureomycin hydrochloride) was isolatedby Duggar in 1948 from S. aureofaciens. This compound,which was produced in an extensive search for new antibiotics,was the first of the group of highly successful tetracyclines.It soon became established as a valuable antibioticwith broad-spectrum activities.It is used in medicine chiefly as the acid salt of the compoundwhose systematic chemical designation is 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.The hydrochloride salt is a crystallinepowder with a bright yellow color, which suggested itsbrand name, Aureomycin. It is stable in air but slightly photosensitiveand should be protected from light. It is odorlessand bitter. One gram of the hydrochloride salt will dissolvein about 75 mL of water, producing a pH of about 3. It isonly slightly soluble in alcohol and practically insoluble inother organic solvents.
Oral and parenteral forms of chlortetracycline are nolonger used because of the poor bioavailability and inferiorpharmacokinetic properties of the drug. It is still marketed inointment forms for topical and ophthalmic use.
Purification Methods
Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]Chlortetracycline hydrochloride 준비 용품 및 원자재
원자재
준비 용품
Chlortetracycline hydrochloride 공급 업체
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Apeloa production Co.,Limited | +8619933239880 |
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Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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career henan chemical co | +86-0371-86658258 +8613203830695 |
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SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |