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ChemicalBook >> CAS DataBase List >> Enasidenib

Enasidenib

$13 - $1450
Product name: Enasidenib
CAS: 1446502-11-9
MF: C19H17F6N7O
MW: 473.38
EINECS:
MDL Number:MFCD29472245
Synonyms:Enasidenib(AG-221);AG-221 (Enasidenib);AG-211;2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol;Enasidenib;AG-221;2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-;CS-1590

Price55 Properties Safety Information Description

55 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
TRC
Usbiological

Package

10mM*1mLinDMSO(Solution)
1mg
5mg
10mg
25mg
10mM*1mLinDMSO
50mg
100mg
10mM*1mLinDMSO(Solid+Solvent)
250mg
1g
5G

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%
Packaging5mg
Price$13
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%
Packaging10mg
Price$23
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%
Packaging25mg
Price$51
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%
Packaging50mg
Price$70
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%
Packaging100mg
Price$77
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%
Packaging250mg
Price$123
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001JUK
Product description2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%
Packaging1g
Price$435
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberL22067
Product descriptionEnasidenib 98%
Packaging1G
Price$350
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberL22067
Product descriptionEnasidenib 98%
Packaging5G
Price$1450
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberL22067
Product descriptionEnasidenib 98%
Packaging100MG
Price$75
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberL22067
Product descriptionEnasidenib 98%
Packaging25MG
Price$30
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number1996EB
Product descriptionEnasidenib
Packaging10mg
Price$212
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number1996EB
Product descriptionEnasidenib
Packaging50mg
Price$509
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0004694
Product descriptionENASIDENIB 95.00%
Packaging5MG
Price$498.27
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB7804
Product descriptionAG-221 (Enasidenib)
Packaging100mg
Price$198
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB7804
Product descriptionAG-221 (Enasidenib)
Packaging25mg
Price$121
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%	5mg	$13	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%	10mg	$23	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%	25mg	$51	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol ≥97%	50mg	$70	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%	100mg	$77	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%	250mg	$123	2026-05-28	Buy
aablocks	AA001JUK	2-Methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol 98%	1g	$435	2026-05-28	Buy
ACHEMBLOCK	L22067	Enasidenib 98%	1G	$350	2026-05-27	Buy
ACHEMBLOCK	L22067	Enasidenib 98%	5G	$1450	2026-05-27	Buy
ACHEMBLOCK	L22067	Enasidenib 98%	100MG	$75	2026-05-27	Buy
ACHEMBLOCK	L22067	Enasidenib 98%	25MG	$30	2026-05-27	Buy
AK Scientific	1996EB	Enasidenib	10mg	$212	2021-12-16	Buy
AK Scientific	1996EB	Enasidenib	50mg	$509	2021-12-16	Buy
American Custom Chemicals Corporation	INB0004694	ENASIDENIB 95.00%	5MG	$498.27	2021-12-16	Buy
ApexBio Technology	B7804	AG-221 (Enasidenib)	100mg	$198	2026-05-06	Buy
ApexBio Technology	B7804	AG-221 (Enasidenib)	25mg	$121	2026-05-06	Buy

Next Last

Properties

Melting point :168-170°C
Boiling point :581.0±60.0 °C(Predicted)
Density :1.477±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :14.70±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :DYLUUSLLRIQKOE-UHFFFAOYSA-N
SMILES :C(NC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC2C=CN=C(C(F)(F)F)C=2)=N1)C(C)(O)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Enasidenib (1446502-11-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.

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Suppliers and manufacturers

Shenzhen Yaoyuan R&D Center Co., Ltd Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Beijing HwrkChemical Technology Co., Ltd Nanjing Chemlin Chemical Co., Ltd Dalian Meilun Biotech Co., Ltd. Shanghai Hope Chem Co., Ltd.， Anhui nuoquan pharmaceutical co. LTD Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC

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Enasidenib

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