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| | Alizapride Basic information |
| Product Name: | Alizapride | | Synonyms: | ALIZAPRIDE;n-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide;1h-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met;6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo;Nausilen;Plitican;Vergentan;6-Methoxy-N-{[1-(2-propnyl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide | | CAS: | 59338-93-1 | | MF: | C16H21N5O2 | | MW: | 315.37 | | EINECS: | 261-710-6 | | Product Categories: | | | Mol File: | 59338-93-1.mol |  |
| | Alizapride Chemical Properties |
| Melting point | 139° | | Boiling point | 580.3±40.0 °C(Predicted) | | density | 1.224±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 7.09±0.40(Predicted) | | CAS DataBase Reference | 59338-93-1(CAS DataBase Reference) |
| Toxicity | LD50 i.v. in mice (5 days): 92.7 mg/kg (Bulteau) |
| | Alizapride Usage And Synthesis |
| Originator | Plitican ,Delagrange ,France ,1981 | | Definition | ChEBI: 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide is a member of benzotriazoles. | | Manufacturing Process | 38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in
anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine
were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of
phosphoric anhydride were added. The mixture was warmed at reflux
temperature for 3 hours and then cooled to 80°C. After adding water, the
aqueous layer was alkalized. The crystals were filtered, washed with water
and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5-
azimidobenzamide having a melting point of 139°C were obtained. | | Therapeutic Function | Neuroleptic, Antiemetic |
| | Alizapride Preparation Products And Raw materials |
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