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| | Dimethyl 1,4-cyclohexanedicarboxylate Basic information |
| Product Name: | Dimethyl 1,4-cyclohexanedicarboxylate | | Synonyms: | 1,4-DIMETHYL CYCLOHEXANEDICARBOXYLATE;1,4-CYCLOHEXANEDICARBOXYLIC ACID DIMETHYL ESTER;HEXAHYDROTEREPHTHALIC ACID DIMETHYL ESTER;CYCLOHEXANE-1,4-DICARBOXYLIC ACID DIMETHYL ESTER;DIMETHYL 1,4-CYCLOHEXANEDICARBOXYLATE;1,4-Cyclohexanedicarboxylic acid dimethyl ester,c&t;DiMethyl 1,4-cyclohexanedicarboxylate, Mixture of cis and trans, 90-95% 25GR;1,4-Cyclohexanedicarboxylic acid, 1,4-diMethyl ester | | CAS: | 94-60-0 | | MF: | C10H16O4 | | MW: | 200.23 | | EINECS: | 202-347-5 | | Product Categories: | 4-Substituted Cyclohexanecarboxylic Acids;C10 to C11;Carbonyl Compounds;Esters;Organic Building Blocks;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis | | Mol File: | 94-60-0.mol |  |
| | Dimethyl 1,4-cyclohexanedicarboxylate Chemical Properties |
| | Dimethyl 1,4-cyclohexanedicarboxylate Usage And Synthesis |
| Chemical Properties | clear colorless liquid after melting | | Uses | Dimethyl cyclohexane-1,4-dicarboxylate, mixture of cis and trans may be used in chemical synthesis studies. | | Uses | 1,4-Cyclohexanedicarboxylic Dimethyl Ester is a building block that has been used as a reactant for the preparation of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase. | | Flammability and Explosibility | Non flammable | | Synthesis | Methanol (500 mL) was cooled to 0°C under ice-salt bath conditions and thionyl chloride (138 g, 4.0 eq.) was added slowly and dropwise. Cis-1,4-cyclohexanedicarboxylic acid (50 g, 1.0 eq.) was added to the above prepared HCl-methanol solution, followed by heating and refluxing the reaction mixture for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by evaporation and the residue was diluted with distilled water and extracted with ethyl acetate (3 x 100 mL). The combined ethyl acetate layers were washed sequentially with saturated NaHCO3 solution and saturated brine and dried over anhydrous Na2SO4. Finally, the solvent was removed by evaporation to give dimethyl 1,4-cyclohexanedicarboxylate (56.4 g, 97% yield) as a white solid. | | References | [1] Patent: WO2012/154204, 2012, A1. Location in patent: Page/Page column 83; 84
[2] Journal of Physical Chemistry A, 2010, vol. 114, # 3, p. 1446 - 1456
[3] Patent: WO2012/145569, 2012, A1. Location in patent: Page/Page column 134 |
| | Dimethyl 1,4-cyclohexanedicarboxylate Preparation Products And Raw materials |
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