PROMETHAZINE
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PROMETHAZINE 속성
- 녹는점
- 60℃
- 끓는 점
- bp3 190-192°
- 밀도
- 1.131
- 굴절률
- 1.6000 (estimate)
- 저장 조건
- -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨, 초음파처리)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 9.1(H2O,t undefined) (Uncertain)
- 색상
- 페일베이지부터 페일브라운까지
- 수용성
- 383.9ug/L(22.5ºC)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유해 물질 데이터 | 60-87-7(Hazardous Substances Data) | ||
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독성 | LD50 oral in rabbit: 580mg/kg | ||
기존화학 물질 | KE-34662 |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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PROMETHAZINE C화학적 특성, 용도, 생산
개요
As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.용도
Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.정의
ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.World Health Organization (WHO)
Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.일반 설명
Crystals. Melting point 60°C. Used as an antihistaminic.공기와 물의 반응
Turns blue on prolonged exposure to air and moisture.반응 프로필
PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.건강위험
SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.화재위험
Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.Clinical Use
Promethazine, an early agent in the series, has many useful pharmacological affects other than being an antihistamine. It has significant antiemetic and anticholinergic properties. It also has sedative-hypnotic properties and has been used to potentiate the effects of analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as antipruritic agents in the treatment of urticaria.Safety Profile
Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOxPROMETHAZINE 준비 용품 및 원자재
원자재
준비 용품
PROMETHAZINE 공급 업체
글로벌( 91)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 |
admin@hblongbang.com | China | 942 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 992 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 7193 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8132 | 58 |
PROMETHAZINE 관련 검색:
페노티아진 페난트렌 프로메타진 수화염화물 페나세틴
1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride
rac N-Demethyl Promethazine Hydrochloride
ISOPROMETHAZINE HYDROCHLORIDE
PROMETHAZINE SULFOXIDE,Promethazine 5-Oxide,Promethazine 5-Sulfoxide
ISOTHIPENDYL
promethazine teoclate,Promethazine8-chlorotheophyllinate,Promethazine, 8-chlorotheophylline salt
ETHOPROPAZINE
aceprometazine
propiomazine
Promazine
Promethazine 5-Oxide-d6,Promethazine 5-Sulfoxide-d6,Promethazine Sulfoxide-d6
Promethazine for peak identification
(+/-)-Promethazine-d6 Hydrochloride,Promethazine-d6 Hydrochloride Salt
N-MONODESMETHYL PROMETHAZINE