PF-04691502
|
- $70 - $3728.1
- Product name: PF-04691502
- CAS: 1013101-36-4
- MF: C22H27N5O4
- MW: 425.48
- EINECS:
- MDL Number:MFCD18782794
- Synonyms:PF-04691502;2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-aMino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-Methoxypyridin-3-yl)-4-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;PF-04691502 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3;PF4691502;PF-04691502, 98%, a potent and selective inhibitor of PI3K and mTOR kinases;CS-2640
47 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5
- 10mg
- 25mg
- 25
- 2mg
- 5MG
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in1mLDMSO)
- 1000mg
- 10mM(in 1mL DMSO)
- 25 mg
- ManufacturerAK Scientific
- Product numberSYN5741
- Product descriptionPF-04691502
- Packaging100mg
- Price$1296
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000829
- Product descriptionPF-04691502 95.00%
- Packaging5MG
- Price$425.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging50mg
- Price$350
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging5mg
- Price$73
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging5mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging10mM(in 1mL DMSO)
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging10mg
- Price$109
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8499
- Product descriptionPF-04691502
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60072
- Product descriptionPF-04691502
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1855
- Product descriptionPF04691502 99%
- Packaging25mg
- Price$319
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1227154
- Product descriptionPF-04691502 >98%(HPLC)
- Packaging50mg
- Price$300
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1227154
- Product descriptionPF-04691502 >98%(HPLC)
- Packaging25mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1227154
- Product descriptionPF-04691502 >98%(HPLC)
- Packaging100mg
- Price$500
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1227154
- Product descriptionPF-04691502 >98%(HPLC)
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5741 | PF-04691502 | 100mg | $1296 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000829 | PF-04691502 95.00% | 5MG | $425.5 | 2021-12-16 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 50mg | $399 | 2021-12-16 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 50mg | $350 | 2026-05-06 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 5mg | $73 | 2026-05-06 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 5mg | $79 | 2021-12-16 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 10mM(in 1mL DMSO) | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 10mg | $109 | 2026-05-06 | Buy |
| ApexBio Technology | A8499 | PF-04691502 | 10mg | $119 | 2021-12-16 | Buy |
| Arctom | CFN60072 | PF-04691502 | 10mg | $288 | 2021-12-16 | Buy |
| Axon Medchem | Axon1855 | PF04691502 99% | 25mg | $319 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb1227154 | PF-04691502 >98%(HPLC) | 50mg | $300 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1227154 | PF-04691502 >98%(HPLC) | 25mg | $190 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1227154 | PF-04691502 >98%(HPLC) | 100mg | $500 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1227154 | PF-04691502 >98%(HPLC) | 5mg | $110 | 2026-05-06 | Buy |
Properties
Melting point :219-221°C
Boiling point :682.5±65.0 °C(Predicted)
Density :1.36
storage temp. :Refrigerator
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :14.39±0.10(Predicted)
color :Pale Yellow to Light Green
InChIKey :XDLYKKIQACFMJG-WKILWMFISA-N
SMILES :C1(N)=NC(C)=C2C=C(C3=CC=C(OC)N=C3)C(=O)N([C@@H]3CC[C@@H](OCCO)CC3)C2=N1
Boiling point :682.5±65.0 °C(Predicted)
Density :1.36
storage temp. :Refrigerator
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
form :Solid
pka :14.39±0.10(Predicted)
color :Pale Yellow to Light Green
InChIKey :XDLYKKIQACFMJG-WKILWMFISA-N
SMILES :C1(N)=NC(C)=C2C=C(C3=CC=C(OC)N=C3)C(=O)N([C@@H]3CC[C@@H](OCCO)CC3)C2=N1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
PF-04691502 is a potent, ATP competitive, dual inhibitor of PI3K and mTOR. It selectively inhibits human PI3K isoforms α, β, δ, and γ (Kis = 1.8, 2.1, 1.6, and 1.9 nM, respectively) and human mTOR (Ki = 16 nM) without significantly inhibiting a panel of more than 80 related protein kinases at concentrations up to 10 μM. PF-04691502 inhibits cell proliferation of BT20 (breast), SKOV3 (ovarian), and U87MG (glioblastoma) cancer cells with IC50 values of 313, 188, and 179 nM, respectively, and shows good in vivo efficacy in U87MG, SKOV3, and four separate non-small cell lung cancer xenograft mouse models. PF-04691502 has been used to inhibit activation of PI3K and mTOR effector kinases and prevent a p27-dependent increase in cell motility and invasion in a highly bone-metastatic model of breast cancer.Related product price
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