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ChemicalBook >> CAS DataBase List >> PD 0325901

PD 0325901

PD 0325901 price.
  • $8 - $1680
  • Product name: PD 0325901
  • CAS: 391210-10-9
  • MF: C16H14F3IN2O4
  • MW: 482.19
  • EINECS:687-152-7
  • MDL Number:MFCD08435926
  • Synonyms:N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;PD 0325901;(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide;PD-0235901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be;N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901;PD 0325901 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
50 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • Usbiological
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  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3711-M005
  • Product descriptionPD 0325901 ≥98%(HPLC)
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberW5947
  • Product description(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberW5947
  • Product description(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging1mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging5mg
  • Price$18
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging10mg
  • Price$26
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging25mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging250mg
  • Price$159
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA370482
  • Product description(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98%
  • Packaging1g
  • Price$401
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007709
  • Product descriptionPD 0325901 95.00%
  • Packaging1MG
  • Price$200.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007709
  • Product descriptionPD 0325901 95.00%
  • Packaging5MG
  • Price$523
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0007709
  • Product descriptionPD 0325901 95.00%
  • Packaging100MG
  • Price$1144.61
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3013
  • Product descriptionPD 0325901
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3013
  • Product descriptionPD 0325901
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60032
  • Product descriptionPD0325901(Mirdametinib)
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3711-M005 PD 0325901 ≥98%(HPLC) 5mg $45 2021-12-16 Buy
AK Scientific W5947 (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide 5mg $80 2021-12-16 Buy
AK Scientific W5947 (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide 10mg $135 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 1mg $8 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 5mg $18 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 10mg $26 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 25mg $44 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 100mg $98 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 250mg $159 2021-12-16 Buy
Ambeed A370482 (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide 98% 1g $401 2021-12-16 Buy
American Custom Chemicals Corporation API0007709 PD 0325901 95.00% 1MG $200.55 2021-12-16 Buy
American Custom Chemicals Corporation API0007709 PD 0325901 95.00% 5MG $523 2021-12-16 Buy
American Custom Chemicals Corporation API0007709 PD 0325901 95.00% 100MG $1144.61 2021-12-16 Buy
ApexBio Technology A3013 PD 0325901 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A3013 PD 0325901 25mg $150 2021-12-16 Buy
Arctom CFN60032 PD0325901(Mirdametinib) 10mg $218 2021-12-16 Buy

Properties

Melting point :112-114°C
Density :1.817±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :White to off-white solid
pka :13.45±0.20(Predicted)
color :white to off-white
optical activity :[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :SUDAHWBOROXANE-SECBINFHSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation with 1 μM PD 0325901 combined with 3 μM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.

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