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ChemicalBook >> GF109203X

GF109203X

GF109203X price.
  • $53.6 - $706
  • Product name: GF109203X
  • CAS: 133052-90-1
  • MF: C25H24N4O2
  • MW: 412.48
  • EINECS:
  • MDL Number:MFCD00236428
  • Synonyms:InSolution Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem;GO 6850;GO 6850 HCL;GF 109203X;GF-109203X HCL;GF109203X HYDROCHLORIDE;BISINDOLYLMALEIMIDE;BISINDOLYLMALEIMIDE I
9 prices
Selected condition:

Brand

  • Alfa Aesar
  • Cayman Chemical
  • Sigma-Aldrich

Package

  • 250ug
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAlfa Aesar
  • Product numberJ63401
  • Product descriptionBisindolylmaleimide 1
  • Packaging5mg
  • Price$120
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63401
  • Product descriptionBisindolylmaleimide 1
  • Packaging25mg
  • Price$427
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number13298
  • Product descriptionBisindolylmaleimide I ≥95%
  • Packaging50mg
  • Price$552
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number13298
  • Product descriptionBisindolylmaleimide I ≥95%
  • Packaging25mg
  • Price$311
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number13298
  • Product descriptionBisindolylmaleimide I ≥95%
  • Packaging10mg
  • Price$131
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number13298
  • Product descriptionBisindolylmaleimide I ≥95%
  • Packaging5mg
  • Price$69
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number203290
  • Product descriptionBisindolylmaleimide I
  • Packaging250ug
  • Price$53.6
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number203290
  • Product descriptionBisindolylmaleimide I
  • Packaging1mg
  • Price$141
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberG2911
  • Product descriptionGF 109203X synthetic, ≥90% (HPLC)
  • Packaging1mg
  • Price$706
  • Updated2018-11-13
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J63401 Bisindolylmaleimide 1 5mg $120 2018-11-13 Buy
Alfa Aesar J63401 Bisindolylmaleimide 1 25mg $427 2018-11-13 Buy
Cayman Chemical 13298 Bisindolylmaleimide I ≥95% 50mg $552 2018-11-13 Buy
Cayman Chemical 13298 Bisindolylmaleimide I ≥95% 25mg $311 2018-11-13 Buy
Cayman Chemical 13298 Bisindolylmaleimide I ≥95% 10mg $131 2018-11-13 Buy
Cayman Chemical 13298 Bisindolylmaleimide I ≥95% 5mg $69 2018-11-13 Buy
Sigma-Aldrich 203290 Bisindolylmaleimide I 250ug $53.6 2018-11-20 Buy
Sigma-Aldrich 203290 Bisindolylmaleimide I 1mg $141 2018-11-20 Buy
Sigma-Aldrich G2911 GF 109203X synthetic, ≥90% (HPLC) 1mg $706 2018-11-13 Buy

Properties

Melting point: :280℃ (decomposition)
storage temp.  :2-8°C
solubility  :DMSO: ~1 mg/mlsoluble
form  :Liquid
Water Solubility  :Insoluble in water.

Safety Information

Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine. It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα-, β1-, β2-, γ-, δ-, and ε-isozymes. BIM I directly inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). This compound also competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM.

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