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| | 5-Bromo-2-hydroxymethylpyridine Basic information |
| | 5-Bromo-2-hydroxymethylpyridine Chemical Properties |
| Melting point | 59-60°C | | Boiling point | 0°C | | density | 1.668±0.06 g/cm3(Predicted) | | Fp | 0°C | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | 13.09±0.10(Predicted) | | color | White to Light yellow to Light orange | | InChI | InChI=1S/C6H6BrNO/c7-5-1-2-6(4-9)8-3-5/h1-3,9H,4H2 | | InChIKey | RUCZFWMEACWFER-UHFFFAOYSA-N | | SMILES | C1(CO)=NC=C(Br)C=C1 | | CAS DataBase Reference | 88139-91-7(CAS DataBase Reference) |
| | 5-Bromo-2-hydroxymethylpyridine Usage And Synthesis |
| Chemical Properties | Light yellow Cryst | | Uses | 5-Bromo-2-(hydroxymethyl)pyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | 5-bromo-2-pyridinecarboxylic acid, methyl ester (648mg, 3mmol) in 10ml of methanol was slowly added to sodium borohydride (340mg, 9mmol) in an ice bath. After that, the ice bath was removed and the reaction mixture was warmed to room temperature. The reaction was stirred for 12 hours. Then 1N HCl was added to adjust the pH to 1. Afterward, a saturated sodium bicarbonate solution was added to adjust the pH to 8. The mixture was then extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. This resulted in the formation of 535mg of white solid, which was identified as 5-bromo-2-pyridinemethanol. The yield of the desired product was 94.8%.
 | | References | [1] Journal of Inorganic Biochemistry, 2012, vol. 111, p. 1 - 9
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 6, p. 469 - 480
[3] Patent: US2013/12530, 2013, A1. Location in patent: Paragraph 0178
[4] Patent: WO2008/32191, 2008, A2. Location in patent: Page/Page column 58
[5] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 228 |
| | 5-Bromo-2-hydroxymethylpyridine Preparation Products And Raw materials |
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