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Anti-tuberculous mycobacterium leprae drugs

In addition to Mycobacterium tuberculosis, other mycobacteria can also be pathogenic to humans. Because of their colonies formed during culture are not typical features of Mycobacterium tuberculosis, they are given the name "atypical mycobacteria", while now they are more commonly referred to as "non-tuberculous mycobacteria" (NTM).Mycobacterium tuberculosis can be divided into 4 groups according to the pigment production or rapid growth (Runyon, 1965). After the initial report published of Runyon's classification system, the report of disease caused by NTM lesions in the southeastern United States emerged. The epidemiology of these patients and general TB patients are different. These patients are older, most of whom are white, and their lungs are often suffered from chronic disease. However, the existing anti-TB drug treatment are ineffective. In order to understand the occurrence of NTM disease, we have found some information in the United States’ 1981-1983 epidemiological studies: the highest incidence is Mycobacterium avium complex (MAC), followed by Mycobacterium kansas and mycobacterium - Mycobacterium tumefaciens (O Brien et al., 1987). In some areas of the United States, NTM may be as common as tuberculosis. Human infections appear to arise from mycobacteria in the environment.
Leprosy is caused by leprosy bacillus infection. Mycobacterium leprae and Mycobacterium tuberculosis both belong to the genus Mycobacterium, and they have similar points in the form and response to drugs. Some anti-tuberculosis drugs can also be used for the treatment of leprosy, such as rifampicin which is the main leprosy drug, ammonia thiourea which also have a role. Anti-leprosy drugs are mainly sulfone drugs.

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Chemical Name	CAS	MF
4,4'-Diaminodiphenylsulfone	80-08-0	C12H12N2O2S
TMC-207	843663-66-1	C32H31BrN2O2
Isoniazid	54-85-3	C6H7N3O
Pyrazinamide	98-96-4	C5H5N3O
2-Mercaptobenzimidazole	583-39-1	C7H6N2S
4-Aminosalicylic acid	65-49-6	C7H7NO3
Ethionamide	536-33-4	C8H10N2S
Aluminoparaaminosalicylate calcium	14641-21-5	C14H13AlCaN2O8
Benzoylpas calcium pentahydrate	5631-00-5	C28H30CaN2O13
Phenyl-4-aminosalicylate	133-11-9	C13H11NO3
iproniazid	54-92-2	C9H13N3O
Steffimycin	11033-34-4	C28H30O13
Contezolid acefosamil	1807365-35-0	C20H19F3N4NaO8P
TERIZIDONE	25683-71-0	C14H14N4O4
Contezolid	1112968-42-9	C18H15F3N4O4
2(1H)-Quinolinone, 5-[[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxy-4-piperidinyl]methoxy]-8-fluoro-3,4-dihydro-	1883747-71-4	C21H20ClF3N2O4
Calcium 2-[[hydroxy(4-pyridyl)methylene]hydrazono]propionate	3428-05-5
1,4,7,10,13-Pentaazacyclohexadecane, cyclic peptide deriv.	53760-33-1	C50H92N26O32S3
Etocarlide	1234-30-6	C17H20N2O2S
Thalidomide	50-35-1	C13H10N2O4
Ethambutol dihydrochloride	1070-11-7	C10H24N2O2.2ClH
Ftivazide	149-17-7	C14H13N3O3
Pasiniazid	2066-89-9	C13H14N4O4
Protionamide	14222-60-7	C9H12N2S
isonoazone
Calcium 4-aminosalicylate	133-15-3	C7H9CaNO3
Ethambutol	74-55-5	C10H24N2O2
methaniazide	13447-95-5	C7H9N3O4S
Enviomycin	33103-22-9	C25H43N13O10
Isoniazid-D4	774596-24-6	C6H7N3O
1-PHENYL-1-PROPYNE	623-32-5	C20H36O2
LYSIONOTIN	152743-19-6	C18H16O7
2'-(sulphomethyl)isonicotinohydrazide, monosodium salt	3804-89-5	C7H9N3O4S.Na
morinamide	952-54-5	C10H14N4O2
SulfadiasulfoneSodium	128-12-1	C14H16N3NaO5S2
Sodium 4-aminosalicylate	133-10-8	C7H7NO3.Na
RIFAMPICIN	38776-75-9	C43H59N4NaO12
Clofazimine	2030-63-9	C27H22Cl2N4
Furilazone
solasulfone	133-65-3	C30H28N2O14S5.4Na
Aldesulfone Sodium	144-75-2	C14H14N2Na2O6S3
THIACETAZONE	104-06-3	C10H12N4OS
thiambutosine	500-89-0	C19H25N3OS
Rifamycin, 3-[[(4-methyl-1-piperazinyl)imino]methyl]-, mixt. with 4-pyridinecarboxylic acid hydrazide	51683-28-4	C49H65N7O13
Sodium 4-aminosalicylate dihydrate	6018-19-5	C7H10NNaO4
acediasulfone sodium	127-60-6	C14H15N2NaO4S
ISONICOTINIC ACID 2,2'-METHYLENEDIHYDRAZIDE	1707-15-9	C13H14N6O2