BOC-D-焦谷氨酸甲酯 基本信息
| 中文名称 | BOC-D-焦谷氨酸甲酯 |
|---|---|
| 中文同义词 | N-叔丁氧羰基-L-焦谷氨酸甲酯;BOC-D-焦谷氨酸甲酯;(R)-N-BOC-5-甲氧羰基-2 - 吡咯烷酮;(R)-1-叔丁基2-甲基5-氧代吡咯烷-1,2-二羧酸酯;1-BOC-5-氧代-D -脯氨酸甲酯;BOC-D-焦谷氨酸甲酯 N-叔丁氧羰基-L-焦谷氨酸甲酯 R-N-BOC-焦谷氨酸甲酯 N-叔丁氧羰基-D-焦谷氨酸甲酯 (R)-N-BOC-5-甲氧羰基-2 - 吡咯烷酮;N-BOC-D-焦谷氨酸甲酯;R-N-BOC-焦谷氨酸甲酯 |
| 英文名称 | (R)-N-Boc-5-methoxycarbonyl-2-pyrrolidinone |
| 英文同义词 | (R)-5-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER;Boc-D-Pyroglutamic acid methyl ester;Boc-L-pyroglutamic acid methyl ester;(R)-1-Tert-butyl2-Methyl5-oxopyrrolidine-1,2-dicarboxylate;(R)-N-(tert-butoxycarbonyl)pyroglutaMate;1-Boc-5-oxo-D-proline Methyl ester;(2R)-5-oxo-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester;utamic Acid MethyL |
| CAS号 | 128811-48-3 |
| 分子式 | C11H17NO5 |
| 分子量 | 243.26 |
| EINECS号 | |
| 相关类别 | 氨基酸及其衍生物;氨基酸及衍生物;医药中间体;医药中间体、氨基酸衍生物;氨基酸;化工中间体 |
| Mol文件 | 128811-48-3.mol |
| 结构式 |  |
BOC-D-焦谷氨酸甲酯 性质
| 熔点 | 68-69℃ |
|---|---|
| 沸点 | 361.6±35.0 °C(Predicted) |
| 密度 | 1.209 |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 酸度系数(pKa) | -4.28±0.40(Predicted) |
| 外观 | 白色至灰白色固体 |
| InChI | InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m1/s1 |
| InChIKey | FNTAOUUEQHKLIU-SSDOTTSWSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C(=O)CC[C@@H]1C(OC)=O |
24424-99-5
68766-96-1
144978-12-1
以二碳酸二叔丁酯和D-焦谷氨酸乙酯为原料合成BOC-L-焦谷氨酸乙酯的一般步骤：将D-焦谷氨酸乙酯（5.1g，32.6mmol）溶于二氯甲烷（70ml）中，依次加入三乙胺（4.55ml，32.6mmol）、二碳酸二叔丁酯（14.2g，65.2mmol）和4-（二甲基氨基）吡啶（3.98g，32.6mmol）。将反应混合物在室温下搅拌1.5小时，通过薄层色谱（TLC）监测反应进程，确认反应完全。反应完成后，将反应液用水洗涤两次，再用盐水洗涤，有机相用无水硫酸钠干燥，过滤后减压浓缩。粗产物通过柱色谱法（洗脱剂比例为1:1的乙酸乙酯/石油醚）纯化，得到Boc-D-焦谷氨酸乙酯，为浅黄色粘稠油状物（7.98g，收率95%），静置后固化为固体。
参考文献：
[1] Patent: WO2007/36730, 2007, A1. Location in patent: Page/Page column 120
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1383 - 1393
[3] Patent: EP1847536, 2007, A1. Location in patent: Page/Page column 28
[4] Patent: US2009/48213, 2009, A1. Location in patent: Page/Page column 70-71
[5] Patent: US2011/34469, 2011, A1. Location in patent: Page/Page column 124
安全信息
| 海关编码 | 2933790090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | XW1288114833 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 5G | 46元 |
| 2025/05/22 | XW1288114832 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 1G | 32元 |