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Isoamyl nitrite

Isoamyl nitrite Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Isoamyl nitrite
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:110-46-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Products Intro: Product Name:Isoamyl nitrite
Purity:as in COA Package:as customers' requirements
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name: Isoamyl nitrite
CAS: 110-46-3
Purity:99% Package:1KG;11USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Products Intro: Product Name:Isoamyl Nitrite
Purity:99% Package:5KG;1KG

Lastest Price from Isoamyl nitrite manufacturers

  • Isoamylnitrite
  • US $100.00 / KG
  • 2020-07-21
  • CAS:110-46-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 40 Ton/Tons per Month
  • Isoamyl nitrite
  • US $0.00-0.00 / KG
  • 2020-05-12
  • CAS:110-46-3
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 500 MT
  • Isoamyl nitrite
  • US $11.00 / KG
  • 2019-07-06
  • CAS: 110-46-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
Isoamyl nitrite Basic information
Antianginal drugs Cyanide poisoning antidote Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Explosive hazardous characteristics Flammability hazard characteristics Storage characteristics Extinguishing agent
Product Name:Isoamyl nitrite
Synonyms:Isoamyl nitrite,97%,stabilized;IsoaMyl nitrite, stabilized, 90% 100GR;IsoaMyl nitrite, 96%, stabilized;ISOPENTYL NITRITE EXTRA PURE STABILIZED;Nitrite isoaMyl acetate (110-46-3) - 2;sopentyl nitrite;Isoamyl nitrite 3-Methylbutyl Nitrite;Isopentyl nitrite, stabilized with 0.2% anhyd. sodium carbonate
Product Categories:Organics
Mol File:110-46-3.mol
Isoamyl nitrite Structure
Isoamyl nitrite Chemical Properties
Boiling point 99 °C(lit.)
density 0.872 g/mL at 25 °C(lit.)
refractive index n20/D 1.386(lit.)
Fp 50 °F
storage temp. 2-8°C
form Liquid
color Clear yellow
Water Solubility <0.01 g/100 mL at 18 ºC
Sensitive Air & Light Sensitive
Merck 14,5123
BRN 969510
Stability:Stability Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents.
CAS DataBase Reference110-46-3(CAS DataBase Reference)
NIST Chemistry ReferenceAmyl Nitrite(110-46-3)
EPA Substance Registry SystemIsoamyl nitrite (110-46-3)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/22
Safety Statements 16-24-46
RIDADR UN 1113 3/PG 2
WGK Germany 1
RTECS NT0187500
Autoignition Temperature208 °C
HazardClass 3
PackingGroup II
HS Code 29209090
Hazardous Substances Data110-46-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 505 mg/kg
MSDS Information
SigmaAldrich English
ACROS English
ALFA English
Isoamyl nitrite Usage And Synthesis
Antianginal drugsLight yellow transparent liquid, ether-like smell with fruity. It volatiles at room temperature, and is easy to burn. It is insoluble in water, can be mixed with alcohol, ether, chloroform or benzene arbitrary at any ratio. In case of light and air it will break down.
Isoamyl nitrite, also known as amyl nitrite, is the fastest onset, and the shortest duration of anti-anginal drugs, is a sub-short-acting nitrates vasodilator, its pharmacological effects is similar to nitroglycerin, it can directly relax vascular smooth muscle, especially for small vascular smooth muscle, make systemic vasodilation, reduce peripheral resistance, blood pressure, reduce venous return blood, reduce cardiac output, thereby reduce myocardial oxygen consumption, anti-angina and effectively stimulate sexual desire. Because of its rapid hydrolysis in the gastrointestinal tract, so this product is oral invalid, drugs used clinically are usually made on a volatile liquid pharmaceutical inhalants, rapidly absorbed in the lungs after inhalation, it can be effective less than half a minute , lasts for only 3 to 10 minutes, the anti-anginal effect nitroglycerin similar, but inhaled dose of this product is difficult to control, and the adverse reaction is large, which is its shortcomings. Because it often causes severe headache, severe hypotension and tachycardia, it is now rarely used in clinical treatment of angina and biliary colic, gradually being replaced by other nitrates.
[Adverse reactions and Precautions]
Common adverse reactions are headache, facial flushing, hypotension and reflex tachycardia ect. Isoamyl nitrite owns severe reaction than nitroglycerin.
Excessive use dosage can cause low blood pressure and heart rate, increase symptoms of angina, heart rate and blood pressure should be closely observed during intravenous drug using. Due to excessive methemoglobin poisoning, symptoms include cyanosis, breathing difficulty and other symptoms of hypoxia, intravenous injection of 1% methylene blue is used for first aid, along with oxygen , and blood transfusions.
Usinge for head trauma, brain hemorrhage, acute coronary thrombosis is banned.
Using in coronary occlusion and increased intracranial pressure is banned.
Cyanide poisoning antidotePharmacological effects are the same with sodium nitrite, isoamyl nitrite is also an oxidizing agent, hemoglobin is oxidized to be high iron (Fe3 +) hemoglobin combines with cyanide ions to form cyanide methemoglobin, eliminates blood free cyanide ions on cytochrome oxidase enzyme infringement, but also makes the cytochrome oxidase bound cyanide ion release, leading to the enzyme activity and tissue respiration function recovery, it should be used simultaneously with sodium thiosulfate to bind with cyanide methemoglobin to form non-toxic thiocyanate group (SCN-) and excreted, and thus play a role in the treatment of cyanide poisoning. This product is administrated by inhalation, rapidly absorbed in the lungs, displays the effects after inhalation of 10 to 30 seconds, the role lasts for 3 to 5 minutes. For emergency use, sodium nitrite is intravenous injected until the symptoms improve.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical PropertiesLight yellow clear liquid having a boiling point of 99 °C, the relative density is 0.871 (20/4 ℃), the refractive index is 1.3871, the flash point is 10 ℃. It is soluble with alcohol, ether, it can not dissolve in water. With fruit flavor. With volatility, it will break down in the case of light and air .
