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N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE

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N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SecinH3
CAS:853625-60-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:SecinH3
CAS:853625-60-2
Purity:98% Package:5mg Remarks:V11179
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:SecinH3
CAS:853625-60-2
Package:10 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:Secin H3
CAS:853625-60-2
Purity:97% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SecinH3
CAS:853625-60-2
Purity:98% Package:$150.9/5mg;$231.9/10mg;$972.9/50mg;$1751.9/100mg;Bulk package Remarks:98%
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Basic information
Product Name:N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
Synonyms:N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE;SECINH3;N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide;3]dioxol-5-yl)-3-methoxy-1H-1;4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide;N-(4-(5-(benzo[d][1;CS-2379;Acetamide, N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-
CAS:853625-60-2
MF:C24H20N4O4S
MW:460.51
EINECS:
Product Categories:Inhibitors
Mol File:853625-60-2.mol
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Structure
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Chemical Properties
storage temp. Inert atmosphere,2-8°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.3 mg/ml
form White powder solid.
Safety Information
MSDS Information
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Usage And Synthesis
UsesSecinH3 is a Sec7 cytohesin inhibitor.
DefinitionChEBI: N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide is a member of triazoles.
General DescriptionA cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 ≤5.6 μM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 ≥65 μM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.
Biological ActivitySec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC 50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μ M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
Biochem/physiol ActionsPrimary TargetCytohesin
storageStore at +4°C
N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Preparation Products And Raw materials
Tag:N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE(853625-60-2) Related Product Information
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