ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >(S)-(+)-3-Hydroxytetrahydrofuran


(S)-(+)-3-Hydroxytetrahydrofuran Suppliers list
Company Name: Suzhou Ryan Pharmachem Technology Co.,Ltd.
Tel: +86-512-68780025 +8618962125825
Products Intro: Product Name:(S)-(+)-3-Hydroxytetrahydrofuran
Purity:98% Package:10KG;0.00;USD|50KG;0.00;USD|100KG;0.00;USD Remarks:RA-40025
Company Name: Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel: 027-88013699 17354350817
Products Intro: Product Name:(S)-(+)-3-Hydroxytetrahydrofuran
Purity:0.99 Package:25kg,50kg,180kg,200kg,250kg,1000kg,as your needs Remarks:as your needs
Company Name: Porton Pharma Solutions Ltd.
Products Intro: Product Name:(S)-3-hydroxytetyrahydrofuran
Purity:To be communicated Package:To be communicated
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Products Intro: Product Name:(S)-(+)-3-Hydroxytetrahydrofuran
Purity:99% Package:25KG
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Products Intro: Product Name:(S)-(+)-3-Hydroxytetrahydrofuran
Purity:0.99 Package:1kg Remarks:Factory direct sales

(S)-(+)-3-Hydroxytetrahydrofuran manufacturers

Related articles

(S)-(+)-3-Hydroxytetrahydrofuran Basic information
Product Name:(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms:(S)-(+)-TETRAHYDRO-3-FURANOL;(S)-(+)-3-HYDROXY TETAHYDRO FURAN;(2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol;Afatinib intermediate B;(S)-(+)-3-Hydroxytetrahydrofuran, ee: 95%;Afatinib intermediate;(S)-(+)-3-HydroxytetrahydrofuranZ;(S)-(+)-3-Hydroxytetrahydrofuran 99%
Product Categories:Afatinib intermediate;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Chiral Reagents;Furans;Starting Raw Materials & Intermediates;Small molecule;Tetrahydrofuran Series;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;bc0001;86087-23-2;john's;ADVANCED INT.
Mol File:86087-23-2.mol
(S)-(+)-3-Hydroxytetrahydrofuran Structure
(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties
alpha 18.5 º (c=2 MeOH)
Boiling point 80 °C/15 mmHg (lit.)
density 1.103 g/mL at 25 °C (lit.)
vapor pressure 47Pa at 25℃
refractive index n20/D 1.45(lit.)
Fp 175 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
form Liquid
color Clear colorless to pale yellow
Specific Gravity1.11
optical activity[α]20/D +17.5°, c = 2.4 in methanol
Water Solubility soluble
BRN 4652609
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
LogP-0.784 at 22℃ and pH6.8
Surface tension72mN/m at 1g/L and 25℃
CAS DataBase Reference86087-23-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
HS Code 29321900
MSDS Information
ACROS English
SigmaAldrich English
(S)-(+)-3-Hydroxytetrahydrofuran Usage And Synthesis
Description(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88?89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C).[3] 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
Chemical PropertiesColourless Liquid
Uses(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
Uses(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
Synthesis(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows:To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.S)-(+)-3-Hydroxytetrahydrofuran synthesis
Tag:(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2) Related Product Information
Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one (R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL