2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
![2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione price.](/CAS/20150408/GIF/1218942-37-0.gif)
|
- $32 - $1545
- Product name: 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
- CAS: 1218942-37-0
- MF: C21H19ClN4O2
- MW: 394.85
- EINECS:942-974-8
- MDL Number:MFCD27923122
- Synonyms:2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione;GKT137831;2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-5H-pyrazolo[4,3-c]pyridine-3,6-dione;2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione GKT137831;GKT137831, >=98%;2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-;CS-1795;GKT-137831;GKT 137831
23 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberX3563
- Product descriptionGKT137831
- Packaging10mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4763
- Product descriptionGKT137831
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4763
- Product descriptionGKT137831
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4763
- Product descriptionGKT137831
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3006
- Product descriptionGKT137831-Setanaxib|GKT831 99%
- Packaging2x25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137680
- Product descriptionGKT-137831
- Packaging250mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFG137680
- Product descriptionGKT-137831
- Packaging500mg
- Price$1125
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17764
- Product descriptionGKT137831 ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17764
- Product descriptionGKT137831 ≥95%
- Packaging5mg
- Price$74
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17764
- Product descriptionGKT137831 ≥95%
- Packaging10mg
- Price$124
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17764
- Product descriptionGKT137831 ≥95%
- Packaging25mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM118649
- Product description2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methylpyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 97%
- Packaging10mg
- Price$203
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3290
- Product descriptionSetanaxib 99.43%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3290
- Product descriptionSetanaxib 99.43%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3290
- Product descriptionSetanaxib 99.43%
- Packaging100mg
- Price$768
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3290
- Product descriptionSetanaxib 99.43%
- Packaging200mg
- Price$1140
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X3563 | GKT137831 | 10mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B4763 | GKT137831 | 5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B4763 | GKT137831 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | B4763 | GKT137831 | 50mg | $470 | 2021-12-16 | Buy |
| Axon Medchem | Axon3006 | GKT137831-Setanaxib|GKT831 99% | 2x25mg | $396 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137680 | GKT-137831 | 250mg | $625 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FG137680 | GKT-137831 | 500mg | $1125 | 2021-12-16 | Buy |
| Cayman Chemical | 17764 | GKT137831 ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17764 | GKT137831 ≥95% | 5mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 17764 | GKT137831 ≥95% | 10mg | $124 | 2024-03-01 | Buy |
| Cayman Chemical | 17764 | GKT137831 ≥95% | 25mg | $455 | 2021-12-16 | Buy |
| Chemenu | CM118649 | 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methylpyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 97% | 10mg | $203 | 2021-12-16 | Buy |
| ChemScene | CS-3290 | Setanaxib 99.43% | 5mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-3290 | Setanaxib 99.43% | 50mg | $540 | 2021-12-16 | Buy |
| ChemScene | CS-3290 | Setanaxib 99.43% | 100mg | $768 | 2021-12-16 | Buy |
| ChemScene | CS-3290 | Setanaxib 99.43% | 200mg | $1140 | 2021-12-16 | Buy |
Properties
Boiling point :560.5±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 65 mg/ml).
form :solid
pka :5.13±0.25(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 65 mg/ml).
form :solid
pka :5.13±0.25(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
NADPH oxidase 1 (NOX1) and NOX4 generate reactive oxygen species (ROS) that are critical in regulating a variety of cellular functions but also contribute to many diseases. GKT137831 is a dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production. It shows only weak inhibitory activity against NOX2 or xanthine oxidase and does not block neutrophil oxidative burst, scavenge ROS, or have antioxidant activity. GKT137831 displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice. It reduces hypoxia-induced pulmonary vascular cell proliferation, ameliorates dopaminergic neuronal death, and provides renoprotection in long-term diabetic nephropathy.Related product price
- 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide
$28-4644 - BI 2536
$37-2839 - Regorafenib
$25-1208.7