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Troxerutin

Troxerutin Suppliers list
Company Name: Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Tel: +86-029-86185165 +8618629664246
Email: guoyuan@eastchinapharm.com
Products Intro: Product Name:Troxerutin
CAS:7085-55-4
Company Name: Chengdu ChenLv Herb Co.,Ltd
Tel: +undefined13608205856
Email: maryextract@126.com
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CAS:7085-55-4
Purity:EP10.0 Package:25kg;|15kg;|5kg
Company Name: Wuhan Boyuan Import & Export Co., LTD
Tel: +86-15175982296 15175982296;
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Products Intro: Product Name:Troxerutin
CAS:7085-55-4
Purity:99% Package:1kg;6USD
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Email: peter@yan-xi.com
Products Intro: Product Name:Troxerutin
CAS:7085-55-4
Purity:0.99 Package:1kg Remarks:Factory direct sales
Company Name: Shaanxi Haibo Biotechnology Co., Ltd
Tel: +86-02963020060 +86-18629295024
Email: hibo06@xaltbio.com
Products Intro: Product Name:Troxerutin
CAS:7085-55-4
Purity:99% Package:25kg Remarks:White Powder

Troxerutin manufacturers

  • Troxerutin
  • Troxerutin pictures
  • $10.00 / 1kg
  • 2024-02-22
  • CAS:7085-55-4
  • Min. Order: 1kg
  • Purity: DAB1999,EP9
  • Supply Ability: 10000
  • Troxerutin
  • Troxerutin pictures
  • $6.00 / 1kg
  • 2024-01-08
  • CAS:7085-55-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 5000ton
  • TROXERUTIN
  • TROXERUTIN pictures
  • $0.00 / 1kg
  • 2023-11-18
  • CAS:7085-55-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 500000kg
Troxerutin Basic information
Product Name:Troxerutin
Synonyms:3μ,4μ,7-Tris[O-(2-hydroxyethyl)]rutin, Troxerutin;Troxerutin,Trihydroxyethylrutin;3',4',7-Tris(hydroxyethyl)rutin;3,5-Dihydroxy-3',4',7-tris(2-hydroxyethoxy)flavone 3-rutinoside;Factor-P-zyma;2-[3,4-BIS(2-HYDROXYETHOXY)PHENYL]-3-[[6-O-(6-O-DEOXY-A-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-5-HYDROXY-7-(2-HYDROXYETHOXY)-4H-1-BENZOPYRAN-4-ONE;Trihydroxylrutin;Trihydroxyethylrutoside
CAS:7085-55-4
MF:C33H42O19
MW:742.68
EINECS:230-389-4
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Natural Plant Extract;Miscellaneous Natural Products;Inhibitors;Plant extracts;Herb extract;POSORUTIN;Aromatics;Heterocycles;Oligosaccharides;TROXEPURE;7085-55-4
Mol File:7085-55-4.mol
Troxerutin Structure
Troxerutin Chemical Properties
Melting point 181°C
Boiling point 1058.4±65.0 °C(Predicted)
density 1.65±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
pka5.92±0.40(Predicted)
color Light Yellow to Yellow
Merck 14,9789
BRN 4778232
InChIKeyKMPBUGGPUQOWMJ-NXPSPVSKSA-N
CAS DataBase Reference7085-55-4(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS LK8331500
HS Code 2938100000
MSDS Information
ProviderLanguage
3',4',7-Tris[O-(2-hydroxyethyl)]rutin English
Troxerutin Usage And Synthesis
Chemical PropertiesYellow Powder
OriginatorVenoruton,Novartis Co
Usesvasoprotectant
UsesUsed in the treatment of venous disorders
UsesTroxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.
Manufacturing ProcessIn a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland
Therapeutic FunctionTopical venotonic
targetVEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt
Troxerutin Preparation Products And Raw materials
Raw materials2-Chloroethanol-->Sodium hydroxide-->Rutin
Tag:Troxerutin(7085-55-4) Related Product Information
Nicotinic acid Retinyl acetate LITHIUM CITRATE TETRAHYDRATE Vitamin D3 VITAMIN CK3 Thiamine hydrochloride Troxerutin 2-(2-Aminoethylamino)ethanol Tricine Hydroxyethyl Cellulose Hydroxyethyl starch 2-(METHYLSULFONYL)ETHANOL TRIS BUFFER SOLUTION PH 8.5, 1 L 2-Hydroxyethanesulphonic acid TROXERUTIN=65% Rutin Sodium isethionate BUFFER SOLUTION PH = 6,00 (20 °C) (POTASSIUM DIHYDROGEN PHOSPHATE/SODIUM HYDROXIDE)