UsesIt is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent. Isobutyl nitrite ester is a drug that is the the fastest short-acting nitrates vasodilator. It is also used as hydrocyanic acid and its salts poisoning antidote.Vasodilators, for the treatment of angina pectoris, also it is used for cyanide poisoning; it is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent.
Production methodIt is derived from isoamyl alcohol and sodium nitrite. According to the actual production situation, it may have a different method of operation. 1. The reaction takes place in the reaction tube, in synthetic aqueous solution of sodium nitrite, isoamyl alcohol, hydrochloric acid, respectively, are put into the high slot. First sodium nitrite solution and hydrochloric acid solution are dropped at the same rate into the synthesis pipe, when the chlorine gas bubbles in the pipe,isoamyl alcohol is slowly dropped from the top of the pipe, that is in the pipeline synthetic crude. Washed, dried, fractionated to get the products. 2. The reaction is carried out in a reaction tank of sodium nitrite, isoamyl alcohol and water are added to the reaction pot, stirring, cooling to 5 ℃, solution of hydrochloric acid is dropped. At 5 ℃ insulation for 1h, after standing hours to remove the water layer, acetate layer is washed with water, then washed with sodium carbonate solution, and then washed with water. After removing the layer of water, it is dehydrated with anhydrous sodium carbonate, filtered. The filtrate is distilled, collecting 97-99 ℃ distillate, to get isoamyl nitrite.
CategoryFlammable liquid
Toxicity gradingHighly toxic
Acute toxicityOral-rat LD50: 505 mg/kg; inhalation-mouse LC50: 1430 PPM/30 min
Explosive hazardous characteristicsHeating can be explosive
Flammability hazard characteristicsIn the case of fire, high temperature, oxidant, it is flammable; in the case of light, heat may generate toxic nitric oxide gas.
Storage characteristicsTreasury should be ventilation, low-temperature and dry; It should be stored separately from oxidants and acids.
Extinguishing agentDry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Propertiesyellow liquid
Chemical PropertiesAmyl nitrites are flammable, yellowish liquid with a penetrating, fruity odor.
Chemical PropertiesIsoamyl Nitrite is flammable and explosive and decomposes when exposed to air and sunlight.
UsesIsoamyl nitrite is a light yellow, transparent liquid with a pleasant, fragrant, fruity odor. Amyl nitrite was introduced to medicine in 1859 and has been under considerable pharmacological investigation since that time. Its major use was for treating angina pectoris through its vasodilative effect on the coronary arteries. However, this effect is transient, and nitroglycerin and longer acting nitrates have largely replaced it. Amyl nitrite has been most helpful in clarifying the differential diagnosis of murmurs. For example, left ventricular outflowobstruction increases followingamyl nitrite administration. Mitral regurgitation decreases following amyl nitrite as does the apical diastolic rumble of mitral stenosis. The Austin–Flint rumble decreases followingamyl nitrite as does a ventricular septal defect and acyanotic tetralogy of Fallot. Pulmonic stenosis increases as does isolated valvular pulmonary stenosis following amyl nitrite.
Isoamyl nitrite has also been reportedly used for inhalation abuse. The symptoms following inhalation of large doses by humans are flushing of the face, pulsatile headache, disturbing tachycardia, cyanosis (methemoglobinemia), weakness, confusion, restlessness, faintness, and collapse, particularly if the individual is standing. The symptoms are usually of short duration. Industrial intoxication has not been reported.
DefinitionChEBI: A nitrite ester having isopentyl as the alkyl group.
General DescriptionClear yellow liquid.
Air & Water ReactionsHighly flammable. Decomposes on exposure to air and light. Insoluble in water.
Reactivity ProfileIsoamyl nitrite is an oxidizing agent but can serve as a reducing agent. Forms explosive mixtures with air or oxygen. .
HazardFlammable, dangerous fire risk, a strong oxidizer. Vapor may explode if ignited.
Fire HazardIsoamyl nitrite is flammable.
Potential ExposureAmyl nitrite is used to make pharmaceuticals; perfumes, diazonium compounds, and other chemicals.
ShippingUN1993 Flammable liquids, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name Required.
IncompatibilitiesVapors may form explosive mixture with air. Slowly decomposes in light, heat, and on contact with water. A strong oxidizer. Contact with reducing agents and easily oxidizable materials may cause fire and explosions. Reported to be an explosion hazard when exposed to air and light. Keep away from alcohols, antipyrine, alkaline materials; alkaline carbonates; potassium iodide; bromides, and ferrous salts. Attacks metals in the presence of moisture.
Waste DisposalIncineration with scrubber to remove nitrogen oxides from the combustion gases.
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