BI 2536
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- $30 - $2841
- Product name: BI 2536
- CAS: 755038-02-9
- MF: C28H39N7O3
- MW: 521.65
- EINECS:1308068-626-2
- MDL Number:MFCD10565924
- Synonyms:BI-2536, BoehringerPLK-1 inhibitor;4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide;BI 2536;Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;Boehringer PLK-1 inhibitor;BI-2536(R-);BI2536/BI-2536;(R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
116 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- BLDpharm
- BroadPharm
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 200mg
- 500mg
- 0.5g
- 1000mg
- 5.00g
- 10.00g
- 10mM*1mLinDMSO
- 50.00g
- 1 unit
- 5 mg
- 25 mg
- 10mM(1mLinDMSO)
- 1mg
- EvaluationSample
- 5mg
- 10mg
- 20MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
- Packaging1mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
- Packaging5mg
- Price$43
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
- Packaging10mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
- Packaging25mg
- Price$121
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
- Packaging50mg
- Price$146
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
- Packaging100mg
- Price$262
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G2II
- Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
- Packaging250mg
- Price$507
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10293
- Product descriptionBI 2536 98%
- Packaging1G
- Price$1150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10293
- Product descriptionBI 2536 98%
- Packaging25MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10293
- Product descriptionBI 2536 98%
- Packaging100MG
- Price$350
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10293
- Product descriptionBI 2536 98%
- Packaging5MG
- Price$65
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M001
- Product description(R)-BI-2536 ≥95%
- Packaging1mg
- Price$86
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M005
- Product description(R)-BI-2536 ≥95%
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M005
- Product description(R)-BI-2536 ≥95%
- Packaging5mg
- Price$124
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M010
- Product description(R)-BI-2536 ≥95%
- Packaging10mg
- Price$211
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1019-M050
- Product description(R)-BI-2536 ≥95%
- Packaging50mg
- Price$702
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% | 1mg | $35 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% | 5mg | $43 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% | 10mg | $76 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide | 25mg | $121 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% | 50mg | $146 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% | 100mg | $262 | 2026-05-28 | Buy |
| aablocks | AA00G2II | (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% | 250mg | $507 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10293 | BI 2536 98% | 1G | $1150 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10293 | BI 2536 98% | 25MG | $145 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10293 | BI 2536 98% | 100MG | $350 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10293 | BI 2536 98% | 5MG | $65 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1019-M001 | (R)-BI-2536 ≥95% | 1mg | $86 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1019-M005 | (R)-BI-2536 ≥95% | 5mg | $124 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1019-M005 | (R)-BI-2536 ≥95% | 5mg | $124 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1019-M010 | (R)-BI-2536 ≥95% | 10mg | $211 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1019-M050 | (R)-BI-2536 ≥95% | 50mg | $702 | 2026-05-06 | Buy |
Properties
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES :C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES :C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI 2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM). It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI 2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice. It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells. BI 2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.More related product prices
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