182073-77-4
| 中文名称 | 182073-77-4 |
|---|---|
| 中文同义词 | 化合物 T17288;化合物 ZD8321 |
| 英文名称 | N''-[N-Methoxycarbonyl-L-valyl]-N-[(S)-3,3,3-trifluor-1-isopropyl-2-oxopropyl]-L-prolinamide |
| 英文同义词 | L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-;ZD-8321,ZD8321;ZD8321;N''-[N-Methoxycarbonyl-L-valyl]-N-[(S)-3,3,3-trifluor-1-isopropyl-2-oxopropyl]-L-prolinamide |
| CAS号 | 182073-77-4 |
| 分子式 | C18H28F3N3O5 |
| 分子量 | 423.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 182073-77-4.mol |
| 结构式 |  |
182073-77-4 性质
| 沸点 | 573.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.22±0.46(Predicted) |
| 颜色 | 浅黄至黄色 |
ZD8321 是人 Neutrophil elastase (NE) 的有效抑制剂，其 Ki 值为 13±1.7 nM。
Ki: 13±1.7 nM (Neutrophil elastase)
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.