坎利酮
中文名称 | 坎利酮 |
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中文同义词 | 雄甾-4,6-二烯-17β-醇-3-酮-17α-丙酸内酯;6-去氢睾(甾)酮-17α-丙酸-γ-内酯;烯睾丙内酯;卡利酮;螺内酯相关物质A;依普利酮CANRENONE杂质;坎利酮-D4;17α-(2-羧乙基)-17β-羟基雄甾-4,6-二烯-3-酮内酯 |
英文名称 | Canrenone |
英文同义词 | phanurane;pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph;sc9376;spirolactonesc14266;CANRENOIC ACID GAMMA LACTONE;CANRENONE;4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE;4,6-ANDROSTEN-17-ALPHA-YL-PROPIONIOACID-R-LACTONE |
CAS号 | 976-71-6 |
分子式 | C22H28O3 |
分子量 | 340.46 |
EINECS号 | 213-554-5 |
相关类别 | 医药原料药;小分子抑制剂;医药中间体;羰基化合物;心血管血液系统原料药;中间体刊利酮;Spironolacrone;Intermediates & Fine Chemicals;Pharmaceuticals;ASMANEX;甾体激素原料中间体;原料中间体-原料药;药物杂质及中间体;医药原料;其他类;杂质对照品;化学试剂;分析化学;Steroids |
Mol文件 | 976-71-6.mol |
结构式 |
坎利酮 性质
熔点 | 158-1600C |
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比旋光度 | D +24.5° (chloroform) |
沸点 | 416.25°C (rough estimate) |
密度 | 1.1236 (rough estimate) |
折射率 | 1.5000 (estimate) |
储存条件 | room temp |
溶解度 | 在DMSO中的溶解度为20mg/mL,澄清 |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D +17 to +24°, c = 1 in chloroform-d |
水溶解性 | 272.4ug/L(25 ºC) |
InChI | InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3 |
InChIKey | UJVLDDZCTMKXJK-MUWITHSMNA-N |
SMILES | [C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r| |
LogP | 2.54 at 25℃ |
CAS 数据库 | 976-71-6 |
NIST化学物质信息 | Canrenone(976-71-6) |
Human Endogenous Metabolite
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Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na + /H + exchanger 1 induced by platelet-derived growth factor.
Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
坎雷诺酮(螺内酯EP杂质F)是醛固酮拮抗剂。利尿剂。用于治疗心衰水肿和肝硬变腹水。