Lomitapide
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- $32 - $1500
- Product name: Lomitapide
- CAS: 182431-12-5
- MF: C39H37F6N3O2
- MW: 693.72
- EINECS:
- MDL Number:MFCD16620494
- Synonyms:N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide;AEGR 733;BMS 201038;BMS 201038-01;BMS 201238;LoMitapide;N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide
23 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chem-Impex
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberZ1876
- Product descriptionLomitapide
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberZ1876
- Product descriptionLomitapide
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001125
- Product descriptionBMS-201038 95.00%
- Packaging1MG
- Price$159.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10009610
- Product descriptionLomitapide ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10009610
- Product descriptionLomitapide ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10009610
- Product descriptionLomitapide ≥98%
- Packaging10mg
- Price$214
- Updated2024-03-01
- Buy
- ManufacturerChem-Impex
- Product number38015
- Product descriptionLomitapide,98%(HPLC) 98%(HPLC)
- Packaging25MG
- Price$184.8
- Updated2021-12-16
- Buy
- ManufacturerChem-Impex
- Product number38015
- Product descriptionLomitapide,98%(HPLC) 98%(HPLC)
- Packaging100MG
- Price$601.44
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002900
- Product descriptionLomitapide 98+%
- Packaging25mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002900
- Product descriptionLomitapide 98+%
- Packaging50mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002900
- Product descriptionLomitapide 98+%
- Packaging100mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002900
- Product descriptionLomitapide 98+%
- Packaging250mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7900
- Product descriptionAEGR-733(Lomitapide) >98%
- Packaging100mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7900
- Product descriptionAEGR-733(Lomitapide) >98%
- Packaging250mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7900
- Product descriptionAEGR-733(Lomitapide) >98%
- Packaging1g
- Price$1500
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Z1876 | Lomitapide | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | Z1876 | Lomitapide | 10mg | $336 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001125 | BMS-201038 95.00% | 1MG | $159.6 | 2021-12-16 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 100mg | $550 | 2021-12-16 | Buy |
| Cayman Chemical | 10009610 | Lomitapide ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10009610 | Lomitapide ≥98% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 10009610 | Lomitapide ≥98% | 10mg | $214 | 2024-03-01 | Buy |
| Chem-Impex | 38015 | Lomitapide,98%(HPLC) 98%(HPLC) | 25MG | $184.8 | 2021-12-16 | Buy |
| Chem-Impex | 38015 | Lomitapide,98%(HPLC) 98%(HPLC) | 100MG | $601.44 | 2021-12-16 | Buy |
| Crysdot | CD31002900 | Lomitapide 98+% | 25mg | $65 | 2021-12-16 | Buy |
| Crysdot | CD31002900 | Lomitapide 98+% | 50mg | $110 | 2021-12-16 | Buy |
| Crysdot | CD31002900 | Lomitapide 98+% | 100mg | $175 | 2021-12-16 | Buy |
| Crysdot | CD31002900 | Lomitapide 98+% | 250mg | $350 | 2021-12-16 | Buy |
| DC Chemicals | DC7900 | AEGR-733(Lomitapide) >98% | 100mg | $350 | 2021-12-16 | Buy |
| DC Chemicals | DC7900 | AEGR-733(Lomitapide) >98% | 250mg | $700 | 2021-12-16 | Buy |
| DC Chemicals | DC7900 | AEGR-733(Lomitapide) >98% | 1g | $1500 | 2021-12-16 | Buy |
Properties
Melting point :142°C(lit.)
Boiling point :778.2±60.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.66±0.20(Predicted)
form :powder
color :white to beige
Boiling point :778.2±60.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.66±0.20(Predicted)
form :powder
color :white to beige
Safety Information
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Description
Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC50 of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED50～0.2 mg/kg).Related product price
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