漆树酸
中文名称 | 漆树酸 |
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中文同义词 | 2-羟基-6-十五基苯甲酸;漆树酸;银杏酸C15:0 氢化漆树酸;氢化腰果酸;漆树酸/氢化白果酸;2-羟基-6-十五烷基苯甲酸;氢化白果酸(银杏酸C15:0) |
英文名称 | 6-pentadecylsalicylic acid |
英文同义词 | NSC 333857;NSC 623096;(15:0)-Anacardic acid;Ginkgolic Acid 15:0 〔Anacardic Acid 15:0〕;Hodrogenated anacardic acid;PENTADECYLSALICYLICACID;6-Pentadecyl-2-hydroxybenzoic acid;Cyclogallipharic acid |
CAS号 | 16611-84-0 |
分子式 | C22H36O3 |
分子量 | 348.52 |
EINECS号 | |
相关类别 | 二元酸;小分子抑制剂,天然产物;标准品;其它酚类;标准品 -中药标准品;通用生化试剂-有机酸;Inhibitors |
Mol文件 | 16611-84-0.mol |
结构式 |
漆树酸 性质
熔点 | 90-91℃ |
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沸点 | 474.8±33.0 °C(Predicted) |
密度 | 1.002 |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:≥20mg/mL |
形态 | 白色固体 |
酸度系数(pKa) | 3.08±0.30(Predicted) |
颜色 | 白色至米色 |
稳定性 | 自购买之日起,稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N |
LogP | 9.960 (est) |
Target | Value |
Tip60
(Cell-free assay) | |
PCAF
(Cell-free assay) | 5 μM |
p300/CBP
(Cell-free assay) | 8.5 μM |
Anacardic Acid is a histone acetyltransferase, inhibits HAT activity of p300 and PCAF, with IC 50 s of ∼8.5 μM and ∼5 μM, respectively. Anacardic Acid (300 μM) inhibits mycelial growth. Anacardic Acid (50 μM) induces apoptosis-like characteristics in M. oryzae , and the effect is caspase independent. Anacardic Acid (1-80 μM) leads to loss of mitochondrial potential. Anacardic Acid (1-60 μM) also exhibits antioxidant activity in M. oryzae .
Anacardic acid (5 mg/kg, i.p.) attenuates the binding of HATs to the promoter of MEF2A and reverse hyperacetylation of H3K9ac caused by phenylephrine in C57BL/6 mice. Anacardic acid inhibits the level of transcription on MEF2A and cardiac development-related downstream genes, attenuates the protein overexpression of cardiac downstream genes caused by phenylephrine, reverses and attenuates cardiac hypertrophy in the hearts of mice exposed to phenylephrine, and attenuates the left ventricular pressure and improves cardiac function in the cardiac hypertrophy mice.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | S7582 | 漆树酸 Anacardic Acid | 16611-84-0 | 10mg | 804.57元 |
2024/08/19 | S7582 | Anacardic Acid | 16611-84-0 | 10mM (1mL in DMSO) | 810.81元 |